维生素D与病毒感染之间的相互作用

StephenW

The interplay between vitamin D and viral infections; Teymoori-Rad M, Shokri F, Salimi V, Marashi S; Reviews in Medical Virology e2032 (Jan 2019)

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        Viral Infections

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The pleiotropic role of vitamin D has been explored over the past decades and there is compelling evidence for an epidemiological association between poor vitamin D status and a variety of diseases. While the potential anti-viral effect of vitamin D has recently been described, the underlying mechanisms by which vitamin D deficiency could contribute to viral disease development remain poorly understood. The possible interactions between viral infections and vitamin D appear to be more complex than previously thought. Recent findings indicate a complex interplay between viral infections and vitamin D, including the induction of anti-viral state, functional immunoregulatory features, interaction with cellular and viral factors, induction of autophagy and apoptosis, and genetic and epigenetic alterations. While crosstalk between vitamin D and intracellular signalling pathways may provide an essential modulatory effect on viral gene transcription, the immunomodulatory effect of vitamin D on viral infections appears to be transient. The interplay between viral infections and vitamin D remains an intriguing concept, and the global imprint that vitamin D can have on the immune signature in the context of viral infections is an area of growing interest.

StephenW

维生素D与病毒感染之间的相互作用; Teymoori-Rad M，Shokri F，Salimi V，Marashi S;医学病毒学e2032（2019年1月）的评论

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        病毒感染

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在过去的几十年中，人们一直在研究维生素D的多效作用，并且有令人信服的证据表明维生素D状况不佳与各种疾病之间存在流行病学关联。尽管最近已经描述了维生素D的潜在抗病毒作用，但维生素D缺乏可能导致病毒性疾病发展的潜在机制仍然知之甚少。病毒感染和维生素D之间可能的相互作用似乎比以前认为的更复杂。最近的研究结果表明病毒感染和维生素D之间存在复杂的相互作用，包括诱导抗病毒状态，功能性免疫调节特征，与细胞和病毒因子的相互作用，诱导自噬和细胞凋亡，以及遗传和表观遗传改变。虽然维生素D和细胞内信号通路之间的串扰可能对病毒基因转录提供必要的调节作用，但维生素D对病毒感染的免疫调节作用似乎是短暂的。病毒感染和维生素D之间的相互作用仍然是一个有趣的概念，维生素D在病毒感染背景下对免疫特征的全球印记是一个越来越受关注的领域。