人类白细胞抗原系统可能在HBV感染过程中发挥作用

StephenW

Virginia Schad, PharmD
January 14, 2019
Human Leukocyte Antigen System Likely Plays a Role in Course of HBV Infections
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No association of the 3 single nucleotide polymorphisms with the stages of chronic HBV infection was found. No association of the 3 single nucleotide polymorphisms with the stages of chronic HBV infection was found.

The human leukocyte antigen (HLA) system likely plays a role in the course of hepatitis B virus (HBV) infections, as the rs3077-T allele has been found to be associated with persistent HBV infection in Caucasians, according to the results of a retrospective case-control study published in Liver International.1

In patients with HBV, the occurrence of long-term complications becomes more frequent over time, especially in patients in the hepatitis phase compared with patients in the HBe antigen (Ag)-negative chronic infection phase and lowest in patients achieving seroclearance of HBsAg with or without the development of anti-HBs antibodies.2,3 HLA single nucleotide polymorphisms (SNPs) were found to be associated with spontaneous HBsAg loss in Asian populations.4-14

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A few studies with ambiguous findings have assessed the influence of HLA-DP polymorphisms on the course of HBV infection in Caucasians.15-18 Therefore, researchers investigated the impact of the rs3077, rs9277535, and rs9277534 single nucleotide polymorphisms (SNPs) on the clinical outcome of HBV infection in 1111 Caucasians, including 618 with chronic HBV infection, 239 with spontaneous HBsAg seroclearance, and 254 healthy controls.1

The researchers found that there was a significant difference in the allele distributions for rs3077 SNP between healthy controls and patients with chronic HBV infection, as well as between patients with seroclearance and patients with chronic HBV infection.  While the rs3077-C allele was associated with a lower probability for spontaneous HBsAg seroclearance compared with the rs3077-T allele (P =.033), no association of the 3 SNPs with the stages of chronic HBV infection was found.

“In conclusion, our results demonstrate for the first time the association of rs3077 with persistent HBV infection in a Caucasian population” stated the investigators.1 They added that, “Further studies are needed to elucidate the role of HLA-DP variants in disease pathogenesis and their potential role for individualized disease management.”

StephenW

Virginia Schad，PharmD
2019年1月14日
人类白细胞抗原系统可能在HBV感染过程中发挥作用
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没有发现3种单核苷酸多态性与慢性HBV感染阶段的关联。没有发现3种单核苷酸多态性与慢性HBV感染阶段的关联。

根据回顾的结果，人类白细胞抗原（HLA）系统可能在乙型肝炎病毒（HBV）感染过程中发挥作用，因为已经发现rs3077-T等位基因与高加索人的持续性HBV感染有关。病例对照研究发表于肝脏国际

在HBV患者中，长期并发症的发生随着时间的推移变得更加频繁，特别是在肝炎阶段的患者与HBe抗原（Ag）阴性慢性感染阶段的患者相比，并且在患有HBsAg血清清除的患者中最低。没有抗HBs抗体的发展.2,3 HLA单核苷酸多态性（SNPs）与亚洲人群自发性HBsAg消失有关.4-14

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一些含糊不清的研究评估了HLA-DP多态性对高加索人HBV感染过程的影响.15-18因此，研究人员调查了rs3077，rs9277535和rs9277534单核苷酸多态性（SNPs）对临床的影响。 1111例白种人HBV感染结果，包括618例慢性HBV感染，239例自发性HBsAg血清清除，254例健康对照。

研究人员发现，健康对照组和慢性HBV感染患者之间，以及血清清除患者和慢性HBV感染患者之间rs3077 SNP的等位基因分布存在显着差异。虽然与rs3077-T等位基因相比，rs3077-C等位基因与自发性HBsAg血清清除的可能性较低相关（P = .033），但未发现3个SNP与慢性HBV感染阶段的关联。

“总之，我们的结果首次证明了rs3077与高加索人群中持续性HBV感染的关联”研究者们表示。他们补充说：“需要进一步的研究来阐明HLA-DP变异在疾病发病机制中的作用”以及它们在个体化疾病管理方面的潜在作用。“