干扰素诱导的跨膜蛋白-3 rs12252-CC与肝细胞癌的低分化和进展

StephenW

Medicine (Baltimore). 2019 Jan;98(2):e13996. doi: 10.1097/MD.0000000000013996.
Interferon-induced transmembrane protein-3 rs12252-CC is associated with low differentiation and progression of hepatocellular carcinoma.
Hou Y1, Zhang Y2, Qin L2, Zhang C2, Wang S3, Chen D3, Li A2, Lou J1, Yu Y1, Dong T4, Li N5, Zhao Y1.
Author information

1
    Clinical Laboratory Center.
2
    Bioinformation Center, Beijing You'an hospital, Capital Medical University.
3
    Beijing Institute of Hepatology, Beijing You'an Hospital Affiliated to Capital Medical University, Beijing, China.
4
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, UK.
5
    STD/AIDS Research Center, Department of Medicine, Beijing You'an Hospital, Capital Medical University, Beijing, China.

Abstract

Interferon-induced transmembrane protein 3 (IFITM3) is a component of ISG (Interferon-Stimulated Gene) family. The association between IFITM3 and hepatocellular carcinoma (HCC) has been reported. While the relationship between this genetic variation and the progress of HCC remains unclear. To address this issue, we explore the relationship between the IFITM3-rs12252 genetic variants and the progression of HCC in this study.A total of 336 candidates were enrolled in the study, including 156 patients with HBV related HCC and 180 patients with chronic Hepatitis B infections or liver cirrhosis. Liver cirrhosis or chronic hepatitis B were diagnosed with clinical characteristics and staging, laboratory testing, and imaging results of viral infection and hepatic damage. Polymerase chain reaction (PCR) was employed to determine the gene polymorphism of IFITM3, and analyzed with the GraphPad Prism v 5.The patients with HCC had a significantly higher proportion of IFITM3 rs12252-CC as compared with the patients with chronic HBV infection or liver cirrhosis. Moreover, the distribution of CC genotype in HCC patients with low differentiation was significantly higher than that in those with high differentiation. Furthermore, the patients with CC genotype were found with bigger tumor size, higher percentage of vascular thrombosis, higher distribution of low differentiation and higher 5-year relapse rate than those with CT/TT genotypes.This study indicates a correlation between the IFITM3-rs12252 CC genotype and the progression of HCC.

PMID:
    30633185
DOI:
    10.1097/MD.0000000000013996

StephenW

医学（巴尔的摩）。 2019年1月; 98（2）：e13996。 doi：10.1097 / MD.0000000000013996。
干扰素诱导的跨膜蛋白-3 rs12252-CC与肝细胞癌的低分化和进展相关。
侯Y1，张Y2，秦L2，张C2，王S3，陈D3，李A2，楼J1，于玉1，董T4，李娜5，赵Y1。
作者信息

1
    临床实验中心。
2
    首都医科大学附属北京佑安医院生物信息中心。
3
    北京首都医科​​大学附属北京佑安医院北京肝病研究所，北京
4
    MRC人类免疫学单位，英国牛津大学Weatherall分子医学研究所。
五
    首都医科大学附属北京佑安医院医学科性病艾滋病研究中心，北京

抽象

干扰素诱导的跨膜蛋白3（IFITM3）是ISG（干扰素刺激的基因）家族的组分。已经报道了IFITM3与肝细胞癌（HCC）之间的关联。虽然这种遗传变异与HCC进展之间的关系仍不清楚。为了解决这个问题，我们在本研究中探讨了IFITM3-rs12252遗传变异与HCC进展之间的关系。共有336名候选人参加了该研究，其中包括156名HBV相关HCC患者和180名慢性乙型肝炎患者。感染或肝硬化。肝硬化或慢性乙型肝炎被诊断为具有临床特征和分期，实验室检测以及病毒感染和肝损伤的成像结果。聚合酶链反应（PCR）用于确定IFITM3的基因多态性，并用GraphPad Prism v5进行分析。与慢性HBV感染或肝脏患者相比，HCC患者的IFITM3 rs12252-CC比例显着更高。肝硬化。此外，分化程度低的HCC患者CC基因型分布明显高于高分化患者。此外，CC基因型患者的肿瘤体积更大，血管血栓形成率更高，分化程度更低，5年复发率高于CT / TT基因型。本研究表明IFITM3-rs12252具有相关性。 CC基因型和HCC的进展。

结论：
    30633185
DOI：
    10.1097 / MD.0000000000013996