慢性乙型肝炎病毒感染孕妇宫内传播的发生率及危险因素

StephenW

Journal Summaries in Infectious Disease
Incidence and risk factors of intrauterine transmission among pregnant women with chronic hepatitis B virus infection

Journal of Clinical Gastroenterology — Peng S, et al. | January 04, 2019

Researchers sought to determine the incidence of hepatitis B virus (HBV) intrauterine transmission in this prospective study of hepatitis B surface antigen–positive pregnant women who delivered from June 2012 to December 2016 at Wuhan Medical Care Center for Women and Children, Wuhan, China. Further, they sought the potential risk factors of HBV intrauterine transmission among these women. They noted 11 (0.9%) infants with intrauterine transmission among 1,200 women paired with 1,219 infants. Findings revealed that increasing maternal viral load can forecast intrauterine HBV transmission; the predictive rates of intrauterine transmission were 0.06%, 0.50%, 2.81%, 8.89% in infants with maternal HBV DNA levels of 105, 106, 107, 108 copies/mL, respectively. Increased risk of HBV transmission in infants was noted with vaginal delivery compared with cesarean section.

StephenW

传染病杂志综述
慢性乙型肝炎病毒感染孕妇宫内传播的发生率及危险因素

临床胃肠病学杂志 - 彭思，等。 | 2019年1月4日

研究人员试图在2012年6月至2016年12月在中国武汉武汉妇女儿童医疗中心进行的乙型肝炎表面抗原阳性孕妇前瞻性研究中确定乙型肝炎病毒（HBV）宫内传播的发生率。此外，他们还在寻找这些女性中HBV宫内传播的潜在危险因素。他们指出，有1,200名女性与1,219名婴儿配对，有11名（0.9％）胎儿宫内传播的婴儿。调查结果显示，增加母体病毒载量可预测宫内HBV传播;母体HBV DNA水平分别为105,106,107,108拷贝/ mL的婴儿宫内传播预测率分别为0.06％，0.50％，2.81％，8.89％。与剖宫产相比，阴道分娩时婴儿HBV传播风险增加。