定期剧烈运动可降低患肝癌的风险

StephenW

Regular vigorous exercise reduces liver cancer risk

Baumeister SE, et al. J Hepatol. 2018;doi:10.1016/j.jhep.2018.12.014.
January 3, 2019

Regular vigorous physical activity reduced the risk for hepatocellular carcinoma by approximately 45%, according to recently published data.

“The distribution of HCC varies greatly according to geographic location and it is more common in low- and middle-income countries than in developed countries,” Sebastian E. Baumeister, PhD, from the University of Greifswald in Germany, and colleagues wrote. “The recent increase in HCC incidence is thought to be caused by increases in obesity, diabetes, and physical inactivity.”


Baumeister and colleagues gathered data from the European Prospective Investigation into Cancer and Nutrition cohort to assess the relationship between physical activity and liver-related cancers. Of the 467,336 cohort participants, 275 developed HCC over a median follow-up of 14.9 years.

Participants who reported any physical activity were significantly less likely to develop HCC compared with those who indicated themselves ‘inactive’ (HR = 0.55; 95% CI, 0.39-0.8).

Those who reported more than 2 hours of vigorous activity per week were even less likely to develop HCC compared with those who reported no vigorous activity (HR = 0.5; 95% CI, 0.33-0.76).

The researchers also found that waist circumference correlated with 40% and BMI correlated with 30% of the overall association between total physical activity and HCC risk. Waist circumference mediated the total effect of vigorous physical activity on HCC by 17% and BMI by 12%.

According to Baumeister and colleagues, the mechanisms underlying the association between central obesity and HCC may occur through accumulation of excessive liver fat that increases pro-inflammatory molecules, leptin and adiponectin.

Additionally, the researchers found that the associations between physical activity and HCC did not differ substantially between subgroups based on sex, lifestyle or anthropometric variables.

“Studies with more detailed and objectively measured physical activity assessed at multiple time points throughout the life course are warranted to confirm our findings and may help establish the optimal dose, type, intensity, and timing of physical activity that is needed to prevent HCC,” Baumeister and colleagues wrote. – by Talitha Bennett

Disclosure: The authors report no relevant financial disclosures.

StephenW

定期剧烈运动可降低患肝癌的风险

Baumeister SE，et al。 J Hepatol。 2018; DOI：10.1016 / j.jhep.2018.12.014。
2019年1月3日

根据最近公布的数据，定期剧烈的体力活动可将肝细胞癌的风险降低约45％。

“HCC的分布根据地理位置的不同而有很大差异，在低收入和中等收入国家比在发达国家更为常见，”来自德国格赖夫斯瓦尔德大学的Sebastian E. Baumeister博士及其同事写道。 “最近HCC发病率的增加被认为是由肥胖，糖尿病和缺乏身体活动的增加引起的。”


Baumeister及其同事收集了欧洲前瞻性癌症和营养调查组的数据，以评估体力活动与肝脏相关癌症之间的关系。在467,336名队列参与者中，275名患者在中位随访时间为14。9年时发生了HCC。

报告任何身体活动的参与者发生HCC的可能性显着低于表明自己“无活动”的人（HR = 0.55; 95％CI，0.39-0.8）。

那些报告每周活动时间超过2小时的人与那些没有剧烈活动的人相比，发生HCC的可能性更小（HR = 0.5; 95％CI，0.33-0.76）。

研究人员还发现腰围与40％相关，而BMI与总体力活动与HCC风险之间总体关联的30％相关。腰围介导剧烈体力活动对HCC的总效应为17％，BMI为12％。

根据Baumeister及其同事的观点，中枢性肥胖与HCC之间关联的机制可能是通过积累过多的肝脏脂肪来增加促进炎症分子，瘦素和脂联素。

此外，研究人员发现，基于性别，生活方式或人体测量变量的亚组之间，身体活动与HCC之间的关联没有显着差异。

“在整个生命过程的多个时间点评估更详细和客观测量的身体活动的研究有必要确认我们的研究结果，并可能有助于确定预防HCC所需的最佳剂量，类型，强度和体力活动时间，”鲍迈斯特及其同事写道。 -  Talitha Bennett

披露：作者报告没有相关的财务披露。