中性粒细胞 - 淋巴细胞比率和平均血小板体积作为慢性乙型

StephenW

Ann Agric Environ Med. 2018 Dec 20;25(4):690-692. doi: 10.26444/aaem/99583. Epub 2018 Dec 4.
Neutrophil-lymphocyte ratio and mean platelet volume as predictive factors for liver fibrosis and steatosis in patients with chronic hepatitis B.
Pokora Rodak A1, Kiciak S2, Tomasiewicz K3.
Author information

1
    Department and Clinic of Infectious Diseases, Medical University of Lublin, Poland. [email protected].
2
    Department and Clinic of Infectious Diseases, Medical University of Lublin, Poland. [email protected].
3
    Department and Clinic of Infectious Diseases, Medical University of Lublin, Poland. [email protected].

Abstract
OBJECTIVE:

Evaluation of the neutrophil-lymphocyte ratio and mean platelet volume as predictive factors for liver fibrosis and steatosis in HBV patients qualified for antiviral treatment.
MATERIAL AND METHODS:

The study comprised 38 CHB patients who had commenced antiviral treatment, and 20 healthy volunteers who constituted the clinical control group. All patients had their blood count taken and underwent hepatic assessment using transient elastography with CAP (controlled attenuation parameter).
RESULTS:

It was found that the mean hepatic fibrosis was 8.7 kPa (±8.8) and the mean liver steatosis - 286 db/m (±64). Mean NLR - 2.78(±1.1), whereas in the control group the mean NLR value was 1.64(±0.98). A negative linear correlation (r= -0.34; p=0.035) was found between liver fibrosis and the NLR value in the study group. No correlation was observed between hepatic steatosis and the NLR. Mean MPV - 12.6fl (±3.1), which was considerably higher in the CBH patients than in the control group. A positive correlation (r= 0.79, p= 0.001) was found between MPV and disease severity evaluated with transient elastography.
CONCLUSIONS:

The NLR and the MPV were significantly higher in the CHB patients than in the healthy volunteers. Both the NLR and the MPV can be treated as predictive factors for liver fibrosis in this group of patients.
KEYWORDS:

hepatitis B; liver fibrosis; liver steatosis; neutrophil-lymphocyte ratio

PMID:
    30586966
DOI:
    10.26444/aaem/99583

StephenW

Ann Agric Environ Med。 2018年12月20日; 25（4）：690-692。 doi：10.26444 / aaem / 99583。 Epub 2018年12月4日。
中性粒细胞 - 淋巴细胞比率和平均血小板体积作为慢性乙型肝炎患者肝纤维化和脂肪变性的预测因素。
Pokora Rodak A1，Kiciak S2，Tomasiewicz K3。
作者信息

1
    波兰卢布林医科大学传染病科和诊所。 [email protected]。
2
    波兰卢布林医科大学传染病科和诊所。 [email protected]。
3
    波兰卢布林医科大学传染病科和诊所。 [email protected]。

抽象
目的：

评估中性粒细胞 - 淋巴细胞比率和平均血小板体积作为适合抗病毒治疗的HBV患者的肝纤维化和脂肪变性的预测因素。
材料与方法：

该研究包括38名开始抗病毒治疗的CHB患者和20名构成临床对照组的健康志愿者。所有患者均采集血细胞计数，并使用CAP（受控衰减参数）进行瞬时弹性成像进行肝脏评估。
结果：

结果发现，平均肝纤维化为8.7 kPa（±8.8），平均肝脏脂肪变性为286 db / m（±64）。平均NLR  -  2.78（±1.1），而在对照组中，平均NLR值为1.64（±0.98）。在研究组中肝纤维化和NLR值之间发现负线性相关（r = -0.34; p = 0.035）。在肝脏脂肪变性和NLR之间没有观察到相关性。平均MPV-12.6fl（±3.1），其在CBH患者中显着高于对照组。在MPV和用瞬时弹性成像评估的疾病严重程度之间发现正相关（r = 0.79，p = 0.001）。
结论：

CHB患者的NLR和MPV显着高于健康志愿者。 NLR和MPV均可作为该组患者肝纤维化的预测因素。
关键词：

乙型肝炎;肝纤维化;肝脏脂肪变性;中性粒细胞 - 淋巴细胞比率

结论：
    30586966
DOI：
    10.26444 / AAEM / 99583

StephenW

http://www.aaem.pl/The-neutrophi ... -for,99583,0,2.html

小牡丹

太专业，看不懂。请大师把结论用通俗的语言讲讲，计算方法说明。