慢性乙型肝炎自然史中乙型肝炎核心抗体水平的特征

StephenW

Discov Med. 2018 Oct;26(143):119-125.
Characteristics of hepatitis B core antibody level in the natural history of chronic hepatitis B.
Wang J#1, Yan X#1, Chen Y2, Liu Y2, Wang L3, Jia B1, Wang G3, Xiong Y3, Song P3, Wu W3, Xia J3, Lu S3, Zhang Z3, Huang R3, Wu C3.
Author information

1
    Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu 210008, China.
2
    Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
3
    Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
#
    Contributed equally

Abstract
OBJECTIVE:

We aimed to analyze serum antibody to hepatitis B core antigen (anti-HBc) level during different immunological phases in the natural history of patients with chronic hepatitis B (CHB).
METHODS:

Serum anti-HBc levels in the immune tolerant (IT), immune clearance (IC), low replicative (LR), and HBeAg negative hepatitis (ENH) phases from 634 treatment-naïve CHB patients were measured and compared between phases and with other serum markers.
RESULTS:

Median serum anti-HBc levels were different between the phases of CHB. Serum anti-HBc level was highest in the ENH phase and lowest in the IT phase. Serum anti-HBc level correlated only with ALT in the IC phase (r = 0.248, p < 0.001). The area under the receiver operating characteristic curve (AUC) of anti-HBc at a cutoff value of 9.03 S/CO for differentiation of IT and IC phases was 0.689 (sensitivity 74.03%, specificity 60.23%). The AUC for differentiation of LR and ENH phases was 0.751 (sensitivity 68.32%, specificity 70.53%) at a cutoff value of 9.74 S/CO for anti-HBc.
CONCLUSIONS:

Serum anti-HBc levels were significantly different across different phases of CHB and were associated with hepatitis activities.

PMID:
    30586535

StephenW

Discov Med。 2018年10月; 26（143）：119-125。
慢性乙型肝炎自然史中乙型肝炎核心抗体水平的特征
Wang J＃1，Yan X＃1，Chen Y2，Liu Y2，Wang L3，Jia B1，Wang G3，Xiong Y3，Song P3，Wu W3，Xia J3，Lu S3，Zhang Z3，Huang R3，Wu C3。
作者信息

1
    南京医科大学南京鼓楼医院临床医学院传染病科，江苏南京210008
2
    南京大学医学院南京鼓楼医院检验科，江苏南京210008
3
    南京大学医学院南京鼓楼医院感染科，江苏南京210008
＃
    贡献一致

抽象
目的：

我们的目的是分析慢性乙型肝炎（CHB）患者自然史中不同免疫阶段的乙型肝炎核心抗原（抗-HBc）水平的血清抗体。
方法：

测量了来自634名未接受过治疗的CHB患者的免疫耐受（IT），免疫清除（IC），低复制（LR）和HBeAg阴性肝炎（ENH）阶段的血清抗-HBc水平，并比较了各阶段和其他血清标记。
结果：

CHB期间中位血清抗-HBc水平不同。血清抗-HBc水平在ENH期最高，在IT期最低。血清抗-HBc水平仅与IC期ALT相关（r = 0.248，p <0.001）。对于IT和IC期的分化，抗-HBc的接收器操作特征曲线（AUC）在截止值9.03S / CO下的面积为0.689（灵敏度74.03％，特异性60.23％）。在抗-HBc的截断值为9.74S / CO时，LR和ENH期的分化AUC为0.751（灵敏度68.32％，特异性70.53％）。
结论：

血清抗-HBc水平在CHB的不同阶段有显着差异，并且与肝炎活动有关。

结论：
    30586535