可溶性程序性死亡-1是慢性乙型肝炎炎症和纤维化严重程度的

StephenW

J Viral Hepat. 2018 Dec 22. doi: 10.1111/jvh.13055. [Epub ahead of print]
Soluble Programmed Death-1 Is a Useful Indicator for Inflammatory and Fibrosis Severity in Chronic Hepatitis B.
Zhou L1,2, Li X1, Huang X3, Chen L1, Gu L3, Huang Y1,3.
Author information

1
    Department of Infectious Disease, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
2
    Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
3
    Guangdong Provincial Key Laboratory of Liver Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Abstract

Elevated programmed death-1 (PD-1) has been found in immune cells in viral infections and plays an important role in infection persistence. The soluble form of PD-1 (sPD-1) is involved in tumors and viral infections. The aim of this study was to investigate the role of sPD-1 in chronic hepatitis B (CHB). A total of two hundred and eighteen CHB patients and sixty healthy controls (HC) were enrolled. Demographic data and clinical parameters were collected. An ELISA assay was used to measure serum sPD-1 levels, and the relationships between sPD-1 and clinical/virological characteristics were analyzed. sPD-1 levels in CHB patients were higher (median 4.409 IQR 3.435-5.306 pg/mL) than those of HC individuals (median 0.3665 IQR 0.2425-0.5010 pg/mL). Among patients at various disease stages, patients with immune activity showed the highest sPD-1 levels (median 5.138 IQR 4.329-5.406 pg/mL). sPD-1 concentration was associated with HBV markers (HBsAg, HBV DNA and HBeAg) and biochemical parameters [serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBil), and gamma glutamyl transferase (γ-GT) levels] (all p<0.05). sPD-1 levels were higher in CHB patients with moderate-to-severe inflammation or fibrosis than in those with mild inflammation or fibrosis, regardless of ALT levels. The association between sPD-1 and disease progression of CHB suggests that sPD-1 could serve as a new indicator in assessing liver fibrosis. These findings may further aid in determining the initiation of anti-viral treatment in patients with normal ALT levels. This article is protected by copyright. All rights reserved.
KEYWORDS:

Anti-viral treatment; Hepatitis B surface antigen; Hepatitis B virus

PMID:
    30578715
DOI:
    10.1111/jvh.13055

StephenW

J病毒肝病。 2018年12月22日doi：10.1111 / jvh.13055。 [提前打印]
可溶性程序性死亡-1是慢性乙型肝炎炎症和纤维化严重程度的有用指标。
周L1,2，李X1，黄X3，陈L1，顾L3，黄Y 1,3。
作者信息

1
    中山大学附属第三医院传染病科，广州
2
    广州医科大学附属第一医院重症医学科，广州
3
    中山大学附属第三医院广东省肝脏研究重点实验室，广州

抽象

在病毒感染的免疫细胞中发现了升高的程序性死亡-1（PD-1），并且在感染持续性中起重要作用。可溶形式的PD-1（sPD-1）参与肿瘤和病毒感染。本研究的目的是研究sPD-1在慢性乙型肝炎（CHB）中的作用。共招募了二百一十八名CHB患者和六十名健康对照（HC）。收集人口统计学数据和临床参数。使用ELISA测定法测量血清sPD-1水平，并分析sPD-1与临床/病毒学特征之间的关系。 CHB患者的sPD-1水平高于HC患者（中位数4.409 IQR 3.435-5.306 pg / mL）（中位数0.3665 IQR 0.2425-0.5010 pg / mL）。在不同疾病阶段的患者中，具有免疫活性的患者显示出最高的sPD-1水平（中位数5.138 IQR 4.329-5.406pg / mL）。 sPD-1浓度与HBV标志物（HBsAg，HBV DNA和HBeAg）和生化参数[血清天冬氨酸氨基转移酶（AST），丙氨酸氨基转移酶（ALT），总胆红素（TBil）和γ谷氨酰转移酶（γ-GT）水平相关]（所有p <0.05）。无论ALT水平如何，中度至重度炎症或纤维化的CHB患者的sPD-1水平高于轻度炎症或纤维化患者。 sPD-1与CHB疾病进展之间的关联表明sPD-1可作为评估肝纤维化的新指标。这些发现可能进一步有助于确定ALT水平正常的患者开始抗病毒治疗。本文受版权保护。版权所有。
关键词：

抗病毒治疗;乙型肝炎表面抗原;乙型肝炎病毒

结论：
    30578715
DOI：
    10.1111 / jvh.13055