定量乙型肝炎表面抗原预测出生于抗原阳性母亲的婴儿的乙

StephenW

J Clin Gastroenterol. 2018 Dec 19. doi: 10.1097/MCG.0000000000001158. [Epub ahead of print]
Quantitative Hepatitis B Surface Antigen Predicts Hepatitis B Transmission in Infants Born to e Antigen-positive Mothers.
Peng S1,2, Wan Z1,2, Liu T1,2, Wang Y1,2, Chen H1,2, Li X1,2, Du Y1,2.
Author information

1
    Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology.
2
    Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Abstract
GOALS:

This study aimed to explore whether quantitative surface antigen [hepatitis B surface antigen (HBsAg)] can be used as a surrogate marker of hepatitis B virus (HBV) DNA to predict hepatitis B transmission before the first hepatitis vaccine dose in infants born to hepatitis B e antigen (HBeAg)-positive pregnant women.
BACKGROUND:

Currently, HBV transmission persistently occurs worldwide, especially in infants born to e antigen (HBeAg)-positive highly viremic mothers. However, due to high cost, the extensive use of viral load testing to identify these high-risk mothers is limited.
MATERIALS AND METHODS:

In total of 275 HBeAg-positive pregnant women paired with 280 infants were enrolled in this study. Quantitative HBsAg and HBV DNA levels were measured in the third trimester. Spearman rank correlation was used to assess the correlation between HBsAg levels and viral load, and multivariate logistic regression to identify factors related to HBV transmission in infants.
RESULTS:

Among 280 infants included, 15 (5.4%) infants were infected with HBV. In this study, we observed that quantitative HBsAg was positively correlated with maternal viral load (r=0.70, P<0.001) and highly predicted HBV transmission in infants born to HBeAg-positive mothers with area under the curve of 0.76 (95% confidence interval, 0.71-0.81). The optimum threshold HBsAg levels above 4.6 log10 IU/mL to predict HBV transmission in infants had a sensitivity of 80.0%, specificity of 67.9%.
CONCLUSIONS:

Quantitative HBsAg could be used as a surrogate marker of HBV DNA levels to predict hepatitis B transmission occurring before the injection of first-dose vaccine in infants born to e antigen-positive mothers.

PMID:
    30575631
DOI:
    10.1097/MCG.0000000000001158

StephenW

J Clin Gastroenterol。 2018年12月19日doi：10.1097 / MCG.0000000000001158。 [提前打印]
定量乙型肝炎表面抗原预测出生于抗原阳性母亲的婴儿的乙型肝炎传播。
Peng S1,2，Wan Z1,2，Liu T1,2，Wang Y1,2，Chen H1,2，Li X1,2，Du Y1,2。
作者信息

1
    华中科技大学同济医学院公共卫生学院妇幼保健系。
2
    华中科技大学同济医学院公共卫生学院环境与健康教育部环境与健康教育部重点实验室，环境健康国家重点实验室，孵化，武汉

抽象
目标：

本研究旨在探讨定量表面抗原[乙型肝炎表面抗原（HBsAg）]是否可用作乙型肝炎病毒（HBV）DNA的替代标志物，以预测乙型肝炎患儿首次接种肝炎疫苗前的乙肝传播情况e抗原（HBeAg）阳性孕妇。
背景：

目前，HBV传播在世界范围内持续发生，特别是在e抗原（HBeAg）阳性高病毒血症母亲所生的婴儿中。然而，由于成本高，广泛使用病毒载量测试来识别这些高危母亲是有限的。
材料和方法：

共有275名HBeAg阳性孕妇与280名婴儿配对参加本研究。在妊娠晚期测量定量HBsAg和HBV DNA水平。 Spearman等级相关性用于评估HBsAg水平与病毒载量之间的相关性，以及多变量逻辑回归以确定与婴儿HBV传播相关的因素。
结果：

在包括的280名婴儿中，15名（5.4％）婴儿感染了HBV。在这项研究中，我们观察到HBsAg定量与母体病毒载量正相关（r = 0.70，P <0.001），并且HBeAg阳性母亲所生婴儿的HBV传播高度预测，面积曲线为0.76（95％置信区间） ，0.71-0.81）。预测婴儿HBV传播的最佳阈值HBsAg水平高于4.6 log10 IU / mL，敏感性为80.0％，特异性为67.9％。
结论：

定量HBsAg可用作HBV DNA水平的替代标志物，以预测在e抗原阳性母亲所生婴儿中注射第一剂疫苗之前发生的乙型肝炎传播。

结论：
    30575631
DOI：
    10.1097 / MCG.0000000000001158