血清肝酶与全因死亡率之间的关系：日本公共卫生中心的前

StephenW

Liver Int. 2018 Dec 19. doi: 10.1111/liv.14030. [Epub ahead of print]
Association between serum liver enzymes and all-cause mortality: the Japan Public Health Center-based Prospective Study.
Yuwaki K1,2, Shimazu T1, Yamagiwa Y1, Inoue M1, Goto A1, Yamaji T1, Iwasaki M1, Sawada N1, Tsugane S1; JPHC Study Group.
Author information

1
    Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
2
    Underwriting and Medical Department, The Dai-ichi Life Insurance Company, Limited, 3-2-3 Toyosu, Koto-ku, Tokyo, 135-8120, Japan.

Abstract
BACKGROUND & AIMS:

The association of serum liver enzyme levels with all-cause mortality in individuals without hepatitis B virus or hepatitis C virus infection is inconsistent. We aimed to investigate all-cause and non-liver disease mortality according to levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyltransferase (GGT) stratified by hepatitis virus infection status in a Japanese cohort.
METHODS:

Participants were 7243 men and 13 513 women aged 40-69 years at the baseline survey in 1993-1994. Multivariate-adjusted hazard ratios (HRs) of death from the baseline health checkup to December 2012 were calculated with a Cox proportional hazards model controlling for potential confounding factors.
RESULTS:

During follow-up, 2235 deaths in men and 1901 deaths in women were identified. All serum liver enzymes were associated with all-cause mortality in each sex and hepatitis virus infection status. In participants without infection, those with more than twice the upper level of normal (ULN), which was defined as 30 IU/l for AST and ALT and 50 IU/l for GGT, had a higher risk of non-liver disease mortality compared to those below the ULN (HR 1.69; 95% confidence interval 1.13-2.53, 1.49; 1.02-2.18, 1.39; 1.11-1.73, 1.72; 1.08-2.74, and 1.72; 1.10-2.69 for AST, ALT, and GGT in men and AST and GGT in women, respectively), except for ALT in women.
CONCLUSIONS:

In participants without hepatitis virus infection, serum liver enzyme levels were positively associated with all-cause mortality. Similar associations were also found for non-liver disease mortality. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.
KEYWORDS:

Hepatitis viruses; Mortality; Prospective studies; Transferase

PMID:
    30566759
DOI:
    10.1111/liv.14030

StephenW

肝脏国际2018年12月19日doi：10.1111 / liv.14030。 [提前打印]
血清肝酶与全因死亡率之间的关系：日本公共卫生中心的前瞻性研究。
Yuwaki K1,2，Shimazu T1，Yamagiwa Y1，Inoue M1，Goto A1，Yamaji T1，Iwasaki M1，Sawada N1，Tsugane S1; JPHC研究组。
作者信息

1
    流行病学和预防小组，公共卫生科学中心，国立癌症中心，日本东京都中央区筑地5-1-1，104-0045。
2
    日本东京都江东区3-2-3 Toyosu，Dai-ichi Life Insurance Company，Limited的承销和医疗部门，135-8120。

抽象
背景与目的：

没有乙型肝炎病毒或丙型肝炎病毒感染的个体血清肝酶水平与全因死亡率的关系不一致。我们的目的是根据日本队列中肝炎病毒感染状况分层的血清天冬氨酸氨基转移酶（AST），丙氨酸氨基转移酶（ALT）和γ-谷氨酰转移酶（GGT）的水平来调查全因和非肝病死亡率。
方法：

在1993  -  1994年的基线调查中，参与者为7243名男性和13 513名年龄在40-69岁的女性。从基线健康检查到2012年12月的死亡的多变量校正风险比（HRs）是通过控制潜在混杂因素的Cox比例风险模型计算的。
结果：

在随访期间，确定了2235名男性死亡和1901名女性死亡。所有血清肝酶都与每种性别和肝炎病毒感染状态的全因死亡率相关。在没有感染的参与者中，那些高于正常水平（ULN）两倍的人（AST和ALT定义为30 IU / l，GGT定义为50 IU / l）与非肝病死亡率相比具有更高的风险对于那些低于ULN（HR 1.69; 95％置信区间1.13-2.53,1.49; 1.02-2.18,1.39; 1.11-1.73,1.72; 1.08-2.74和1.72; 1.10-2.69，男性AST，ALT和GGT）除妇女的ALT外，女性的AST和GGT分别为女性。
结论：

在没有肝炎病毒感染的参与者中，血清肝酶水平与全因死亡率呈正相关。对于非肝病死亡率也发现了类似的关联。本文受版权保护。版权所有。

本文受版权保护。版权所有。
关键词：

肝炎病毒;死亡;前瞻性研究;转移

结论：
    30566759
DOI：
    10.1111 / liv.14030