年龄 - 胆红素 - 国际标准化比值 - 肌酐评分在急性慢性乙型

StephenW

Cell Physiol Biochem. 2018;51(5):2484-2495. doi: 10.1159/000495904. Epub 2018 Dec 11.
Predictive Value of Age-Bilirubin-International Normalized Ratio-Creatinine Score in Short-Term Survival of Acute-on-Chronic Hepatitis B Liver Failure.
Chen L1,2, Zheng J1,2, Cai J1,2, Jie Y2,3, Zhang Y1,2, Li H1,2, Lu T1,2, He L4, Xiao C2,5, Zeng K1,2, Fu H1,2, Li H1,2, Ouyang B6, Chen G1,2, Yao J7,8, Gong J9, Yang Y1,2.
Author information

1
    Department of Hepatic Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangdong, China.
2
    Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver disease biotherapy and Translational Medicine of Guangdong Higher Education Institute, The Third Affiliated Hospital, Sun Yat-sen University, Guangdong, China.
3
    Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen Universit, Guangdong, China.
4
    Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangdong, China.
5
    Biological Therapy Center, The Third Affiliated Hospital, Sun Yat-sen University, Guangdong, China.
6
    Department of Andrology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangdong, China.
7
    Department of Hepatic Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangdong, [email protected].
8
    Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver disease biotherapy and Translational Medicine of Guangdong Higher Education Institute, The Third Affiliated Hospital, Sun Yat-sen University, Guangdong, [email protected].
9
    Department of Laboratory Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangdong, Guangdong, China.

Abstract
BACKGROUND/AIMS:

The age-bilirubin-international normalized ratio-creatinine (ABIC) score, which is a predictive model commonly used for alcoholic hepatitis, has not yet been studied in acute-on-chronic hepatitis B liver failure (HBV-ACLF). We aimed to investigate the predictive value of the ABIC score in patients with HBV-ACLF.
METHODS:

This retrospective study involved 398 patients diagnosed with HBV-ACLF, who were divided into a training cohort of 305 patients and a validation cohort of 93 patients. Univariate and multivariate Cox regression models were used to determine risk factors for mortality. Area under the receiver operating characteristic curve (AUC) was calculated to estimate and compare the predictive values of different prognostic scores.
RESULTS:

The ABIC score was significantly higher in the death group of the training cohort than in its survival group. Independent risk factors for mortality identified by multivariate Cox analysis included blood urea nitrogen, ABIC score, and Chronic Liver Failure Consortium Organ Failure (CLIF-C OF) score. For predicting 1- and 3-month mortality, AUC was higher for the ABIC score than for the Model for End-stage Liver Diseases (MELD) score (0.732 vs. 0.653, P < 0.05, 0.695 vs. 0.619, P < 0.05, respectively), CLIF-C OF score (0.693, P=0.353, 0.656, P=0.341, respectively), and Child-Pugh score (0.675, P=0.189, 0.656, P=0.300, Respectively). Patients with ABIC score > 9.44 had reduced 1- and 3-month survival rates.
CONCLUSION:

ABIC score is superior to MELD score in predicting short-term survival in HBV-ACLF patients. ABIC score > 9.44 predicts high short-term mortality risk in HBV-ACLF patients.

© 2018 The Author(s). Published by S. Karger AG, Basel.
KEYWORDS:

ABIC score; Hepatitis B virus; Liver failure; Predictor; Prognosis

PMID:
    30537748
DOI:
    10.1159/000495904

StephenW

Cell Physiol Biochem。 2018; 51（5）：2484至2495年。 doi：10.1159 / 000495904。 Epub 2018年12月11日。
年龄 - 胆红素 - 国际标准化比值 - 肌酐评分在急性慢性乙型肝炎肝衰竭短期存活中的预测价值。
Chen L1,2，Zheng J1,2，Cai J1,2，Jie Y2,3，Zhang Y1,2，Li H1,2，Lu T1,2，He L4，Xiao C2,5，Zeng K1,2，Fu H1 ，2，李H1,2，欧阳B6，陈G1,2，姚J7,8，龚J9，杨Y1,2。
作者信息

1
    中山大学附属第三医院肝外科，广东中山大学
2
    广东省中山大学附属第三医院广东省高等教育研究所肝病研究重点实验室，肝病生物治疗与转化医学重点实验室，广东，中国。
3
    中山大学附属第三医院感染科，广东中山大学
4
    广东省妇女儿童医学中心消化内科，广东
五
    中山大学附属第三医院生物治疗中心，广东中山大学
6
    华南理工大学医学院广州市第一人民医院男科，广东，中国。
7
    中山大学附属第三医院肝外科，[email protected]。
8
    广东省中山大学附属第三医院广东省高等教育研究所肝病研究重点实验室，肝病生物治疗与转化医学重点实验室，[email protected]。
9
    中山大学附属第三医院检验科，广东广东

抽象
背景/目的：

年龄 - 胆红素 - 国际标准化比率 - 肌酐（ABIC）评分是一种常用于酒精性肝炎的预测模型，尚未在急性慢性乙型肝炎肝功能衰竭（HBV-ACLF）中进行研究。我们的目的是调查ABIC评分对HBV-ACLF患者的预测价值。
方法：

这项回顾性研究涉及398名被诊断患有HBV-ACLF的患者，他们被分为305名患者的训练队列和93名患者的验证队列。单变量和多变量Cox回归模型用于确定死亡率的风险因素。计算接收器操作特征曲线下面积（AUC）以估计和比较不同预后评分的预测值。
结果：

ABIC评分在训练组的死亡组中显着高于其存活组。通过多变量Cox分析确定的死亡率的独立危险因素包括血尿素氮，ABIC评分和慢性肝衰竭联合器官衰竭（CLIF-C OF）评分。为了预测1个月和3个月的死亡率，ABIC评分的AUC高于终末期肝病模型（MELD）评分（0.732对0.653，P <0.05，0.695对0.619，P <0.05，分别），CLIF-C OF评分（分别为0.693，P = 0.353,0.656，P = 0.341）和Child-Pugh评分（0.675，P = 0.189,0.656，P = 0.300，分别）。 ABIC评分> 9.44的患者的1个月和3个月存活率降低。
结论：

在预测HBV-ACLF患者的短期存活率方面，ABIC评分优于MELD评分。 ABIC评分> 9.44预测HBV-ACLF患者的短期死亡风险较高。

©2018作者。由巴塞尔的S. Karger AG出版。
关键词：

ABIC得分;乙型肝炎病毒;肝功能衰竭;预测;预测

结论：
    30537748
DOI：
    10.1159 / 000495904

StephenW

https://www.karger.com/Article/FullText/495904