型干扰素：不同的生物活性和目前的病毒感染应用

StephenW

Cell Physiol Biochem. 2018;51(5):2377-2396. doi: 10.1159/000495897. Epub 2018 Dec 11.
Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection.
Li SF1,2, Gong MJ1,3, Zhao FR1,2, Shao JJ1,2, Xie YL1,2, Zhang YG1,2, Chang HY4,5.
Author information

1
    State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
2
    Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China.
3
    College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.
4
    State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, [email protected].
5
    Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, [email protected].

Abstract

The interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic, structural, and functional characteristics and their receptors on the cell surface. The type I IFNs are the largest group and include IFN-α, IFN-β, IFN-ε, IFN-ω, IFN-κ, IFN-δ, IFN-τ and IFN-ζ. The use of IFNs for the treatment of viral infectious diseases on their antiviral activity may become an important therapeutic option, for example, IFN-α is well known for the successful treatment of hepatitis B and C virus infections, and interest is increasing in the antiviral efficacy of other novel IFN classes and their potential applications. Therefore, in this review, we summarize the recent progress in the study of the biological activities of all the type I IFN classes and their potential applications in the treatment of infections with immunodeficiency virus, hepatitis viruses, and influenza viruses.
KEYWORDS:

Antiviral; Hepatitis; Immunodeficiency virus; Influenza Virus; Type I IFN classes; Viral infection

PMID:
    30537741
DOI:
    10.1159/000495897

StephenW

Cell Physiol Biochem。 2018; 51（5）：2377至2396年。 doi：10.1159 / 000495897。 Epub 2018年12月11日。
I型干扰素：不同的生物活性和目前的病毒感染应用。
李SF1,2，龚MJ1,3，赵FR1,2，邵JJ1,2，谢YL1,2，张YG1,2，张HY4,5。
作者信息

1
    中国农业科学院兰州兽医研究所兽医病原生物学国家重点实验室，国家口蹄疫参考实验室，兰州，中国。
2
    江苏省重庆市重大动物传染病和人畜共患病预防控制联合创新中心，扬州
3
    甘肃农业大学动物医学院，兰州，中国。
4
    中国农业科学院兰州兽医研究所兽医病原生物学国家重点实验室，国家口蹄疫参考实验室，兰州，Chinachanghuiyun @caas.cn。
五
    江苏省重庆市重大动物传染病和人畜共患病预防控制联合创新中心，Chinachanghuiyun @caas.cn。

抽象

干扰素（IFN）是对病原体的主要防御，因为它们诱导了强烈的抗病毒活性。 IFN可根据其遗传，结构和功能特征及其在细胞表面的受体分为三类：I型，II型和III型。 I型IFN是最大的组，包括IFN-α，IFN-β，IFN-ε，IFN-ω，IFN-κ，IFN-δ，IFN-τ和IFN-ζ。使用IFN来治疗病毒感染性疾病的抗病毒活性可能成为一种重要的治疗选择，例如，IFN-α因成功治疗乙型和丙型肝炎病毒感染而众所周知，并且对抗病毒药物的兴趣日益增加。其他新型IFN类的功效及其潜在应用。因此，在本综述中，我们总结了所有I型IFN类生物活性研究的最新进展及其在治疗免疫缺陷病毒，肝炎病毒和流感病毒感染中的潜在应用。
关键词：

抗病毒;肝炎;免疫缺陷病毒;流感病毒; I型IFN类;病毒感染

结论：
    30537741
DOI：
    10.1159 / 000495897

StephenW

https://www.karger.com/Article/FullText/495897