MR细胞外体积分数测量与二维剪切波弹性成像评价慢性乙型肝

StephenW

Abdom Radiol (NY). 2018 Dec 7. doi: 10.1007/s00261-018-1860-1. [Epub ahead of print]
A comparative study of MR extracellular volume fraction measurement and two-dimensional shear-wave elastography in assessment of liver fibrosis with chronic hepatitis B.
Jin K1, Wang H1, Zeng M1, Rao S1, Yan L2, Ji Y3, Fu C4, Sheng R5.
Author information

1
    Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Medical Imaging, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, People's Republic of China.
2
    Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
3
    Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
4
    Siemens Healthcare, Shanghai, 200000, People's Republic of China.
5
    Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Medical Imaging, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, People's Republic of China. [email protected].

Abstract
OBJECTIVE:

To evaluate the value of MR liver extracellular volume (ECVliver) in assessment of liver fibrosis with chronic hepatitis B (CHB), and to compare its performance with two-dimensional (2D) shear-wave elastography (SWE).
MATERIALS AND METHODS:

A total of 68 CHB patients who were histologically diagnosed as fibrosis stages F0 to F4 were retrospectively analyzed. All patients underwent gadopentetate dimeglumine-enhanced T1-mapping and 2D SWE. ECVliver and liver stiffness were measured and compared between fibrosis subgroups; their correlations with histologic findings were evaluated using Spearman correlation test and multiple regression analysis. Diagnostic performance in evaluating liver fibrosis stages was assessed and compared using receiver-operating characteristic analysis.
RESULTS:

Both ECVliver and liver stiffness increased as the fibrosis score increased (F = 17.08 to 10.99, P < 0.001). ECVliver displayed a strong correlation with fibrosis stage (r = 0.740, P < 0.001), and liver stiffness displayed a moderate correlation (r = 0.651, P < 0.001); multivariate analysis revealed that only ECVliver was independently correlated with fibrosis stage (P < 0.001). Univariate analyses showed significant correlations of ECVliver with fibrosis stage, inflammatory activity, and platelet count; among all, the fibrosis stage had the highest correlation coefficient and was the only independent factor (P < 0.001). Overall, ECVliver had no significant different performance compared with 2D SWE for the identification of both fibrosis stage s ≥ F2 and F4 (P = 0.868 and 0.171).
CONCLUSION:

MR ECVliver plays a promising role in the prediction of liver fibrosis for patients with CHB, comparable to 2D SWE.
KEYWORDS:

Chronic hepatitis B; Cirrhosis; Extracellular space; Liver fibrosis; Magnetic resonance imaging; Sonoelastography

PMID:
    30535519
DOI:
    10.1007/s00261-018-1860-1

StephenW

Abdom Radiol（纽约州）。 2018年12月7日doi：10.1007 / s00261-018-1860-1。 [提前打印]
MR细胞外体积分数测量与二维剪切波弹性成像评价慢性乙型肝炎肝纤维化的对比研究
Jin K1，Wang H1，Zeng M1，Rao S1，Yan L2，Ji Y3，Fu C4，Sheng R5。
作者信息

1
    复旦大学附属中山医院放射科，上海市徐汇区凤林路180号上海医学影像研究所，200032，中华人民共和国。
2
    复旦大学附属中山医院超声科，上海，200032，中华人民共和国。
3
    复旦大学附属中山医院病理科，上海，200032，中华人民共和国。
4
    西门子医疗集团，上海，200000，中华人民共和国。
五
    复旦大学附属中山医院放射科，上海市徐汇区凤林路180号上海医学影像研究所，200032，中华人民共和国。 [email protected]。

抽象
目的：

评估MR肝细胞外体积（ECVliver）在评估慢性乙型肝炎（CHB）肝纤维化中的价值，并将其性能与二维（2D）剪切波弹性成像（SWE）进行比较。
材料和方法：

回顾性分析了组织学诊断为纤维化分期F0至F4的68名CHB患者。所有患者均接受gadopentetate dimeglumine增强T1映射和2D SWE。测量ECVliver和肝硬度并比较纤维化亚组;使用Spearman相关检验和多元回归分析评估它们与组织学发现的相关性。评估肝纤维化阶段的诊断性能，并使用接受者操作特征分析进行比较。
结果：

随着纤维化评分的增加，ECVliver和肝硬度均增加（F = 17.08至10.99，P <0.001）。 ECVliver与纤维化分期呈显着相关（r = 0.740，P <0.001），肝硬度呈中度相关（r = 0.651，P <0.001）;多变量分析显示，只有ECVliver与纤维化分期独立相关（P <0.001）。单变量分析显示ECVliver与纤维化分期，炎症活动和血小板计数有显着相关性;其中，纤维化阶段的相关系数最高，是唯一的独立因素（P <0.001）。总体而言，与2D SWE相比，ECVliver在鉴定纤维化分期s≥F2和F4方面没有显着差异（P = 0.868和0.171）。
结论：

与2D SWE相比，MR ECVliver在CHB患者的肝纤维化预测中发挥了有希望的作用。
关键词：

慢性乙型肝炎;肝硬化;细胞外空间;肝纤维化;磁共振成像; Sonoelastography

结论：
    30535519
DOI：
    10.1007 / s00261-018-1860-1