脐带血中乙型肝炎病毒标记物的存在：接触或感染病毒？

StephenW

Dig Liver Dis. 2018 Nov 20. pii: S1590-8658(18)31222-2. doi: 10.1016/j.dld.2018.11.003. [Epub ahead of print]
Presence of hepatitis B virus markers in umbilical cord blood: Exposure to or infection with the virus?
Liu J1, Xu B2, Chen T3, Chen J4, Feng J4, Xu C3, Liu L2, Hu Y4, Zhou YH5.
Author information

1
    Department of Laboratory Medicine, Nanjing Drum Tower Hospital and Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, China.
2
    Department of Obstetrics and Gynecology, Taixing People's Hospital, Taixing, China.
3
    Department of Obstetrics and Gynecology, Zhenjiang Fourth People's Hospital, Zhenjiang, China.
4
    Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
5
    Department of Laboratory Medicine, Nanjing Drum Tower Hospital and Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, China; Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing, China. Electronic address: [email protected].

Abstract
BACKGROUND:

We aimed to clarify whether presence of hepatitis B virus (HBV) markers in cord blood indicates exposure to or infection with HBV.
METHODS:

We prospectively recruited HBsAg-positive pregnant women and their neonates 2012 through 2015. All neonates received postnatal immunoprophylaxis. The infants were followed up at 7-14 months of age.
RESULTS:

Totally 329 HBsAg-positive pregnant women and 333 neonates were enrolled. No cord blood was anti-HBc IgM positive. A total of 290 (87.1%) neonates were followed up at 7-14 months of age and 6 (2.1%) of them were infected with HBV. Of 146 neonates born to HBeAg-negative mothers, 38 (26.0%) and 30 (20.5%) had detectable HBsAg and HBV DNA in cord blood respectively, but none of 126 infants followed up was infected. Of 187 neonates born to HBeAg-positive mothers, 92 (49.2%) and 79 (42.2%) had detectable HBsAg and HBV DNA in cord blood respectively; 6 (3.7%) of 164 infants followed up were infected. Of seven neonates with HBV DNA > 105 IU/ml in cord blood, four had no infection and three others were infected.
CONCLUSION:

Presence of HBsAg and/or HBV DNA, even at high levels, in cord blood just indicates exposure to, but not infection with HBV. Presence of HBV markers in cord blood cannot define intrauterine infection.

Copyright © 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:

Anti-HBc IgM; Cord blood; HBV DNA; Hepatitis B virus; Intrauterine infection

PMID:
    30528568
DOI:
    10.1016/j.dld.2018.11.003

StephenW

Dig Liver Dis。 2018年11月20日.pii：S1590-8658（18）31222-2。 doi：10.1016 / j.dld.2018.11.003。 [提前打印]
脐带血中乙型肝炎病毒标记物的存在：接触或感染病毒？
Liu J1，Xu B2，Chen T3，Chen J4，Feng J4，Xu C3，Liu L2，Hu Y4，Zhou YH5。
作者信息

1
    南京大学医学院南京鼓楼医院检验科，江苏省分子医学重点实验室，南京
2
    泰兴市泰兴市人民医院妇产科
3
    镇江市第四人民医院妇产科，镇江
4
    南京大学医学院南京鼓楼医院妇产科，南京
五
    南京大学医学院南京鼓楼医院检验科，江苏省分子医学重点实验室，南京;南京医科大学南京鼓楼医院感染科，南京电子地址：[email protected]。

抽象
背景：

我们的目的是澄清脐带血中是否存在乙型肝炎病毒（HBV）标志物表明接触或感染HBV。
方法：

我们前瞻性地招募了2012年至2015年HBsAg阳性孕妇及其新生儿。所有新生儿均接受了产后免疫预防。婴儿在7-14个月大时进行随访。
结果：

共招募了329名HBsAg阳性孕妇和333名新生儿。没有脐带血是抗HBc IgM阳性的。共有290名（87.1％）新生儿在7-14个月时进行随访，其中6名（2.1％）感染了HBV。在HBeAg阴性母亲所生的146例新生儿中，38例（26.0％）和30例（20.5％）分别在脐带血中检测到HBsAg和HBV DNA，但126例婴儿中没有一例被感染。在HBeAg阳性母亲所生的187例新生儿中，92例（49.2％）和79例（42.2％）分别在脐带血中检测到HBsAg和HBV DNA;随访的164名婴儿中有6名（3.7％）被感染。在脐带血中HBV DNA> 105IU / ml的7名新生儿中，4名没有感染，3名感染。
结论：

在脐带血中HBsAg和/或HBV DNA的存在，即使是高水平，也只表明接触HBV，但不能感染HBV。脐带血中HBV标志物的存在不能定义宫内感染。

版权所有©2018 Editrice Gastroenterologica Italiana S.r.l.由Elsevier Ltd.出版。保留所有权利。
关键词：

抗HBc IgM;脐带血; HBV DNA;乙型肝炎病毒;宫内感染

结论：
    30528568
DOI：
    10.1016 / j.dld.2018.11.003