乙型和丙型肝炎和肝细胞癌的性别二态性

StephenW

Sexual dimorphism in hepatitis B and C and hepatocellular carcinoma; Buettner N, Thimme R; Seminars in Immunopathology (Nov 2018)

    Tags:
        Hepatitis Liver Cancer Viral Infections


The incidence of viral hepatitis B or C (HBV/HCV) infection and hepatocellular carcinoma is higher in male compared to female populations, showing a faster disease progression and results in a worse overall survival. Indeed, women are in general better protected from viral infections and show a lower risk of death from malignant cancer in comparison to men. Females mount stronger innate and adaptive immune responses than males, and therefore, most of the autoimmune diseases occur predominantly in females. Next to occupational and/or behavioral factors, cellular and molecular differences between the two sexes contribute to this observation. In this review, we will discuss underlying mechanisms that are important for the observed sex-related differences in liver diseases. A better appreciation of these differences between the two sexes might be of value for better and gender-specific treatment options.

StephenW

乙型和丙型肝炎和肝细胞癌的性别二态性; Buettner N，Thimme R;免疫病理学研讨会（2018年11月）

    标签：
        肝炎肝癌病毒感染


与女性人群相比，男性中病毒性乙型肝炎或丙型肝炎（HBV / HCV）感染和肝细胞癌的发病率更高，表明疾病进展更快并且导致更差的总体存活率。实际上，与男性相比，女性通常更好地免受病毒感染，并且表现出较低的恶性癌症死亡风险。女性比男性具有更强的先天性和适应性免疫反应，因此，大多数自身免疫性疾病主要发生在女性中。除了职业和/或行为因素之外，两性之间的细胞和分子差异也有助于这种观察。在这篇综述中，我们将讨论对观察到的与肝脏疾病有关的性别差异很重要的潜在机制。更好地了解两性之间的这些差异可能对更好和针对性别的治疗方案有价值。