膜破裂和分娩对乙型肝炎垂直传播风险的影响：前瞻性多中

StephenW

Eur J Obstet Gynecol Reprod Biol. 2018 Nov 23;232:97-100. doi: 10.1016/j.ejogrb.2018.11.017. [Epub ahead of print]
The effect of rupture of membranes and labour on the risk of hepatitis B vertical transmission: Prospective multicentre observational study.
Cheung KW1, Seto MTY2, So PL3, Wong D4, Mak ASL5, Lau WL6, Wang W2, Kan ASY2, Lee CP2, Ng EHY2.
Author information

1
    Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address: [email protected].
2
    Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region.
3
    Department of Obstetrics & Gynaecology, Tuen Mun Hospital, Hong Kong Special Administrative Region.
4
    Department of Obstetrics & Gynaecology, Pamela Youde Nethersole Eastern Hospital, Hong Kong Special Administrative Region.
5
    Department of Obstetrics & Gynaecology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region.
6
    Department of Obstetrics & Gynaecology, Kwong Wah Hospital, Hong Kong Special Administrative Region.

Abstract
OBJECTIVE:

To evaluate the effect of rupture of membranes and labour on the risk of hepatitis B virus (HBV) vertical transmission.
STUDY DESIGN:

A prospective multicentre observational study was carried out in Hong Kong between 2014-2016. Pregnant HBV carriers were recruited. The duration of rupture of membranes, labour and mode of delivery were collected prospectively. HBV DNA was examined at 28-30 weeks of gestation. All newborns received standard HBV vaccination and immunoglobulin. Hepatitis B surface antigen of infants was tested at 9-12 months of age.
RESULTS:

641 pregnancies were recruited and analyzed. No statistically significant difference was found in gravida, parity, gestational age at delivery, mode of delivery, duration of rupture of membranes, duration of labour, preterm delivery, preterm rupture of membranes or birth weight (p > 0.05). Subgroup analysis in viral load > 7log10IU/ml and 8log10IU/ml also did not find a significant association between duration of rupture of membranes and labour with immunoprophylaxis failure.
CONCLUSIONS:

Duration of rupture of membranes and labour would not affect the risk of HBV vertical transmission in infants following standard HBV vaccination and hepatitis B immunoglobulin administration.

Copyright © 2018 Elsevier B.V. All rights reserved.
KEYWORDS:

Hepatitis B virus; Immunoprophylaxis failure; Labour; Pregnancy; Rupture of membranes; Vertical infection transmission

PMID:
    30504033
DOI:
    10.1016/j.ejogrb.2018.11.017

StephenW

Eur J Obstet Gynecol Reprod Biol。 2018年11月23日; 232：97-100。 doi：10.1016 / j.ejogrb.2018.11.017。 [提前打印]
膜破裂和分娩对乙型肝炎垂直传播风险的影响：前瞻性多中心观察研究。
Cheng KW1，Seto MTY2，So PL3，Wong D4，Mak ASL5，Lau WL6，Wang W2，Kan ASY2，Lee CP2，Ng EHY2。
作者信息

1
    香港大学玛丽医院妇产科，香港特别行政区。电子地址：[email protected]。
2
    香港大学玛丽医院妇产科，香港特别行政区。
3
    香港特别行政区屯门医院妇产科。
4
    香港特别行政区东区尤德夫人那打素医院妇产科。
五
    香港特别行政区伊利沙伯医院妇产科。
6
    香港特别行政区广华医院妇产科。

抽象
目的：

评估膜破裂和分娩对乙型肝炎病毒（HBV）垂直传播风险的影响。
学习规划：

2014年至2016年期间在香港进行了一项前瞻性多中心观察研究。招募了怀孕的HBV携带者。前瞻性收集膜破裂持续时间，分娩时间和分娩方式。在妊娠28-30周检查HBV DNA。所有新生儿均接受标准HBV疫苗接种和免疫球蛋白治疗。在9-12个月龄时测试婴儿的乙型肝炎表面抗原。
结果：

招募和分析了641名怀孕。在孕妇，胎次，分娩时的孕龄，分娩方式，膜破裂持续时间，分娩持续时间，早产，早产胎膜破裂或出生体重方面均无统计学差异（p> 0.05）。病毒载量> 7log10IU / ml和8log10IU / ml的亚组分析也未发现膜破裂持续时间与免疫预防失败的分娩之间存在显着关联。
结论：

在标准HBV疫苗接种和乙型肝炎免疫球蛋白给药后，膜破裂持续时间和分娩不会影响婴儿HBV垂直传播的风险。

版权所有©2018 Elsevier B.V.保留所有权利。
关键词：

乙型肝炎病毒;免疫预防失败;劳工;怀孕;膜破裂;垂直感染传播

结论：
    30504033
DOI：
    10.1016 / j.ejogrb.2018.11.017