无活动性慢性乙型肝炎病毒感染患者的自发复发。

StephenW

Caspian J Intern Med. 2018 Fall;9(4):393-396. doi: 10.22088/cjim.9.4.393.
Spontaneous relapse in patients with inactive chronic hepatitis B virus infection.
Karajibani M1, Hasanjani Roushan MR2, Bayani M2, Javanian M2, Masrour-Roudsari J2.
Author information

1
    Department of Infectious Diseases, Babol University of Medical Sciences, Babol, Iran.
2
    Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran.

Abstract
Background:

Chronic hepatitis B virus infection (HBV) may reactivate during the course of the disease and is called spontaneous relapse. The purpose of this study was to evaluate the incidence of relapse of hepatitis in subjects with inactive HBV carriers.
Methods:

This follow-up study was performed on 785 patients with inactive HBV carriers that were followed-up at six month intervals. The presence of serum HBsAg and anti-HBe, without HBeAg, HBV DNA levels <2000 IU/ml with normal alanine aminotransferase (ALT) levels was defined as inactive carriers. Patients who developed ALT ≥80 IU/L with HBV DNA levels ≥2000 IU/ml were considered as spontaneous relapse.
Results:

Seven hundred- eighty five cases (441 males, 344 females) of chronic HBV infected individuals were followed-up. The mean age at the entrance of the study was 30.5±11.8 years. The mean follow-up duration was 5.9±5 years. Relapse was seen in 35 (4.5%) cases, in 27 out of 441 (6.1%) males and in 8 out of 344 (2.3%) females and in 4.2% subjects ≥30 years versus in 4.7% cases of under 30 years (p>0.05). The development of relapse in males was higher than females (hazard ratio 2.53, 95% CI 1.2-5.6, p=0.021), but age ≥30 or <30 years did not have effect (hazard ratio1.21, 95% CI 0.62-2.36, p=0.58).
Conclusions:

The results show that spontaneous relapse of hepatitis may develop during the course of chronic HBV infection. We suggest that all patients with chronic hepatitis B, regardless of their age, be examined for the possibility of relapse.
KEYWORDS:

Chronic; Hepatitis B; Relapse; Virus; infection

PMID:
    30510655
PMCID:
    PMC6230452
DOI:
    10.22088/cjim.9.4.393

StephenW

Caspian J Intern Med。 2018秋季; 9（4）：393-396。 doi：10.22088 / cjim.9.4.393。
无活动性慢性乙型肝炎病毒感染患者的自发复发。
Karajibani M1，Hasanjani Roushan MR2，Bayani M2，Javanian M2，Masrour-Roudsari J2。
作者信息

1
    巴布尔医科大学传染病系，伊朗巴布尔。
2
    巴布尔医科大学传染病和热带医学研究中心，伊朗巴布尔。

抽象
背景：

慢性乙型肝炎病毒感染（HBV）可能在疾病过程中重新激活，称为自发复发。本研究的目的是评估HBV携带者无活动性肝炎复发的发生率。
方法：

该随访研究对785名无活动的HBV携带者进行了随访，每6个月进行一次随访。血清HBsAg和抗HBe的存在，没有HBeAg，HBV DNA水平<2000 IU / ml，正常丙氨酸氨基转移酶（ALT）水平被定义为无活性载体。发生ALT≥80IU/ L且HBV DNA水平≥2000IU/ ml的患者被认为是自发复发。
结果：

随访了78例慢性HBV感染者（441名男性，344名女性）。研究入口处的平均年龄为30.5±11.8岁。平均随访时间为5.9±5年。 35例（4.5％）患者复发，441例（6.1％）男性中有27例，344例（2.3％）中有8例，≥30岁的4.2％受试者，而未满30年的4.7％（ p> 0.05）。男性复发的发生率高于女性（风险比2.53,95％CI 1.2-5.6，p = 0.021），但年龄≥30或<30岁没有效果（风险比率1.21,95％CI 0.62- 2.36，p = 0.58）。
结论：

结果表明，在慢性HBV感染过程中可能发生肝炎自发复发。我们建议所有慢性乙型肝炎患者，无论其年龄，都应检查复发的可能性。
关键词：

慢性;乙型肝炎;复发;病毒;感染

结论：
    30510655
PMCID：
    PMC6230452
DOI：
    10.22088 / cjim.9.4.393