急性乙型肝炎患者孵化期乙型肝炎病毒血清标志物的动态变

StephenW

Clin J Gastroenterol. 2018 Nov 21. doi: 10.1007/s12328-018-0925-6. [Epub ahead of print]
Dynamics of hepatitis B virus serum markers in an acute hepatitis B patient in the incubation phase.
Okamoto S1, Yamasaki K2, Komori A1, Abiru S1, Nagaoka S1, Saeki A1, Hashimoto S1, Bekki S1, Okamoto H3, Yatsuhashi H1.
Author information
Abstract

Patients with acute hepatitis B (AHB) usually present after developing symptoms; therefore, the temporal kinetics of viral markers during the incubation period have not been documented clearly. We describe an AHB infection before the onset of hepatitis, throughout the course of the disease and without anti-viral therapy. The patient initially visited our hospital for immunization against HBV and was found to be positive for viral markers: 0.0 IU/mL of anti-HBs, 0.06 S/CO of anti-HBc and 2.93 IU/mL of HBsAg. During the 14 days after his first visit, HBsAg, HBV DNA, HBe antigen and HBV core-related antigen, but not anti-HBc or anti-HBs, levels increased. On day 22, he developed acute hepatitis. The period of logarithmic viral replication was estimated to be 7.0 days. HBV genomic sequencing and phylogenetic analysis indicated transmission from the patient's wife. Although sexual intercourse could not be ruled, another possible route of transmission was the unusual occurrence of kissing his wife when she had macroscopic bleeding after tooth brushing, 2 months before his positive HBsAg result; the day of the episode being consistent with the calculated HBV replication velocity. This study reveals the temporal kinetics of viral markers during the incubation period of AHB.
KEYWORDS:

Acute hepatitis; HBV; HBsAg; Incubation phase

PMID:
    30465320
DOI:
    10.1007/s12328-018-0925-6

StephenW

Clin J Gastroenterol。 2018年11月21日doi：10.1007 / s12328-018-0925-6。 [提前打印]
急性乙型肝炎患者孵化期乙型肝炎病毒血清标志物的动态变化。
Okamoto S1，Yamasaki K2，小森A1，Abiru S1，Nagaoka S1，Saeki A1，Hashimoto S1，Bekki S1，Okamoto H3，Yatsuhashi H1。
作者信息
抽象

急性乙型肝炎（AHB）患者通常在出现症状后出现;因此，潜伏期间病毒标志物的时间动力学尚未清楚地记录。我们描述了在肝炎发病前，在整个疾病过程中并且没有抗病毒治疗的AHB感染。患者最初到我们医院接受HBV免疫接种，发现病毒标志物阳性：0.0IU / mL抗-HBs，0.06 S / CO抗-HBc和2.93 IU / mL HBsAg。在他第一次就诊后的第14天，HBsAg，HBV DNA，HBe抗原和HBV核心相关抗原，但不抗HBc或抗HBs水平升高。在第22天，他患上了急性肝炎。对数病毒复制的时间估计为7.0天。 HBV基因组测序和系统发育分析表明患者的妻子传播。虽然不能统治性交，但另一种可能的传播途径是在刷牙后出现肉眼可见的出血，在HBsAg阳性结果出现2个月之前，亲吻妻子的情况异常发生;该集的当天与计算的HBV复制速度一致。该研究揭示了AHB潜伏期间病毒标志物的时间动力学。
关键词：

急性肝炎; HBV;乙肝表面抗原;孵化阶段

结论：
    30465320
DOI：
    10.1007 / s12328-018-0925-6