慢性肝病患者的肌肉痉挛被忽视：与肌肉痉挛的患病率有关

StephenW

Source: Eur J Gastroenterol Hepatol  |  Posted 6 days ago
Overlooked muscle cramps in patients with chronic liver disease: in relation to the prevalence of muscle cramps; Murata A, Hyogo H, Nonaka M, Sumioka A, Suehiro Y, Furudoi A, Fujimoto Y, Aisaka Y, Komatsu H, Tokumo H; European Journal of Gastroenterology and Hepatology (Oct 2018)

    Tags:
        Cirrhosis Diabetes Hepatitis Pain Management

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INTRODUCTION Muscle cramps are common comorbidities in chronic liver disease (CLD). Although the prevalence of these has been reported in patients with liver cirrhosis (LC), that of CLD is unknown. In this study, we aimed to clarify the prevalence and characteristics of muscle cramps in individual CLD.

PATIENTS AND METHODS A total of 432 patients with CLD who visited our hospital were enrolled. The existence of muscle cramps, frequency, time zone, duration, and the degree of pain were investigated using a medical interview questionnaire.

RESULTS The median age of the patients was 65 years and 48.6% of the patients were women. The prevalence of muscle cramps was 25.9%. Age, female sex, lower BMI, existence of comorbid diseases, and liver fibrosis were associated significantly with muscle cramps. In LC, muscle cramps were significantly frequent, and the severity and duration of these were significantly stronger and longer compared with chronic hepatitis. Female sex [odds ratio (OR): 2.26; P=0.014], diabetes (OR: 29.4; P<0.001), chronic kidney disease (OR: 8.33; P=0.004), and lower BMI (OR: 0.853; P<0.001) were independent factors associated with muscle cramps in CLD. Muscle mass indices were significantly lower among nonalcoholic fatty liver disease patients with muscle cramps, female patients, elderly patients, and patients with advanced fibrosis.

CONCLUSION The prevalence of muscle cramps was relatively high in CLD. Female sex, comorbid diabetes, and chronic kidney disease are associated with muscle cramps in CLD. Furthermore, reduced muscle mass is related to muscle cramps in nonalcoholic fatty liver disease.

StephenW

来源：Eur J Gastroenterol Hepatol |发表于6天前
慢性肝病患者的肌肉痉挛被忽视：与肌肉痉挛的患病率有关; Murata A，Hyogo H，Nonaka M，Sumioka A，Suehiro Y，Furudoi A，Fujimoto Y，Aisaka Y，Komatsu H，Tokumo H;欧洲胃肠病学和肝病学杂志（2018年10月）

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        肝硬化糖尿病肝炎疼痛管理

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引言肌肉痉挛是慢性肝病（CLD）常见的合并症。虽然已报道肝硬化（LC）患者的患病率，但CLD患者尚不清楚。在这项研究中，我们旨在阐明个别CLD中肌肉痉挛的患病率和特征。

患者和方法共有432名患有CLD的患者到我们医院就诊。使用医学访谈调查表调查肌肉痉挛，频率，时区，持续时间和疼痛程度的存在。

结果患者的中位年龄为65岁，48.6％的患者为女性。肌肉痉挛的患病率为25.9％。年龄，女性，较低的BMI，合并疾病的存在和肝纤维化与肌肉痉挛显着相关。在LC中，肌肉痉挛非常频繁，并且与慢性肝炎相比，这些肌肉痉挛的严重程度和持续时间显着更强且更长。女性[比值比（OR）：2.26; P = 0.014]，糖尿病（OR：29.4; P <0.001），慢性肾脏疾病（OR：8.33; P = 0.004）和较低的BMI（OR：0.853; P <0.001）是与CLD肌肉痉挛相关的独立因素。肌肉痉挛，女性患者，老年患者和晚期纤维化患者的非酒精性脂肪肝患者的肌肉质量指数显着降低。

结论CLD患者肌肉痉挛的患病率相对较高。女性，共患糖尿病和慢性肾病与CLD的肌肉痉挛有关。此外，肌肉量减少与非酒精性脂肪性肝病的肌肉痉挛有关