提出的预测慢性乙型肝炎患者肝内共价闭合环状DNA水平的模

StephenW

Hepatol Res. 2018 Oct 25. doi: 10.1111/hepr.13280. [Epub ahead of print]
A proposed model for the prediction of intrahepatic covalently closed circular DNA level in patients with chronic hepatitis B.
Hasegawa K1, Nishikawa H1, Enomoto H1, Iwata Y1, Sakai Y1, Ikeda N1, Takashima T1, Aizawa N1, Takata R1, Yoh K1, Ishii N1, Yuri Y1, Nishimura T1, Iijima H1, Hatano E2, Fujimoto J2, Nishiguchi S1.
Author information

1
    Division of Hepatobiliary and Pancreatic disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
2
    Division of Hepatobiliary and Pancreatic disease, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

Abstract
BACKGROUND:

We sought to create a prediction model for intrahepatic covalently closed circular DNA (IH-cccDNA) level in chronic hepatitis B (CHB) patients and to validate the model's predictive accuracy.
METHODS:

Patients who did not receive previous nucleoside analogue (NA) therapy were assigned to the training cohort (n=57), and those who received previous NA therapy were assigned to the validation cohort (n=69). Factors linked to IH-cccDNA levels in the training cohort were analyzed and a formula to predict IH-cccDNA level was constructed. Next, the reproducibility of that formula was assessed.
RESULTS:

In the multivariate analysis for the prediction of IH-cccDNA level in the training cohort, fasting blood sugar (FBS) (P=0.0227), hepatitis B e antigen (HBeAg) (P=0.0067) and Log10(HB surface antigen (HBsAg)) (P=0.0497) were significant, while HB core-related antigen (HBcrAg) tended to be significant (P=0.0562). The formula named the FBS-cres score based on the variables used (FBS, HBcrAg, HBeAg and HBsAg) was constructed. FBS-cres score was calculated as: 3.1686 - (0.0148×FBS) + (0.1982×HBcrAg) + (0.0008168×HBeAg) + (0.1761×log10(HBsAg)). In the training cohort, between HBcrAg level and IH-cccDNA level, significant correlation was noted (P<0.0001, r=0.67), while the FBS-cres score was more closely correlated to IH-cccDNA level (P<0.0001, r=0.81). In the validation cohort, between HBcrAg level and IH-cccDNA level, significant correlation was found (P=0.0012, r=0.38), while the FBS-cres score was more closely linked to IH-cccDNA levels (P<0.0001, r=0.51). Similar tendencies were observed in all subgroup analyses.
CONCLUSION:

Our proposed model for the prediction of IH-cccDNA level may be helpful in CHB patients.

This article is protected by copyright. All rights reserved.
KEYWORDS:

Chronic hepatitis B; Hepatitis B core-related antigen; Hepatitis B surface antigen; Intrahepatic covalently closed circular DNA; Predictive model

PMID:
    30358027
DOI:
    10.1111/hepr.13280

StephenW

Hepatol Res。 2018年10月25日.doi：10.1111 / hepr.13280。 [提前打印]
提出的预测慢性乙型肝炎患者肝内共价闭合环状DNA水平的模型。
Hasegawa K1，Nishikawa H1，Enomoto H1，Iwata Y1，Sakai Y1，Ikeda N1，Takashima T1，Aizawa N1，Takata R1，Yoh K1，Ishii N1，Yuri Y1，Nishimura T1，Iijima H1，Hatano E2，Fujimoto J2，Nishiguchi S1 。
作者信息

1
    日本兵库县西宫市兵库医学院内科，肝胆胰疾病科
2
    日本兵库县西宫市兵库医学院外科，肝胆胰疾病科

抽象
背景：

我们试图建立慢性乙型肝炎（CHB）患者肝内共价闭合环状DNA（IH-cccDNA）水平的预测模型，并验证模型的预测准确性。
方法：

未接受过核苷类似物（NA）治疗的患者被分配到训练组（n = 57），接受过NA治疗的患者被分配到验证队列（n = 69）。分析了与训练组中IH-cccDNA水平相关的因素，并构建了预测IH-cccDNA水平的公式。接下来，评估该配方的再现性。
结果：

在多变量分析中预测训练队列中的IH-cccDNA水平，空腹血糖（FBS）（P = 0.0227），乙型肝炎e抗原（HBeAg）（P = 0.0067）和Log10（HB表面抗原（HBsAg）） （P = 0.0497）显着，而HB核心相关抗原（HBcrAg）显着（P = 0.0562）。基于所用变量（FBS，HBcrAg，HBeAg和HBsAg）构建了名为FBS-cres评分的公式。 FBS-cres评分计算如下：3.1686 - （0.0148×FBS）+（0.1982×HBcrAg）+（0.0008168×HBeAg）+（0.1761×log10（HBsAg））。在训练组中，HBcrAg水平与IH-cccDNA水平之间存在显着相关性（P <0.0001，r = 0.67），而FBS-cres评分与IH-cccDNA水平密切相关（P <0.0001，r = 0.81）。在验证组中，HBcrAg水平与IH-cccDNA水平之间存在显着相关性（P = 0.0012，r = 0.38），而FBS-cres评分与IH-cccDNA水平关系更密切（P <0.0001，r = 0.51）。在所有亚组分析中观察到类似的趋势。
结论：

我们提出的预测IH-cccDNA水平的模型可能对CHB患者有帮助。

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关键词：

慢性乙型肝炎;乙型肝炎核心相关抗原;乙型肝炎表面抗原;肝内共价闭合环状DNA;预测模型

结论：
    30358027
DOI：
    10.1111 / hepr.13280