AASLD2018[552]血清Hbcrag在慢性乙型肝炎中的表现 患有8年核的乙

StephenW

552
Performance of Serum Hbcrag in Chronic
Hepatitis B Patients with 8-Year Nucleos(t)Ide
Analogs Therapy
Meng-Lan Wang1, Enqiang Chen1, Juan Liao1, Juan Wang1
and Hong Tang2, (1)Center of Infectious Diseases, West
China Hospital of Sichuan University, (2)West China Hospital
of Sichuan University
Background: This study aimed to investigate long-term
kinetics of serum hepatitis B core-related antigen (HBcrAg) and
its correlation with serum hepatitis B surface antigen(HBsAg)
in a real-world cohort of patients who had received over 8
years of nucleos(t)ide analogs(NAs) therapy. Methods: This
was a retrospective study. All patients were recruited from
our previous published study, who started therapy with NAs
between 2007 and 2008. Serum HBcrAg and HBsAg levels
were quantitatively measured at baseline, the sixth month
and each year of follow-up, using the stored serum samples.
Results: Among the 94 patients, serum HBcrAg presented
a gradually decreasing trend from baseline to year 8, either
in HBeAg-negative or HBeAg-positive patients(Figure).
After 8 years of NAs treatment, 21.3% of patients achieved
serum HBcrAg<3 log 10 U/mL, and only baseline HBcrAg
was an independent predictor. Additionally, good correlation
of HBcrAg and HBsAg was observed at baseline, but
this correlation weakened remarkably during treatment.
Conclusion: Serum HBcrAg is decreasing gradually with the
duration of antiviral therapy, and baseline HBcrAg level is an
independent predictor of long-term HBcrAg below the limit of
detection.

StephenW

552
血清Hbcrag在慢性乙型肝炎中的表现
患有8年核的乙型肝炎患者（t）Ide
类比疗法
王梦兰1，陈恩强1，廖娟1，王娟1
和Hong Tang2，（1）西部传染病研究中心
四川大学中国医院，（2）华西医院
四川大学
背景：本研究旨在长期研究
血清乙型肝炎核心相关抗原（HBcrAg）和血清的动力学研究
与血清乙型肝炎表面抗原（HBsAg）的相关性
在收到8岁以上的现实世界的患者队列中
多年的核苷（酸）类似物（NAs）疗法。方法：这个
是一项回顾性研究。所有患者均来自
我们之前发表的研究，开始用NA治疗
2007年至2008年间。血清HBcrAg和HBsAg水平
在基线，第六个月定量测量
和每年的随访，使用储存的血清样本。
结果：94例患者中出现血清HBcrAg
从基线到第8年逐渐下降的趋势
在HBeAg阴性或HBeAg阳性患者中（图）。
经过8年的NAs治疗，21.3％的患者获得了治疗
血清HBcrAg <3 log 10 U / mL，仅有基线HBcrAg
是一个独立的预测者。另外，良好的相关性
在基线时观察到HBcrAg和HBsAg，但是
这种相关性在治疗期间显着减弱。
结论：血清HBcrAg逐渐下降
抗病毒治疗的持续时间和基线HBcrAg水平是一个
长期HBcrAg低于限值的独立预测因子
检测。