云南省新生儿乙型肝炎疫苗接种失败相关危险因素调查。

StephenW

Int J Infect Dis. 2018 Oct 5. pii: S1201-9712(18)34545-4. doi: 10.1016/j.ijid.2018.09.026. [Epub ahead of print]
Investigation of the risk factors associated with the failure of hepatitis B vaccination of neonates in Yunnan province, China.
Wang F1, Kang W2, Zhou W1, Su Q1, Bi S1, Qiu F3, Li Q4.
Author information

1
    Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention,Changping District, Beijing 102206, PR China.
2
    Center for Disease Control and Prevention of Yunnan Province, Kunming 650022, PR China.
3
    Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention,Changping District, Beijing 102206, PR China. Electronic address: [email protected].
4
    Center for Disease Control and Prevention of Yunnan Province, Kunming 650022, PR China. Electronic address: [email protected].

Abstract
OBJECTIVE:

This study aimed to investigate HBsAg positive rates and risk factors of HBV infection among the children less than 15 years old in Yunnan province, remote southwest part of China mainland.
METHODS:

Multi-stage sampling was used to randomly select study subjects from 9360000 individuals. Hepatitis B vaccine inoculation rate and HBsAg positive rate were investigated, and then propensity score and generalized linear mixed model (GLMMs) were applied to the case-control study.
RESULTS:

The average HBsAg positive rate was 1.81%, with 1.2% in urban areas and 2.4% in rural areas. Rate of first-dose-in-time in urban areas was 77.7%, obviously higher than 49.5% in rural areas (χ2=2811.71，P＜0.01). Similarly, 3-dose completion coverage rate in urban areas was 93.7%, also higher than 79.0% in rural areas (χ2=1561.43，P＜0.01). Maternal HBeAg positivity and HBsAg positivity were proved to be the main risk factors of children HBV infection. Moreover, paternal HBeAg positivity, paternal HBsAg positivity, the absence and unknown of HBV vaccine inoculation were risk factors of children HBV infection as well.
CONCLUSION:

It was very important to improve the HBV vaccine inoculation rates. Delivering babies in hospital and inoculating HBV vaccine timely were the efficient way to prevent HBV vertical transmission.

Copyright © 2018. Published by Elsevier Ltd.
KEYWORDS:

Generalized linear mixed model; Hepatitis B vaccines; Immune failure; Propensity score; Risk factors

PMID:
    30296573
DOI:
    10.1016/j.ijid.2018.09.02

StephenW

Int J Infect Dis。 2018年10月5日.pii：S1201-9712（18）34545-4。 doi：10.1016 / j.ijid.2018.09.026。 [提前打印]
云南省新生儿乙型肝炎疫苗接种失败相关危险因素调查。
Wang F1，Kang W2，Zhou W1，Su Q1，Bi S1，Qiu F3，Li Q4。
作者信息

1
    中国疾病预防控制中心病毒病预防控制所，北京市昌平区102206
2
    云南省疾病预防控制中心，昆明650022
3
    中国疾病预防控制中心病毒病预防控制所，北京市昌平区102206电子地址：[email protected]。
4
    云南省疾病预防控制中心，昆明650022电子地址：[email protected]。

抽象
目的：

本研究旨在调查中国大陆偏远西南部云南省15岁以下儿童HBs感染的HBsAg阳性率和危险因素。
方法：

使用多阶段取样从9360000个个体中随机选择研究对象。研究乙型肝炎疫苗接种率和HBsAg阳性率，然后将倾向评分和广义线性混合模型（GLMMs）应用于病例对照研究。
结果：

HBsAg平均阳性率为1.81％，城市地区为1.2％，农村地区为2.4％。城市地区首次服药率为77.7％，明显高于农村地区的49.5％（χ2= 2811.71，P <0.01）。同样，城市地区3剂量完成覆盖率为93.7％，也高于农村地区的79.0％（χ2= 1561.43，P <0.01）。母体HBeAg阳性和HBsAg阳性被证实是儿童HBV感染的主要危险因素。此外，父亲HBeAg阳性，父亲HBsAg阳性，HBV疫苗接种的缺失和未知也是儿童HBV感染的危险因素。
结论：

提高HBV疫苗接种率非常重要。在医院接送婴儿并及时接种HBV疫苗是预防HBV垂直传播的有效方法。

版权所有©2018。由Elsevier Ltd.出版
关键词：

广义线性混合模型;乙型肝炎疫苗;免疫失败;倾向得分;风险因素

结论：
    30296573
DOI：
    10.1016 / j.ijid.2018.09.02