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Saudi Med J. 2018 Oct;39(10):999-1005. doi: 10.15537/smj.2018.10.23056.
Assessment of histopathological alterations in patients with chronic hepatitis B infection following long-term oral antiviral therapy.
Şahin A1, Namıduru M, Balkan A, Karaoğlan İ, Gülşen MT.
Author information
1
Department of Infectious Diseases and Clinical Microbiology, Çankırı State Hospital, Çankırı, Turkey. E-mail:. [email protected].
Abstract
OBJECTIVES:
To evaluate the histopathological changes in the liver after oral antiviral therapy in patients with chronic hepatitis B.
METHODS:
A total of 79 HBeAg-negative and positive patients who had been on lamivudine, entecavir, or tenofovir disoproxil for at least 3 years prior to inclusion were enrolled between March 2015 and 2016, retrospectively. There were 23 patients on lamivudine, 21 patients on entecavir, and 35 on tenofovir. All patients underwent a follow-up liver biopsy. Biochemical, serological, virological and histopathological data were recorded in all patients and were compared after at least 3 years of treatment with oral antiviral agents. Results: Histological activity index scores were reduced in patients who received lamivudine (p=0.011), entecavir (p=0.002), and tenofovir (p=0.001). Also, in contrast with a significant improvement in fibrosis scores in lamivudine (p=0.033) and tenofovir (p=0.001) groups no improvements were found in patients who received entecavir (p=0.090). Conclusion: Long term treatment with oral antiviral agents was associated with biochemical, virological, serological, and histopathological improvements. Long-term use of anti-viral agents as well as continuous suppression of HBV DNA are prerequisites for histopathological improvement.
PMID:
30284582
DOI:
10.15537/smj.2018.10.23056 |
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发表于 2018-10-7 14:14
