怀孕期间乙型肝炎疫苗接种安全

StephenW

Hannah Dellabella
October 05, 2018
Hepatitis B Vaccination Safe During Pregnancy
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No associations were found between hepatitis vaccination exposure during pregnancy and gestational hypertension, pre-eclampsia, cesarean delivery, or pre-term delivery. No associations were found between hepatitis vaccination exposure during pregnancy and gestational hypertension, pre-eclampsia, cesarean delivery, or pre-term delivery.

Most women who receive the hepatitis B vaccine (HepB) during pregnancy do not have an increased risk for adverse events, according to study results published in Vaccine.

Currently, many women who receive HepB during pregnancy are not at high risk for contracting hepatitis B virus (HBV).

The study included a retrospective cohort of pregnancies from the Vaccine Safety Datalink (VSD) that resulted in live births from 2004 through 2015. Pregnancies in women age 12 to 55 who were continuously enrolled in VSD-integrated healthcare systems from 6 months pre-pregnancy to 6 weeks postpartum were included (n=650,000).


The researchers compared pregnancies with HepB exposure with both pregnancies with other vaccine exposure and pregnancies with no vaccine exposure. They used ICD-9 codes to identify high-risk conditions for contracting HBV infection. In addition, maternal and fetal adverse events were evaluated based on HepB exposure status.

In the study cohort, HepB was administered at a rate of 2.1 pregnancies per 1000 (n=1399). Often, it was administered within the first 5 weeks of pregnancy.

In the HepB-exposed group, <3% had a high-risk ICD-9 code that indicated a need for HepB, with a similar rate in the HepB-unexposed groups.

The researchers did not find any significant associations between HepB exposure during pregnancy and gestational hypertension, gestational diabetes, pre-eclampsia/eclampsia, cesarean delivery, pre-term delivery, low birthweight, or small for gestational age infants.


“Regardless of the vaccination intent, our findings are consistent with those of previously published studies and provide added reassurance that it is safe to administer HepB to pregnant women both with and without high-risk indications for vaccination,” the researchers wrote.
Reference

Groom HC, Irving SA, Koppolu P, et al. Uptake and safety of hepatitis B vaccination during pregnancy: a Vaccine Safety Datalink study. Vaccine. 2018;36(41):6111-6116.

StephenW

汉娜德拉贝拉
2018年10月5日
怀孕期间乙型肝炎疫苗接种安全
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妊娠期肝炎疫苗接种与妊娠期高血压，先兆子痫，剖宫产或早产之间未发现相关性。妊娠期肝炎疫苗接种与妊娠期高血压，先兆子痫，剖宫产或早产之间未发现相关性。

根据Vaccine发表的研究结果，大多数在怀孕期间接种乙型肝炎疫苗（HepB）的女性不会增加不良事件的风险。

目前，许多在怀孕期间接受HepB治疗的女性患乙型肝炎病毒（HBV）的风险并不高。

该研究包括一项来自疫苗安全数据链（VSD）的妊娠回顾性队列，该妊娠安全数据链在2004年至2015年期间产生了活产.12至55岁的女性怀孕从怀孕前6个月开始连续参加VSD综合医疗系统产后6周（n = 650,000）。


研究人员将怀孕与接触HepB的孕妇与其他接种疫苗和未接种疫苗的怀孕进行了比较。他们使用ICD-9代码识别感染HBV感染的高风险条件。此外，基于HepB暴露状态评估母体和胎儿不良事件。

在研究队列中，HepB以每1000次妊娠2.1次（n = 1399）的比率给药。通常，它是在怀孕的前5周内给药。

在暴露于HepB的组中，<3％具有高风险的ICD-9代码，其表明需要HepB，在未暴露的HepB组中具有相似的比率。

研究人员未发现妊娠期间接触HepB与妊娠期高血压，妊娠期糖尿病，先兆子痫/子痫，剖腹产，早产，低出生体重或小于胎龄儿的婴儿之间有任何显着关联。


研究人员写道：“无论疫苗接种意图如何，我们的研究结果与之前发表的研究结果一致，并提供了额外的保证，即对有和没有高风险接种疫苗的孕妇使用HepB是安全的。”
参考

Groom HC，Irving SA，Koppolu P，et al。怀孕期间乙型肝炎疫苗接种的摄取和安全性：疫苗安全数据链研究。疫苗。 2018; 36（41）：6111-6116。