台湾南部慢性病毒性肝炎与代谢综合征的关联：一项基于人

StephenW

Aliment Pharmacol Ther. 2018 Sep 11. doi: 10.1111/apt.14960. [Epub ahead of print]
Association between chronic viral hepatitis and metabolic syndrome in southern Taiwan: a large population-based study.
Kuo YH1,2, Kee KM1, Wang JH1, Hsu NT1,3, Hsiao CC2,4, Chen Y5, Lu SN1,2,6.
Author information

1
    Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
2
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
3
    Biostatistics and Bioinformatics Center of Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
4
    Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
5
    Public Health Bureau, Tainan City Government, Tainan, Taiwan.
6
    Division of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.

Abstract
BACKGROUND:

The impact of metabolic syndrome (MetS) on hepatitis is an interesting issue.
AIM:

To evaluate the association of MetS and chronic viral hepatitis including hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in southern Taiwan.
METHODS:

From 2004 to 2013, a series of community-based health screenings for residents aged 40 and older were held in Tainan city. MetS was defined according to the Joint Scientific Statement. Cut-offs of body-mass index measures of 24 kg/m2 and 27 kg/m2 were used to stratify lean, overweight and obese subjects.
RESULTS:

We enrolled 180 359 participants; the prevalence of MetS was 30.1%, which was significantly associated with advanced age and female sex. There were 18 726 (10.4%) HBV, 13 428 (7.4%) HCV, 1337 (0.7%) HBV plus HCV (B+C) and 146 868 (81.5%) non-HBV non-HCV participants (NBNC). Prevalence rates of MetS in subjects with HBV, HCV, B+C and NBNC were 25.2%, 31.5%, 28.9% and 30.7% respectively (P < 0.001). There were 18.8% lean body, 35.4% overweight and 45.8% obese participants among 54 361 MetS subjects. Lean MetS subjects were older, had more diabetes, and had higher metabolic component levels, but lower alanine transaminase and aspartate transaminase-platelet ratio index levels compared with obese MetS subjects. HCV infection was positively associated with MetS (P < 0.001). However, HBV infection was inversely associated with MetS only among lean subjects (P = 0.002), but not among the general population.
CONCLUSIONS:

This large population-based study indicated that HCV infection was positively associated with MetS. However, HBV infection was inversely associated with MetS only among lean subjects.

© 2018 John Wiley & Sons Ltd.
KEYWORDS:

body mass index; community study; hepatitis B virus; hepatitis C virus; metabolic syndrome

PMID:
    30277595
DOI:
    10.1111/apt.14960

StephenW

Aliment Pharmacol Ther。 2018年9月11日doi：10.1111 / apt.14960。 [提前打印]
台湾南部慢性病毒性肝炎与代谢综合征的关联：一项基于人群的大型研究。
Ku YH1,2，Kee KM1，Wang JH1，Hsu NT1,3，Hsiao CC2,4，Chen Y5，Lu SN1,2,6。
作者信息

1
    台湾高雄市高雄长庚纪念医院和长庚大学医学院内科，肝内科，肝内科。
2
    台湾桃园长庚大学医学院临床医学研究所
3
    台湾高雄市高雄长庚纪念医院生物统计学和生物信息中心。
4
    台湾高雄市高雄长庚纪念医院冲击波医学与组织工程中心
五
    台南市台南市政府卫生局。
6
    台湾嘉义嘉义长庚纪念医院内科，肝内科

抽象
背景：

代谢综合征（MetS）对肝炎的影响是一个有趣的问题。
目标：

评估台湾南部MetS与慢性病毒性肝炎的关系，包括乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染。
方法：

从2004年到2013年，为台南市举办了一系列针对40岁及以上居民的社区健康检查。 MetS是根据联合科学声明定义的。使用24 kg / m2和27 kg / m2的体重指数测量值的截止值来对瘦，超重和肥胖受试者进行分层。
结果：

我们招收了180 359名参与者; MetS的患病率为30.1％，与高龄和女性性别显着相关。 HBV中有18 726（10.4％），HCV，13 428（7.4％），HBV + HCV（B + C）1337（0.7％）和非HBV非HCV参与者（NBNC）146 868（81.5％）。 HBV，HCV，B + C和NBNC患者的MetS患病率分别为25.2％，31.5％，28.9％和30.7％（P <0.001）。在54 361名MetS受试者中，瘦体率为18.8％，超重体重为35.4％，肥胖者为45.8％。与肥胖的MetS受试者相比，精益MetS受试者年龄更大，糖尿病更多，并且具有更高的代谢组分水平，但丙氨酸转氨酶和天冬氨酸转氨酶 - 血小板比率指数水平更低。 HCV感染与MetS呈正相关（P <0.001）。然而，仅在精益受试者中，HBV感染与MetS呈负相关（P = 0.002），而在一般人群中则不然。
结论：

这项大规模的人群研究表明，HCV感染与MetS呈正相关。然而，HBV感染仅与精益受试者中的MetS呈负相关。

©2018 John Wiley＆Sons Ltd.
关键词：

体重指数;社区学习;乙型肝炎病毒;丙型肝炎病毒;代谢综合征

结论：
    30277595
DOI：
    10.1111 / apt.14960