在接受替诺福韦地索普西富马酸盐预防乙型肝炎病毒母婴传

StephenW

Antimicrob Agents Chemother. 2018 Oct 1. pii: AAC.01686-18. doi: 10.1128/AAC.01686-18. [Epub ahead of print]
Tenofovir exposure during pregnancy and postpartum in women receiving tenofovir disoproxil fumarate for the prevention of mother-to-child transmission of hepatitis B virus.
Cressey TR1,2,3, Harrison L4, Achalapong J5, Kanjanavikai P6, Patamasingh Na Ayudhaya O7, Liampongsabuddhi P8, Siriwachirachai T9, Putiyanun C10, Suriyachai P11, Tierney C4, Salvadori N12, Chinwong D13, Decker L14, Tawon Y12, Murphy TV15, Ngo-Giang-Huong N12,2,14, Siberry GK16, Jourdain G12,2,13; iTAP study team.
Author information

1
    PHPT/IRD, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand [email protected].
2
    Department of Immunology & Infectious Diseases, Boston, Harvard T.H Chan School of Public Health, MA, USA.
3
    Department of Molecular & Clinical Pharmacology, University of Liverpool, UK.
4
    Center for Biostatistics in AIDS Research (CBAR), Harvard T.H. Chan School of Public Health, USA.
5
    Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand.
6
    Banglamung Hospital, Chonburi, Thailand.
7
    Nopparat Rajathanee Hospital, Bangkok, Thailand.
8
    Lampang Hospital, Lampang, Thailand.
9
    Khon Kaen Hospital, Khon Kaen, Thailand.
10
    Chiang Kham Hospital, Phayao, Thailand.
11
    Phayao Provincial Hospital, Phayao, Thailand.
12
    PHPT/IRD, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
13
    Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Thailand.
14
    Institut de Recherche pour le Développement (IRD), Unité Mixte Internationale 174-PHPT, Chiang Mai, Thailand.
15
    Centers for Disease Control and Prevention, Atlanta, USA.
16
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Abstract

We assessed tenofovir exposure during pregnancy and postpartum in hepatitis B virus (HBV)-infected, HIV-uninfected, women receiving tenofovir disoproxil fumarate (TDF) to prevent mother-to-child transmission of HBV. Data from 154 women who received TDF within a randomized-controlled trial were included. Individual plasma tenofovir exposures (AUC0-24) were estimated using a population pharmacokinetic approach. Estimated geometric mean tenofovir AUC0-24 was 20% (95% CI: 19-21%) lower during pregnancy compared to postpartum; this modest reduction in the absence of HBV transmission suggests no dose adjustment is needed.

PMID:
    30275094
DOI:
    10.1128/AAC.01686-18

StephenW

抗微生物剂Chemother。 2018年10月1日.pii：AAC.01686-18。 doi：10.1128 / AAC.01686-18。 [提前打印]
在接受替诺福韦地索普西富马酸盐预防乙型肝炎病毒母婴传播的妇女怀孕和产后接触替诺福韦。
Cressey TR1,2,3，Harrison L4，Achalapong J5，Kanjanavikai P6，Patamasingh Na Ayudhaya O7，Liampongsabuddhi P8，Siriwachirachai T9，Putiyanun C10，Suriyachai P11，Tierney C4，Salvadori N12，Chinwong D13，Decker L14，Tawon Y12，Murphy TV15 ，Ngo-Giang-Huong N12,2,14，Siberry GK16，Jourdain G12,2,13; iTAP学习团队。
作者信息

1
    PHPT / IRD，泰国清迈，清迈大学医学院医学技术系，[email protected]。
2
    波士顿免疫学与传染病系，哈佛T.H陈公共卫生学院，美国马萨诸塞州。
3
    英国利物浦大学分子与临床药理学系。
4
    艾滋病研究中心生物统计学中心（CBAR），哈佛T.H.陈美国公共卫生学院。
五
    Chiangrai Prachanukroh医院，清莱，泰国。
6
    Banglamung医院，春武里市，泰国。
7
    Nopparat Rajathanee医院，曼谷，泰国。
8
    Lampang医院，Lampang，泰国。
9
    Khon Kaen医院，Khon Kaen，泰国。
10
    Chiang Kham医院，Phayao，泰国。
11
    Phayao省立医院，Phayao，泰国。
12
    PHPT / IRD，泰国清迈清迈大学医学技术系，相关医学科学院。
13
    泰国清迈大学药学院药学服务系。
14
    Institut de Recherche pourleDéveloppement（IRD），UnitéMixteInternationale 174-PHPT，Chiang Mai，Thailand。
15
    美国亚特兰大疾病预防控制中心。
16
    Eunice Kennedy Shriver国立儿童健康与人类发展研究所，美国国立卫生研究院，贝塞斯达，美国。

抽象

我们评估了妊娠期和产后期间接受替诺福韦暴露的乙型肝炎病毒（HBV）感染，未感染艾滋病毒的妇女，接受替诺福韦地索普西富马酸盐（TDF）以预防母婴传播HBV。收集了154名在随机对照试验中接受TDF的女性的数据。使用群体药代动力学方法估计个体血浆替诺福韦暴露（AUC0-24）。与产后相比，怀孕期间估计的几何平均替诺福韦AUC0-24为20％（95％CI：19-21％）;在没有HBV传播的情况下适度减少表明不需要调整剂量。

结论：
    30275094
DOI：
    10.1128 / AAC.01686-18