白细胞介素-21重新激活乙型肝炎病毒（HBV）特异性CD8 + T细胞

StephenW

J Infect Dis. 2018 Sep 27. doi: 10.1093/infdis/jiy576. [Epub ahead of print]
Interleukin-21 Reinvigorates the Antiviral Activity of Hepatitis B Virus (HBV)-Specific CD8+ T Cells in Chronic HBV Infection.
Tang L1, Chen C1, Gao X1,2, Zhang W1, Yan X1,3, Zhou Y1, Guo L1, Zheng X1, Wang W1, Yang F4, Liu G4, Sun J1, Hou J1, Li Y1.
Author information

1
    State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China.
2
    Department of Hepatology, Huizhou Municipal Central Hospital, Huizhou, China.
3
    Department of Infectious Diseases and Hepatology Unit, Huadu District People's Hospital of Guangzhou, Guangzhou, China.
4
    Liver Disease Research Center, the 458th Hospital of the Chinese People's Liberation Army, Guangzhou, China.

Abstract
Background:

Strategies that target functional recovery of exhausted hepatitis B virus (HBV)-specific CD8 + T cells are beneficial for viral control, but the potential for interleukin (IL)-21 to rescue CD8 + T cell function is not well understood.
Methods:

We investigated the effect of IL-21 on CD8+ T cell responses by phenotypic and functional analysis of samples from patients with chronic HBV infection and mouse model with HBV expression.
Results:

IL-21 promoted the proliferative capacity of HBV-specific CD8+ T cells and downregulated expression of inhibitory receptors programmed death-1 and T cell immunoglobulin domain and mucin domain 3. Additionally, IL-21 boosted the production of interferon-γ, granzyme B, and CD107a in HBV-specific CD8+ T cells and enhanced the cytolytic activity of CD8+ T cells against HepG2.2.15 cells. Notably, an HBV mouse model established from IL-21 receptor knockout mice showed significantly decreased frequency of HBV-specific CD8+ T cells and increased levels of serum HBsAg. Meanwhile, administration of recombinant mouse IL-21 in an HBV mouse model established from wild-type mice resulted in enhanced functionality of HBV-specific CD8+ T cells and accelerated HBsAg clearance.
Conclusions:

IL-21 enhances the antiviral effect of HBV-specific CD8+ T cells, suggesting that it may contribute to viral clearance in chronic HBV infection.

PMID:
    30260401
DOI:
    10.1093/infdis/jiy576

StephenW

J Infect Dis。 2018年9月27日doi：10.1093 / infdis / jiy576。 [提前打印]
白细胞介素-21重新激活乙型肝炎病毒（HBV）特异性CD8 + T细胞在慢性HBV感染中的抗病毒活性。
Tang L1，Chen C1，Gao X1,2，Zhang W1，​​Yan X1,3，Zhou Y1，Guo L1，Zheng X1，Wang W1，​​Yang F4，Liu G4，Sun J1，Hou J1，Li Y1。
作者信息

1
    南方医科大学南方医院传染病与肝病科，广东省病毒性肝炎研究重点实验室器官衰竭研究国家重点实验室，广州
2
    惠州市中心医院肝病科，惠州
3
    广州市花都区人民医院传染病与肝病科，广州
4
    中国人民解放军第458医院肝病研究中心，广州，中国。

抽象
背景：

针对功能恢复的乙型肝炎病毒（HBV）特异性CD8 + T细胞的策略有利于病毒控制，但白细胞介素（IL）-21拯救CD8 + T细胞功能的潜力尚不清楚。
方法：

我们通过慢性HBV感染患者和HBV表达小鼠模型的表型和功能分析研究了IL-21对CD8 + T细胞应答的影响。
结果：

IL-21促进HBV特异性CD8 + T细胞的增殖能力，并下调抑制性受体程序的死亡-1和T细胞免疫球蛋白结构域和粘蛋白结构域3的表达。另外，IL-21促进干扰素-γ，颗粒酶B的产生，和CD107a在HBV特异性CD8 + T细胞中增强CD8 + T细胞对HepG2.2.15细胞的细胞溶解活性。值得注意的是，从IL-21受体敲除小鼠建立的HBV小鼠模型显示HBV特异性CD8 + T细胞的频率显着降低和血清HBsAg水平升高。同时，在由野生型小鼠建立的HBV小鼠模型中施用重组小鼠IL-21导致HBV特异性CD8 + T细胞的功能增强和HBsAg清除加速。
结论：

IL-21增强HBV特异性CD8 + T细胞的抗病毒作用，表明它可能有助于慢性HBV感染中的病毒清除。

结论：
    30260401
DOI：
    10.1093 / infdis / jiy576

齐欢畅

Hepbest

T细胞是一个好东西，未来针对任何病，只要抽出血液，分离T细胞。
根据人体的病，进行安装这种病的特异性CDx，然后回输到病人体内。
就可以带动人体免疫清除特定的病毒损伤，达到修复的目的。

人体衰老，也是由于细胞更新速度低于死亡速度。这个技术不能说让人类不死，但是可以让寿命延长

齐欢畅

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