糖尿病是中国慢性乙型肝炎病毒感染患者肝细胞癌的危险因

StephenW

Med Sci Monit. 2018 Sep 24;24:6729-6734. doi: 10.12659/MSM.911702.
Diabetes Mellitus is a Risk Factor for Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Virus Infection in China.
Li X1, Xu H1,2, Gao P1.
Author information

1
    Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun, Jilin, China (mainland).
2
    Jilin Province Key Laboratory of Infectious Disease, Laboratory of Molecular Virology, Changchun, Jilin, China (mainland).

Abstract

BACKGROUND This study aimed to investigate whether diabetes mellitus (DM) increased the risk of developing hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection. MATERIAL AND METHODS Individuals with a confirmed diagnosis of HCC and chronic HBV infection (n=112), and non-diabetic individuals with both chronic HBV infection and HCC (n=210), were matched by age, sex, and degree of liver cirrhosis. Demographic, lifestyle, and clinical data were reviewed. Data were analyzed by univariate and multiple logistic regression analysis to identify the risk factors for HCC. RESULTS Of the 112 patients with HCC (median age, 52.0 years; range, 46.3-56.0 years), 18.8% were men, and the prevalence of cirrhosis was 90.2%. Of the 210 patients without HCC (median age, 51.0 years; range, 47.0-58.0 years), 26.2% were men, and the prevalence of cirrhosis was 91.9%. Diabetes mellitus was more prevalent among individuals with HCC (16.1%) compared with those without HCC (7.6%) and increased the risk for HCC by two-fold to three-fold (adjusted odds ratio [AOR]: 2.402; 95% confidence interval [CI], 1.150-5.018). Multivariate analysis showed that cigarette smoking significantly increased the risk of HBV-related HCC (AOR: 1.665; 95% CI, 1.031-2.690), as did increased levels of HBV DNA (≥10³ IU/mL) (AOR: 1.753; 95% CI, 1.079-2.849). CONCLUSIONS In a Chinese population with chronic HBV infection, DM increased the risk of HCC, as did cigarette smoking and high levels of HBV DNA. Screening patients with known risk factors for HCC might improve early detection rates and treatment to prevent tumor progression.

PMID:
    30245503
DOI:
    10.12659/MSM.911702

StephenW

Med Sci Monit。 2018年9月24日; 24：6729-6734。 doi：10.12659 / MSM.911702。
糖尿病是中国慢性乙型肝炎病毒感染患者肝细胞癌的危险因素。
李X1，徐H1,2，高P1。
作者信息

1
    吉林大学第一医院肝病科，吉林长春，吉林，中国（大陆）。
2
    吉林省传染病重点实验室，分子病毒学实验室，吉林长春，大陆。

抽象

背景本研究旨在探讨糖尿病（DM）是否会增加慢性乙型肝炎病毒（HBV）感染患者发生肝细胞癌（HCC）的风险。材料与方法确诊为HCC和慢性HBV感染的个体（n = 112），以及同时患有慢性HBV感染和HCC（n = 210）的非糖尿病患者，均与年龄，性别和肝硬化程度相匹配。对人口统计学，生活方式和临床数据进行了审查。通过单变量和多重逻辑回归分析来分析数据以鉴定HCC的风险因子。结果112例HCC患者（中位年龄52.0岁;范围46.3-56.0岁），男性占18.8％，肝硬化患病率为90.2％。 210例无HCC患者（中位年龄51.0岁;范围47.0-58.0岁）中，男性占26.2％，肝硬化患病率为91.9％。与没有HCC的患者（7.6％）相比，HCC患者中糖尿病更为普遍（16.1％），并且HCC风险增加2倍至3倍（调整后的比值比[AOR]：2.402; 95％置信区间） [CI]，1.150-5.018）。多变量分析显示，吸烟显着增加了HBV相关HCC的风险（AOR：1.665; 95％CI，1.031-2.690），HBV DNA水平增加（≥10³IU/ mL）（AOR：1.753; 95％） CI，1.079-2.849）。结论在中国慢性HBV感染人群中，DM增加了患HCC的风险，吸烟和高水平的HBV DNA也是如此。筛查已知HCC危险因素的患者可能会提高早期检出率和治疗以预防肿瘤进展。

结论：
    30245503
DOI：
    10.12659 / MSM.911702