抗病毒治疗有效地改善了肝脏血流动力学，血清生物标志物

StephenW

PeerJ. 2018 Sep 12;6:e5484. doi: 10.7717/peerj.5484. eCollection 2018.
Antiviral therapy effectively improves liver hemodynamics as evidenced by serum biomarker and contrast-enhanced ultrasound examinations in patients with hepatitis B cirrhosis.
Xu X1, Zhang C2, Shi C1, Hu N1, Sun B1, Kong D1, Xu J1.
Author information

1
    Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
2
    Department of Ultrasound, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Abstract
Background and Aims:

To prospectively evaluate the effects of antiviral therapy on liver hemodynamics in patients with hepatitis B cirrhosis.
Methods:

Seventy consecutive eligible HBV-related cirrhotic inpatients were enrolled in the prospective study. Fifty-two received different nucleoside analogs monotherapy and 18 denied antiviral therapy. Their liver biochemistry profiles and HBV-DNA were measured at the baseline and every 3 months. Peripheral blood vWF and sCD163, as well as liver ultrasound Doppler parameters including portal vein diameter (PVD), portal vein velocity (PVV), portal vein congestion index (PV-CI), hepatic vein damping index (HV-DI), hepatic arterial arrival time (HAAT), hepatic vein arrival time (HVAT) and intrahepatic cycle time (HV-HA), were measured at the baseline and the follow-up periods.
Results:

In the antiviral group, all patients achieved complete virologic and liver biochemical responses after 3-month antiviral treatment. Furthermore, the response states were maintained till the follow-up endpoint. However, in the non-antiviral group, HBV DNA replication resulted in higher levels of ALT and AST compared to the baseline values (P < 0.05). In the antiviral group, PVD, PV-CI, HV-DI, vWF-Ag and sCD163 were all significantly reduced than the baseline values (P < 0.05), and PVV was significantly increased than the baseline value (P < 0.05).
Conclusions:

Antiviral therapy could effectively suppress hepatocyte inflammation and alleviate the dysfunction of intrahepatic vascular endothelial and hepatic macrophages, which might improve hepatic hemodynamic function in HBV-related cirrhosis.
KEYWORDS:

Cirrhosis; Hepatitis B virus

PMID:
    30225162
PMCID:
    PMC6139013
DOI:
    10.7717/peerj.5484

StephenW

PeerJ。 2018年9月12日; 6：e5484。 doi：10.7717 / peerj.5484。 eCollection 2018。
抗病毒治疗有效地改善了肝脏血流动力学，血清生物标志物和对比增强超声检查证实了乙型肝炎肝硬化患者。
Xu X1，Zhang C2，Shi C1，Hu N1，Sun B1，Kong D1，Xu J1。
作者信息

1
    安徽医科大学第一附属医院消化内科，合肥
2
    安徽医科大学第一附属医院超声科，合肥，中国。

抽象
背景和目的：

前瞻性评估抗病毒治疗对乙型肝炎肝硬化患者肝脏血流动力学的影响。
方法：

70名符合条件的HBV相关肝硬化住院患者参加了前瞻性研究。 52个接受不同的核苷类似物单药治疗，18个拒绝接受抗病毒治疗。他们的肝脏生化特征和HBV-DNA在基线和每3个月测量一次。外周血vWF和sCD163，以及肝脏超声多普勒参数，包括门静脉直径（PVD），门静脉速度（PVV），门静脉阻塞指数（PV-CI），肝静脉阻滞指数（HV-DI），肝动脉在基线和随访期间测量到达时间（HAAT），肝静脉到达时间（HVAT）和肝内循环时间（HV-HA）。
结果：

在抗病毒组中，所有患者在3个月抗病毒治疗后均获得完整的病毒学和肝脏生化反应。此外，响应状态保持到后续终点。然而，在非抗病毒组中，与基线值相比，HBV DNA复制导致更高水平的ALT和AST（P <0.05）。在抗病毒组中，PVD，PV-CI，HV-DI，vWF-Ag和sCD163均显着低于基线值（P <0.05），PVV显着高于基线值（P <0.05）。
结论：

抗病毒治疗可有效抑制肝细胞炎症，减轻肝内血管内皮和肝巨噬细胞的功能障碍，从而改善HBV相关性肝硬化患者的肝血流动力学功能。
关键词：

肝硬化;乙型肝炎病毒

结论：
    30225162
PMCID：
    PMC6139013
DOI：
    10.7717 / peerj.5484

StephenW

https://peerj.com/articles/5484/