乙型肝炎的新病毒生物标志物：我们能改变做法吗？

StephenW

J Viral Hepat. 2018 Sep 5. doi: 10.1111/jvh.12993. [Epub ahead of print]
New viral biomarkers for Hepatitis B: Are we able to change practice?
Höner Zu Siederdissen C1, Maasoumy B1, Cornberg M1,2.
Author information

1
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
2
    German Center for Infection Research (DZIF), Partner Site Hannover, Braunschweig, Germany.

Abstract

The management of chronic hepatitis B virus (HBV) infection is challenged by its varying natural course and its stealthy nature. Not all HBV infected patients will develop complications of infection; however, it is of utmost importance to identify patients who are at risk and require antiviral treatment and/or close surveillance. Hepatic inflammation and quantification of HBV DNA have guided treatment decisions in the last decade and these guided interventions have been shown to reduce liver related complications and death. Data on the quantification of additional HBV markers such as hepatitis B surface antigen (HBsAg), hepatitis B core-related antigen (HBcrAg) and hepatitis B virus RNA (HBV RNA) have accumulated in recent years. Here we review the current evidence of how to use these markers and discuss open issues that require additional research. This article is protected by copyright. All rights reserved.
KEYWORDS:

HBV RNA ; HBV infection; HBcrAg; HBsAg; Nuleos(t)ide analogues; PEG-IFN

PMID:
    30187603
DOI:
    10.1111/jvh.12993

StephenW

J病毒肝病。 2018年9月5日：doi：10.1111 / jvh.12993。 [提前打印]
乙型肝炎的新病毒生物标志物：我们能改变做法吗？
HönerZuSiederdissen C1，Maasoumy B1，Cornberg M1,2。
作者信息

1
    汉诺威医学院消化内科，肝脏病学和内分泌科，Carl-Neuberg-Str。 1,30625，德国汉诺威。
2
    德国感染研究中心（DZIF），合作伙伴网站汉诺威，德国不伦瑞克。

抽象

慢性乙型肝炎病毒（HBV）感染的管理受到其不同的自然过程及其隐身性质的挑战。并非所有HBV感染的患者都会出现感染并发症;然而，识别处于危险中且需要抗病毒治疗和/或密切监视的患者至关重要。在过去十年中，肝脏炎症和HBV DNA的定量指导了治疗决策，这些指导干预措施已被证明可以减少肝脏相关的并发症和死亡。近年来积累了关于额外HBV标志物如乙型肝炎表面抗原（HBsAg），乙型肝炎核心相关抗原（HBcrAg）和乙型肝炎病毒RNA（HBV RNA）的定量数据。在这里，我们回顾了如何使用这些标记的当前证据，并讨论需要进一步研究的开放性问题。本文受版权保护。版权所有。
关键词：

HBV RNA; HBV感染; HBcrAg;乙肝表面抗原; Nuleos（t）ide类似物; PEG-IFN

结论：
    30187603
DOI：
    10.1111 / jvh.12993

newchinabok

又快过一年了，过了一年又一年，已经等白了头，心已冷，看这些文章已都麻木了