浆细胞样树突状细胞，自然杀伤细胞及其在HBV感染中的串扰

StephenW

Rev Med Virol. 2018 Sep 2:e2007. doi: 10.1002/rmv.2007. [Epub ahead of print]
Immune function of plasmacytoid dendritic cells, natural killer cells, and their crosstalk in HBV infection.
Golsaz-Shirazi F1, Amiri MM1, Shokri F1,2.
Author information

1
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
2
    Monoclonal Antibody Research Center, Avicenna Research Institute, Tehran, Iran.

Abstract

Chronic hepatitis B virus infection is a major health problem, with over 245 million chronic carriers worldwide. This persistent infection is thought to be associated with inefficient innate and adaptive immune responses. Natural killer cells (NK cells) and plasmacytoid dendritic cells (pDCs) are the major innate immune cells which respond to viral infection at the early phase and are considered major components of the antiviral immune response. In this review, we summarize recent findings regarding the role of NK cells, pDCs, and their cross-talk in HBV infection and its chronicity. Although the data regarding the biological function of pDCs and NK cells in HBV infection is still controversial, many studies show that in chronic HBV infection, the cytotoxicity of NK cells is retained, while their capacity to secrete cytokines is strongly impaired. In addition, interferon-α production by pDCs is impaired during chronic HBV infection, and the virus interferes with pDC-NK cell interaction.
KEYWORDS:

HBV infection; natural killer cells; plasmacytoid dendritic cells

PMID:
    30175481
DOI:
    10.1002/rmv.2007

StephenW

Rev Med Virol。 2018年9月2日：e2007。 doi：10.1002 / rmv.2007。 [提前打印]
浆细胞样树突状细胞，自然杀伤细胞及其在HBV感染中的串扰的免疫功能。
Golsaz-Shirazi F1，Amiri MM1，Shokri F1,2。
作者信息

1
    伊朗德黑兰德黑兰医科大学公共卫生学院免疫学系。
2
    单克隆抗体研究中心，伊维森纳研究所，伊朗德黑兰。

抽象

慢性乙型肝炎病毒感染是一个主要的健康问题，全世界有超过2.45亿的慢性携带者。这种持续性感染被认为与低效的先天性和适应性免疫应答有关。自然杀伤细胞（NK细胞）和浆细胞样树突细胞（pDC）是主要的先天免疫细胞，其在早期阶段响应病毒感染并且被认为是抗病毒免疫应答的主要组分。在这篇综述中，我们总结了有关NK细胞，pDC及其在HBV感染及其慢性中的交叉作用的最新发现。尽管关于pDCs和NK细胞在HBV感染中的生物学功能的数据仍然存在争议，但许多研究表明，在慢性HBV感染中，NK细胞的细胞毒性得以保留，而它们分泌细胞因子的能力受到严重损害。此外，在慢性HBV感染期间，pDC的干扰素-α产生受损，并且该病毒干扰pDC-NK细胞相互作用。
关键词：

HBV感染;自然杀伤细胞;浆细胞样树突状细胞

结论：
    30175481
DOI：
    10.1002 / rmv.2007