一种用于诊断肝细胞癌患者肝纤维化分期的新型非侵入性模

StephenW

A novel, non-invasive model for diagnosing liver fibrosis stage in patients with hepatocellular carcinoma

    Gao-Xiong Ouyang, Yu-mei Zhang, Shao-Liang Zhu, Peng Wang, Yuan Ren, Jia-Hao Li, Yu-Kai Liu, Jun Chen, Bang-De Xiang, Le-Qun Li, Jian-Yong Liu & Zhi-Ming Zhang

Scientific Reportsvolume 8, Article number: 13074 (2018) | Download Citation
Abstract

The aim of this study was to investigate the diagnostic value of the platelet count-to-spleen volume ratio (PSR) for diagnosing hepatic fibrosis in patients with hepatocellular carcinoma (HCC). In this interim analysis of an on-going prospective study, 117 patients with HCC and with or without cirrhosis or fibrosis in different stages were analyzed. Fibrosis staging negatively correlated with PSR and the liver volume-to-spleen volume ratio (LSR), while it positively correlated with aspartate aminotransferase-to-platelet ratio index (APRI), Frons’ index, S-index and a fibrosis index based on four factors (FIB-4). The area under the receiver operating characteristic curve (AUROC) was significantly larger for PSR (0.777) than LSR (0.633, P = 0.002). Among patients with significant fibrosis, AUROC for PSR did not differ significantly from the AUROCs for APRI (0.789, P = 0.825), Frons’ index (0.674, P = 0.102), FIB-4 (0.704, P = 0.251) or S-index (0.696, P = 0.204). Among patients with severe fibrosis, AUROC was significantly higher for PSR (0.808) than for LSR (0.685, P = 0.003), Frons’ index (0.673, P = 0.014), FIB-4 (0.684, P = 0.029), or S-index (0.672, P = 0.016); in contrast, the AUROC for PSR was not significantly different from that for APRI (0.739, P = 0.215). Among patients with cirrhosis, AUROC was significantly higher for PSR (0.814) than for LSR (0.671, P = 0.001) or S-index (0.679, P = 0.022), while the AUROC for PSR did not differ significantly from those for APRI (0.711, P = 0.105), Frons’ index (0.722, P = 0.061) or FIB-4 (0.708, P = 0.079). Our results suggest that PSR may be a useful non-invasive model for diagnosing liver fibrosis stage in patients with HCC in China.

StephenW

一种用于诊断肝细胞癌患者肝纤维化分期的新型非侵入性模型

    欧阳高雄，张玉梅，朱少良，王鹏，袁仁，李佳昊，刘玉凯，陈军，李邦德，李乐群，刘建勇 - 张明

Scientific Reportsvolume 8，货号：13074（2018）|下载引文
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本研究的目的是探讨血小板计数 - 脾脏体积比（PSR）对肝细胞癌（HCC）患者肝纤维化的诊断价值。在这项正在进行的前瞻性研究的中期分析中，分析了117例HCC患者和不同阶段的肝硬化或纤维化患者。纤维化分期与PSR和肝脏体积与脾脏体积比（LSR）呈负相关，而与天冬氨酸氨基转移酶与血小板比值指数（APRI），Frons指数，S指数和纤维化指数呈正相关。四个因素（FIB-4）。受试者工作特征曲线下面积（AUROC）PSR（0.777）明显大于LSR（0.633，P = 0.002）。在具有显着纤维化的患者中，PSR的AUROC与APRI的AUROC（0.789，P = 0.825），Frons'指数（0.674，P = 0.102），FIB-4（0.704，P = 0.251）或S-的AUROC没有显着差异。指数（0.696，P = 0.204）。在严重纤维化患者中，AUROC显着高于PSR（0.808），高于LSR（0.685，P = 0.003），Frons指数（0.673，P = 0.014），FIB-4（0.684，P = 0.029）或S -index（0.672，P = 0.016）;相比之下，PSR的AUROC与APRI的AUROC没有显着差异（0.739，P = 0.215）。在肝硬化患者中，AUROC的PSR（0.814）显着高于LSR（0.671，P = 0.001）或S指数（0.679，P = 0.022），而PSR的AUROC与APRI的AUROC无显着差异（ 0.711，P = 0.105），Frons指数（0.722，P = 0.061）或FIB-4（0.708，P = 0.079）。我们的研究结果表明，PSR可能是一种有用的非侵入性模型，可用于诊断中国HCC患者的肝纤维化分期。

StephenW

https://www.nature.com/articles/ ... Id=MTQ4MDQ0MTQwNAS2