乙型肝炎感染会增加患肾病的风险吗？

StephenW

Does hepatitis B infection increase the risk of kidney disease?
By
Cindi Hoover -
August 21, 2018

Researchers investigated the relationship between chronic hepatitis B infection and chronic kidney disease in half a million adults in China.

In 2010, over 10% of adults in China had chronic kidney disease. People diagnosed with this condition have kidney damage or have shown signs of decreased kidney function for at least three months. Diabetes, high blood pressure, age, obesity, smoking, and cardiovascular disease are all risk factors for chronic kidney disease. Hepatitis B infection is also known to negatively affect kidney function. In fact, a recent study reported that hepatitis B infection is linked to a higher risk of kidney disease.

Because China is a country where hepatitis B infection is relatively prevalent, a group of researchers studied hepatitis B infection data alongside data on chronic kidney disease and overall health with the hope of better preventing chronic kidney disease. Their work was recently published in BMC Medicine.

Using an existing health database from the China Kadoorie Biobank, researchers collected hepatitis B and chronic kidney disease data from almost half a million Chinese adults. Between 2004 and 2008, the Biobank collected health data from participants at the start of the study and continued to monitor their health until the end of 2015. This long-term health information allowed researchers to study chronic kidney disease in relation to hepatitis B status, socio-demographic factors (age, education level, marital status) and lifestyle behaviors (diet, smoking status, exercise level, alcohol consumption).

The vast majority (97%) of study participants did not have hepatitis B. However, after analyzing the data and adjusting for various health and lifestyle factors, the researchers found that chronic hepatitis B infection was linked to a 37% increased risk of chronic kidney disease. Additionally, the combination of hepatitis B infection with smoking, low levels of exercise, and diabetes led to a higher risk of chronic kidney disease.

Based on these results, the researchers recommend that people with chronic hepatitis B infection receive early chronic kidney disease screenings. Increasing physical activity, quitting smoking, and improving blood sugar control may also help prevent chronic kidney disease in people with hepatitis B.

Written by Cindi A. Hoover, Ph.D.

Reference: Si J, Yu C, Guo Y et al. Chronic hepatitis B virus infection and risk of chronic kidney disease: a population-based prospective cohort study of 0.5 million Chinese adults. 2018. BMC Medicine 16:93. https://doi.org/10.1186/s12916-018-1084-9

StephenW

乙型肝炎感染会增加患肾病的风险吗？
通过
Cindi Hoover -
2018年8月21日
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研究人员调查了中国50万成年人慢性乙型肝炎感染与慢性肾病之间的关系。

2010年，中国超过10％的成年人患有慢性肾病。被诊断患有这种疾病的人有肾脏损害或至少有三个月出现肾功能下降的迹象。糖尿病，高血压，年龄，肥胖，吸烟和心血管疾病都是慢性肾病的危险因素。还已知乙型肝炎感染会对肾功能产生负面影响。事实上，最近的一项研究报告说，乙型肝炎感染与肾脏疾病的高风险有关。

由于中国是乙型肝炎感染相对普遍的国家，一组研究人员研究了乙型肝炎感染数据以及慢性肾病和整体健康数据，希望能更好地预防慢性肾病。他们的工作最近发表在BMC Medicine上。

利用中国嘉道理生物银行现有的健康数据库，研究人员收集了近50万中国成年人的乙型肝炎和慢性肾病数据。在2004年至2008年期间，生物银行在研究开始时收集了参与者的健康数据，并继续监测其健康状况，直到2015年底。这一长期健康信息使研究人员能够研究与乙型肝炎状况有关的慢性肾病，社会人口因素（年龄，教育程度，婚姻状况）和生活方式行为（饮食，吸烟状况，运动水平，饮酒）。

绝大多数（97％）研究参与者没有乙型肝炎。然而，在分析数据并调整各种健康和生活方式因素后，研究人员发现慢性乙型肝炎感染与慢性肾病风险增加37％有关。疾病。此外，乙型肝炎感染与吸烟，低水平运动和糖尿病的结合导致慢性肾病的高风险。

基于这些结果，研究人员建议患有慢性乙型肝炎的人接受早期慢性肾病筛查。增加身体活动，戒烟和改善血糖控制也可能有助于预防乙型肝炎患者的慢性肾病。

作者：Cindi A. Hoover，博士。

参考文献：Si J，Yu C，Guo Y等。慢性乙型肝炎病毒感染和慢性肾病风险：一项针对50万中国成年人的人群前瞻性队列研究。 2018. BMC Medicine 16:93。 https://doi.org/10.1186/s12916-018-1084-9