适合中国成人免疫接种的乙型肝炎疫苗：系统评价和荟萃分

StephenW

Hum Vaccin Immunother. 2018 Aug 8. doi: 10.1080/21645515.2018.1509172. [Epub ahead of print]
Suitable hepatitis B vaccine for adult immunization in China: a systematic review and meta-analysis.
Wu Z1, Bao H1, Yao J2, Chen Y2, Lu S3, Li J4, Jiang ZG2, Ren JJ5, Xu KJ5, Ruan B5, Yang SG5, Xie TS5, Hu Y2.
Author information

1
    a School of Medicine , Ningbo University , Ningbo , Zhejiang , China.
2
    b The Office of the National Science and Technology Project , Zhejiang Provincial Centers for Disease Control and Prevention , Hangzhou , Zhejiang , China.
3
    c Medical record room , Ningbo Medical Center Lihuili Eastern Hospital , Ningbo , Zhejiang , China.
4
    d Medical record room , Zhejiang Provincial Hospital , Hangzhou , Zhejiang , China.
5
    e State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases, The First Affiliated Hospital, School of Medicine , Zhejiang University , Hangzhou , Zhejiang , China.

Abstract

Hepatitis B virus (HBV) infection remains an important public health problem in China, and adults need to be vaccinated. This systematic review and meta-analysis assessed the appropriate immunization of adults in China. Only randomized controlled trials (RCTs) were eligible, and seroprotection was defined as anti-HBs≥ 10 mIU/ml; 18,308 participants in 27 studies were included. Relative risk (RR) and random effects models were used. Twenty micrograms of HBV vaccine resulted in a better response than 10 μg (RR: 1.05, 95% confidence interval (CI): 1.02 to 1.08), and the 0-, 1-, and 6-month schedule was more effective than the 0-, 1-, and 2 - or 3-month schedule (RR: 0.98, 95% CI: 0.96 to 1.00). No significant differences were observed between 10 μg and 5 μg (RR: 1.05, 95% CI: 0.88 to 1.01); (yeast-derived hepatitis B vaccines) YDV and recombinant Chinese hamster ovary cell (CHO) hepatitis B vaccine (RR: 1.01, 95% CI: 0.98 to 1.04); domestic and imported (RR: 1.02, 95% CI: 0.99 to 1.05); or 0-, 1-, and 6-month and 0-, 1-, and 12-month schedules (RR: 1.02, 95% CI: 0.89 to 1.08). In conclusion, 20 μg of vaccine is recommended for adults in China, and the 0-, 1-, and 12-month immunization program schedule is also worth choosing when it is not possible to complete the 0-, 1-, and 6-month schedule.

PMID:
    30089437
DOI:
    10.1080/21645515.2018.1509172

StephenW

Hum Vaccin Immunother。 2018年8月8日doi：10.1080 / 21645515.2018.1509172。 [提前打印]
适合中国成人免疫接种的乙型肝炎疫苗：系统评价和荟萃分析。
吴Z1，鲍H1，姚J2，陈Y2，吕S3，李J4，江ZG2，任JJ5，徐KJ5，阮B5，杨SG5，谢TS5，胡Y2。
作者信息

1
    宁波大学医学院，浙江宁波
2
    b国家科技计划办公室，浙江省疾病预防控制中心，浙江杭州。
3
    c中国浙江省宁波市李惠里东方医院宁波医疗中心病历室
4
    d浙江省浙江省立医院病历室，浙江杭州。
五
    浙江大学医学院附属第一医院传染病诊断与治疗国家重点实验室，传染病重点实验室，浙江杭州

抽象

乙型肝炎病毒（HBV）感染仍然是中国重要的公共卫生问题，成人需要接种疫苗。本系统评价和荟萃分析评估了中国成年人的适当免疫接种情况。只有随机对照试验（RCTs）符合条件，血清保护定义为抗-HBs≥10mIU / ml;纳入了27项研究的18,308名参与者。使用相对风险（RR）和随机效应模型。 20微克HBV疫苗比10微克产生更好的反应（RR：1.05,95％可信区间（CI）：1.02至1.08），0,1和6个月的时间表比0更有效 - ，1 - 和2 - 或3个月的时间表（RR：0.98,95％CI：0.96至1.00）。在10μg和5μg之间未观察到显着差异（RR：1.05,95％CI：0.88至1.01）; （酵母来源的乙型肝炎疫苗）YDV和重组中国仓鼠卵巢细胞（CHO）乙型肝炎疫苗（RR：1.01,95％CI：0.98-1.04）;国内和进口（RR：1.02,95％CI：0.99至1.05）;或者0个月，1个月和6个月以及0个月，1个月和12个月的时间表（RR：1.02,95％CI：0.89到1.08）。总之，中国成人推荐使用20μg疫苗，当无法完成0-，1-和6-时，0-，1 - 12月和12个月免疫计划时间表也值得选择。月计划。

结论：
    30089437
DOI：
    10.1080 / 21645515.2018.1509172