慢性乙型肝炎感染的肝外表现

StephenW

Extrahepatic Manifestations of Chronic Hepatitis B Infection

    Authors
    Authors and affiliations

    Victor VirlogeuxChristian Trépo Email author

    Victor Virlogeux
        1234
    Christian Trépo
        123 Email author

    1.Service d’Hépatologie, Groupement Hospitalier NordHôpital de la Croix-Rousse, Hospices Civils de LyonLyon Cedex 04France
    2.Université Claude Bernard Lyon 1LyonFrance
    3.Inserm 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de LyonLyonFrance
    4.Department of Hepatology, Clinical Research Center (CRC), Groupement Hospitalier NordHospices Civils de LyonLyonFrance

Hepatitis B (JK Lim, Section Editor)
First Online: 13 June 2018


Part of the following topical collections:

    Topical Collection on Hepatitis B

Abstract
Purpose of Review

Hepatitis B virus (HBV) is responsible for over 350 million chronic carriers, 50% of whom will die prematurely from cirrhosis and hepatocellular carcinoma associated with T cell-mediated cytopathic immune clearance of the virus occurring over lifetime. Around 20% of acute and chronic HBV carriers are experiencing a great range of extrahepatic manifestations related to complex immunological mechanisms.
Recent Findings

Extrahepatic manifestations are due to circulating immune complexes or possibly local inflammation triggered by viral antigens and activating the complement cascade. Their mechanism and severity are unrelated to progression of liver disease. The exact viral trigger antigens remain elusive and the most likely candidates could be hepatitis B e antigen.

The spectrum of the lesion includes acute infection serum sickness, vasculitis including, polyarteritis nodosa and the most affected organs are skin, large joints, muscles, and kidneys.
Summary

Prompt awareness of these extrahepatic manifestations is now of paramount importance, since well-tolerated nucleoside analogues devoid of resistance are capable of inhibiting HBV replication and have proven not only lifesaving but remarkably also curative, like for PAN, turning as the most prophetic illustration of HBV cure.
Keywords
Hepatitis B virus Extrahepatic manifestations Vasculitis Glomerulonephritis Polyarteritis nodosa Serum-like sickness syndrome

StephenW

慢性乙型肝炎感染的肝外表现

    作者
    作者和附属机构

    VictorVirlogeuxChristianTrépo电子邮件作者

    Victor Virlogeux
        1234
    ChristianTrépo
        123电邮作者

    1.服务医院，GroupementHospitalierNordHôpitaldela Croix-Rousse，Hospices Civils de LyonLyon Cedex 04France
    2.UniversitéClaudeBernard Lyon 1LyonFrance
    3.Inserm 1052，CNRS 5286，CentreLéonBérard，Centre de RechercheenCancérologiedeLyonLyonFrance
    4.肝病学系，临床研究中心（CRC），Groupement Hospitalier NordHospices Civils de LyonLyonFrance

乙型肝炎（JK Lim，部门编辑）
首次在线：2018年6月13日


以下主题集合的一部分：

    关于乙型肝炎的局部收集

抽象
审查目的

乙型肝炎病毒（HBV）导致超过3.5亿的慢性携带者，其中50％将过早死于肝硬化和肝细胞癌，这些肝细胞癌与T细胞介导的病毒在一生中发生的细胞病变免疫清除有关。大约20％的急性和慢性HBV携带者正在经历与复杂免疫机制相关的大范围的肝外表现。
最近的调查结果

肝外表现是由于循环免疫复合物或可能由病毒抗原触发的局部炎症和激活补体级联。它们的机制和严重程度与肝病的进展无关。确切的病毒触发抗原仍然是难以捉摸的，最可能的候选者可能是乙型肝炎e抗原。

病变的范围包括急性感染血清病，血管炎，包括结节性多动脉炎和受影响最大的器官是皮肤，大关节，肌肉和肾脏。
概要

对这些肝外表现的迅速认识现在至关重要，因为耐受性良好的核苷类似物能够抑制HBV复制，并且已经证明不仅可以挽救生命，而且还可以显着治愈，就像PAN一样，是HBV最具预言性的例证。治愈。
关键词
乙型肝炎病毒肝外表现血管炎肾小球肾炎多动脉炎多动脉炎血清样疾病综合征