乙型肝炎病毒流行地区的非酒精性脂肪肝相关肝细胞癌

StephenW

Nonalcoholic fatty liver disease-associated hepatocellular carcinoma in a hepatitis B virus-endemic area

Yoon, Chang Hwi; Jin, Young-Joo; Lee, Jin Woo
European Journal of Gastroenterology & Hepatology: September 2018 - Volume 30 - Issue 9 - p 1090–1096
doi: 10.1097/MEG.0000000000001174
Original Articles: Hepatology

  Author Information
Division of Gastroenterology, Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, South Korea

Correspondence to Young-Joo Jin, MD, PhD, Division of Gastroenterology, Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, South Korea, 27 Inhang-ro, Jung-gu, Incheon, 400-711, South Korea Tel: +82 328 902 548; +fax: 82 328 902 549; e-mail: [email protected]

Received January 18, 2018

Accepted April 11, 2018

    Abstract

Background This study was carried out to evaluate the association between nonalcoholic fatty liver disease (NAFLD) and the development of hepatocellular carcinoma (HCC) between 2005 and 2015 in a hepatitis B virus (HBV)-endemic area.

Patients and methods The medical records of 1327 patients initially diagnosed with HCC at our institution between January 2005 and December 2015 were analyzed retrospectively. Patients with other malignancies in addition to HCC were excluded. During the study period, changes in the proportion of NAFLD-associated HCC among all HCCs were assessed longitudinally. In addition, the clinical characteristics of NAFLD-associated HCC were evaluated.

Results Among the 1327 patients, HBV was the most common (65.5%) cause of HCC, and the overall rate of NAFLD-associated HCC was 4.7%. Compared with HBV-associated HCC patients, NAFLD-associated HCC patients were older, had a higher median body mass index, and a larger median tumor size (P<0.05 for all). Liver cirrhosis was less frequent in NAFLD-associated than in HBV-associated HCC patients (P<0.05). The annual proportions of NAFLD-associated HCC patients were 3.4% in 2005, 3.6% in 2006, 3.5% in 2007, 3.2% in 2008, 4.2% in 2009, 4.4% in 2010, 5.6% in 2011, 5.2% in 2012, 5.8% in 2013, 7.0% in 2014, and 6.7% in 2015. From 2008 to 2015, these percentages increased steadily.

Conclusion The annual proportion of NAFLD-associated HCC patients among all HCC patients ranged from 3.2 to 3.5% before 2008, but thereafter, it increased gradually and had doubled to 7.0% by 2014.
Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

StephenW

乙型肝炎病毒流行地区的非酒精性脂肪肝相关肝细胞癌

Yoon，Chang Hwi; Jin，Young-Joo;李金佑
欧洲胃肠病学和肝病学杂志：2018年9月 - 第30卷 - 第9期 - 第1090-1096页
doi：10.1097 / MEG.0000000000001174
原创文章：肝脏病学

  作者信息
韩国仁川仁荷大学医学院仁荷大学医院内科，消化内科

韩国仁川仁荷大学医学院仁荷大学医院内科，消化内科，Young-Joo Jin，医学博士，医学博士，仁川市中区Inhang-ro，400-711，韩国电话：+82 328 902 548; +传真：82 328 902 549;电子邮件：[email protected]

收到2018年1月18日

接受2018年4月11日

    摘要作者信息

背景本研究旨在评估2005年至2015年间乙型肝炎病毒（HBV）流行区的非酒精性脂肪性肝病（NAFLD）与肝细胞癌（HCC）发展之间的关系。

患者和方法回顾性分析2005年1月至2015年12月我院最初诊断为HCC的1327例患者的病历。除HCC外还患有其他恶性肿瘤的患者被排除在外。在研究期间，纵向评估所有HCC中NAFLD相关HCC比例的变化。此外，还评估了NAFLD相关HCC的临床特征。

结果在1327例患者中，HBV是HCC最常见（65.5％）的原因，NAFLD相关HCC的总体发生率为4.7％。与HBV相关的HCC患者相比，NAFLD相关的HCC患者年龄更大，中位体重指数更高，肿瘤中位数更大（所有患者均P <0.05）。与HBV相关的HCC患者相比，NAFLD相关的肝硬化发生率较低（P <0.05）。 NAFLD相关HCC患者的年度比例在2005年为3。4％，2006年为3。6％，2007年为3。5％，2008年为3。2％，2009年为4。2％，2010年为4。4％，2011年为5。6％，2012年为5.2％， 2013年为5。8％，2014年为7。0％，2015年为6.7％。从2008年到2015年，这些比例稳步上升。

结论2008年之前，所有HCC患者中NAFLD相关HCC患者的年比例在3.2％至3.5％之间，但随后逐渐增加，到2014年翻了一番，达到7.0％。
版权所有©2018 Wolters Kluwer Health，Inc。保留所有权利。