用于HCC监测的超声波：仍在寻找算命先生。

StephenW

Liver Transpl. 2018 Jul 18. doi: 10.1002/lt.25309. [Epub ahead of print]
Ultrasound for HCC Surveillance: Still Looking for the Fortune Teller.
Foerster F1, Galle PR1.
Author information

1
    Department of Internal Medicine I, University Medical Center Mainz, Germany.

Abstract

In Philip K. Dick's short story The Minority Report (later made into a movie by Steven Spielberg), 3 fortune tellers called "precogs" predict crime before it happens, which allows the police to arrest criminals before any harm is done. Needless to say, treating malignancy before it occurs is any oncologist's ultimate dream. While such prognostic capabilities are not at our disposal today, hepatocellular carcinoma (HCC) is a kind of cancer, which typically occurs in a specified population which in turn can be kept under surveillance. Therefore, all international guidelines recommend screening measures for patients at risk who are suited for treatment.(1-3) The guidelines differ to some extent regarding patient selection, but cirrhotic patients with Child-Pugh stage A and B, noncirrhotic hepatitis B virus infected patients at increased risk of HCC, and noncirrhotic F3 patients with bridging fibrosis based on an individual risk assessment appear to be good candidates for surveillance. Here, the most widely accepted procedure is ultrasound-sometimes in combination with serum alpha-fetoprotein (AFP) measurements. This article is protected by copyright. All rights reserved.

PMID:
    30021053
DOI:
    10.1002/lt.25309

StephenW

肝脏透明。 2018年7月18日doi：10.1002 / lt.25309。 [提前打印]
用于HCC监测的超声波：仍在寻找算命先生。
Foerster F1，Galle PR1。
作者信息

1
    德国美因茨大学医学中心内科一。

抽象

在Philip K. Dick的短篇小说“少数派报告”（后来被斯蒂芬·斯皮尔伯格拍成电影）中，3名称为“预警者”的算命人员在犯罪发生之前预测犯罪，这使得警察可以在任何伤害发生之前逮捕犯罪分子。毋庸置疑，在肿瘤发生之前治疗恶性肿瘤是任何肿瘤学家的终极梦想。虽然目前我们还没有这样的预后能力，但肝细胞癌（HCC）是一种癌症，通常发生在特定的人群中，而这些癌症又可以被监视。因此，所有国际指南均建议对适合治疗的高危患者进行筛查。（1-3）指南在某些程度上与患者选择有所不同，但Child-Pugh A期和B期肝硬化患者，非肝硬化乙型肝炎病毒感染HCC风险增加的患者和基于个体风险评估的桥接纤维化的非肝硬化F3患者似乎是监测的良好候选者。在这里，最广泛接受的程序是超声 - 有时与血清甲胎蛋白（AFP）测量结合。本文受版权保护。版权所有。

结论：
    30021053
DOI：
    10.1002 / lt.25309