对原发性乙型肝炎疫苗接种具有正常和高抗体反应的成年人

StephenW

Hum Vaccin Immunother. 2018 Jul 11:1-24. doi: 10.1080/21645515.2018.1477911. [Epub ahead of print]
Persistence of immune memory among adults with normal and high antibody response to primary hepatitis B vaccination: Results from a five-year follow-up study in China.
Wu W1,2, Lv J1,2, Liu J1,2, Yan B1,2, Feng Y1,2, Xu A1,2, Zhang L1,2.
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Abstract

Immune memory after hepatitis B vaccination among adults is still under investigation. In this study, adults who had normal and high antibody response to the primary series of hepatitis B vaccination (HepB) were followed up at 5 years after the primary immunization. A booster dose was given to those who had low hepatitis B surface antibody (anti-HBs) titers, defined as anti-HBs levels < 10 mIU/mL. Blood samples were collected at two weeks after the booster and anti-HBs levels were measured. We assumed those with ant-HBs levels > = 10 mIU/mL after the booster had anamnestic response. In total, 242 persons completed the booster and the anti-HBs test. The anamnestic response rate was 99.59% (241/242) and geometric mean concentration (GMC) of anti-HBs after the booster was 2989 mIU/mL (95%CI: 255, 35085). Anti-HBs titer after the booster dose had a positive correlation with anti-HBs titers measured right after the primary immunization as well as anti-HBs titers 5 years later just before the booster. After the booster, no significant difference was found in anti-HBs titers between participants who were immunized with the 10μg HepB vaccine and those with the 20μg vaccine. Multivariable analysis showed that 1) vaccine brand used for the primary vaccination, 2) anti-HBs titers after primary vaccination and 3) anti-HBs titers before the booster dose were independently associated with the anti-HBs titers after the booster 1) β = -0.21, 95%CI: -0.33, -0.09, P = 0.001; 2) β = 0.07, 95%CI: 0.05, 0.09, P<0.001; 3) β = 0.04, 95%CI: 0.02, 0.07, P<0.001). In summary, anamnestic response exists among almost all adults at five years after HepB primary immunization. Vaccine brand used for primary vaccination, initial anti-HBs titers after primary immunization and anti-HBs titers before the booster were the independent predictive factors of HepB anamnestic response titers.
KEYWORDS:

KEYWORDS:

Adults; Booster dose; Hepatitis B vaccine; Immune memory

PMID:
    29993330
DOI:
    10.1080/21645515.2018.1477911

StephenW

Hum Vaccin Immunother。 2018年7月11日：1-24。 doi：10.1080 / 21645515.2018.1477911。 [提前打印]
对原发性乙型肝炎疫苗接种具有正常和高抗体反应的成年人的免疫记忆持续存在：中国为期五年的随访研究结果。
Wu W1,2，Lv J1,2，Liu J1,2，Yan B1,2，Feng Y1,2，Xu A1,2，Zhang L1,2。
作者信息
抽象

成人乙型肝炎疫苗接种后的免疫记忆仍在调查中。在这项研究中，对初次接种乙型肝炎疫苗的初级系列（HepB）具有正常和高抗体反应的成年人在初次免疫后5年进行随访。对乙型肝炎表面抗体（抗-HBs）滴度低的患者给予加强剂量，定义为抗-HBs水平<10 mIU / mL。在加强免疫后两周收集血样并测量抗HBs水平。我们假设在加强免疫应答后，抗-HBs水平> = 10 mIU / mL。共有242人完成了助推器和抗HBs测试。回忆后的回忆率为99.59％（241/242），抗HBs的几何平均浓度（GMC）为2989 mIU / mL（95％CI：255,35085）。加强剂量后抗-HBs滴度与初次免疫后刚刚测量的抗-HBs滴度呈正相关，5年后即在加强剂之前测定抗-HBs滴度。在加强免疫后，用10μgHepB疫苗接种的参与者与接种20μg疫苗的参与者之间的抗HBs滴度没有显着差异。多变量分析显示1）用于初次接种的疫苗品牌，2）初次接种后的抗HBs滴度和3）加强剂量前的抗HBs滴度与加强后抗HBs滴度独立相关1）β= -0.21,95％CI：-0.33，-0.09，P = 0.001; 2）β= 0.07,95％CI：0.05,0.09，P <0.001; 3）β= 0.04,95％CI：0.02,0.07，P <0.001）。总之，在HepB初次免疫后5年内，几乎所有成年人都存在记忆反应。用于初次免疫接种的疫苗品牌，初次免疫后的初始抗HBs滴度和加强前抗HBs滴度是HepB记忆反应滴度的独立预测因子。
关键词：

关键词：

成人;加强剂量;乙型肝炎疫苗;免疫记忆

结论：
    29993330
DOI：
    10.1080 / 21645515.2018.1477911