中和抗乙型肝炎病毒的研究进展及其启示

StephenW

Infect Disord Drug Targets. 2018 Jun 28. doi: 10.2174/1871526518666180628122400. [Epub ahead of print]
Recent Progress on Neutralizing Antibodies against Hepatitis B Virus and its Implications.
Hong B1, Wen Y1, Ying T1.
Author information

1
    Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Sciences, Fudan University, Shanghai 200032. China.

Abstract
BACKGROUND:

Hepatitis B virus (HBV) infection remains a global health problem. As "cure" for chronic hepatitis B is of current priority, hepatitis B immunoglobulin (HBIG) has been utilized for several decades to provide post-exposure prophylaxis. In recent years, a number of monoclonal antibodies (mAbs) targeting HBV have been developed and demonstrated with high affinity, specificity, and neutralizing potency.
OBJECTIVE:

HBV neutralizing antibodies may play potentially significant role in the search for an HBV cure. In this review, we will summarize the recently progress in developing HBV-neutralizing antibodies, describe their characteristics and potential clinical applications.
RESULTS AND CONCLUSION:

HBV neutralizing antibodies could be a promising alternative in the prevention and treatment of HBV infection. More importantly, global collaboration and coordinated approaches are thus needed to facilitate the development of novel therapies for HBV infection.

Copyright© Bentham Science Publishers; For any queries, please email at [email protected].
KEYWORDS:

HBsAg; Hepatitis B virus; neutralizing antibody

PMID:
    29952267
DOI:
    10.2174/1871526518666180628122400

StephenW

传染Disord药物目标。 2018年6月28日。doi：10.2174 / 1871526518666180628122400。 [电子版提前打印]
中和抗乙型肝炎病毒的研究进展及其启示。
Hong B1，Wen Y1，Ying T1。
作者信息

1
    复旦大学医学基础科学学院教育与卫生部医学分子病毒学重点实验室，上海200032。

摘要
背景：

乙型肝炎病毒（HBV）感染仍然是全球健康问题。由于慢性乙型肝炎的“治愈”是当前的优先事项，因此乙肝免疫球蛋白（HBIG）已用于数十年来提供暴露后预防。近年来，许多针对HBV的单克隆抗体（mAb）已经被开发出来并且以高亲和力，特异性和中和效力被证明。
目的：

HBV中和抗体可能在寻找HBV治疗中发挥重要作用。在这篇综述中，我们将总结开发HBV中和抗体的最新进展，描述它们的特点和潜在的临床应用。
结果与结论：

HBV中和抗体可能是预防和治疗HBV感染的有希望的替代方法。更重要的是，需要全球协作和协调的方法来促进HBV感染的发展。

版权所有©Bentham Science Publishers;如有任何疑问，请发送电子邮件至[email protected]。
关键词：

乙肝表面抗原;乙型肝炎病毒;中和抗体

结论：
    29952267
DOI：
    10.2174 / 1871526518666180628122400

遥望曙光

乙肝免疫球蛋白用于预防早有耳闻，现在提出用于治疗，有点意思，但感觉只能作为辅助用药

齐欢畅

马克