蔡浩东 胸腺肽类制剂治疗乙肝有效吗？

qq2019

MP4 发表于 2018-7-3 13:55
傻叉叉，是没有申请还是没有批准？混淆视听吗？

如果日仙达像干扰素一样有确切的疗效的话，

美国早就有用日仙达治疗乙肝了。

摸屁屁

MP4

qq2019 发表于 2018-7-3 14:03
如果日仙达像干扰素一样有确切的疗效的话，

美国早就有用日仙达治疗乙肝了。

复毒机，你需要发啊，发够一万贴嘛

MP4

qq2019 发表于 2018-7-3 14:03
如果日仙达像干扰素一样有确切的疗效的话，

美国早就有用日仙达治疗乙肝了。

复读机，哈哈哈哈哈哈哈哈哈哈
http://hbvhbv.info/forum/thread-1702505-1-1.html

qq2019

如果日仙达像干扰素一样有确切的疗效的话，

美国早就有用日仙达治疗乙肝了。

摸屁屁

MP4

qq2019 发表于 2018-7-3 14:14
如果日仙达像干扰素一样有确切的疗效的话，

美国早就有用日仙达治疗乙肝了。

没有申请还是没有批准？混淆视听吗？
有一样确切效果没有长效好，厂家卖孤儿药的价格不可？
傻叉叉哪条敢正面回答？

qq2019

MP4 发表于 2018-7-3 14:35
没有申请还是没有批准？混淆视听吗？
有一样确切效果没有长效好，厂家卖孤儿药的价格不可？
傻叉叉哪条敢 ...

如果日仙达像干扰素一样有确切的疗效的话，

美国早就有用日仙达治疗乙肝了。

摸屁屁

MP4

qq2019 发表于 2018-7-3 14:37
如果日仙达像干扰素一样有确切的疗效的话，

美国早就有用日仙达治疗乙肝了。

复读机，哈哈哈哈哈哈哈哈哈哈
http://hbvhbv.info/forum/thread-1702505-1-1.html

qq2019

MP4 发表于 2018-7-3 15:05
复读机，哈哈哈哈哈哈哈哈哈哈
http://hbvhbv.info/forum/thread-1702505-1-1.html

如果日仙达像干扰素一样有确切的疗效的话，

美国早就有用日仙达治疗乙肝了。

摸屁屁

qq2019

https://www.rxlist.com/zadaxin-drug.htm#indications_dosageChronic Hepatitis B

ZADAXIN thymosin alpha 1 (thymalfasin) is indicated as a monotherapy or combination therapy with interferon for the treatment of chronic hepatitis B. Pooled analysis of 3 randomized controlled trials comprising 223 patients was performed. Thymosin alpha 1 was administered twice weekly for 6 months. Follow-up assessments were performed at 12 months after completion of treatment (see table). In multiple studies, ZADAXIN (thymalfasin) was shown to have a delayed therapeutic response 12 months or longer after completion of therapy. A transient increase in ALT to more than twice baseline value (flare) can occur during ZADAXIN (thymalfasin) therapy. When ALT flare occurs, ZADAXIN (thymalfasin) should generally be continued unless signs and symptoms of liver failure are observed.

Efficacy of Thymosin Alpha 1 Monotherapy for Chronic Hepatitis B

Study Reference	Number of Patients Treatment Groups	Response Rate at 12-months follow up*
US Phase 2 [1,5]	12 Thymosin alpha 1 (1.6 mg SQ BIW 6 mos.) 8 Placebo	(83%) Thymosin alpha 1 (25%) Placebo
US Phase 3 [2,5]	50 Thymosin alpha 1 (1.6 mg SQ BIW 6 mos.) 49 Placebo	(24%) Thymosin alpha 1 (12%) Placebo
Taiwan Phase 3 [3,4,5]	51 Thymosin alpha 1 (1.6 mg SQ BIW 6 mos.) 53 No treatment	(37%) Thymosin alpha 1 (25%) No treatment
Pooled Data [5]	113 Thymosin alpha 1 (1.6 mg SQ BIW 6 mos.) 110 Placebo or no treatment	(36%) Thymosin alpha 1 (19%) Placebo or no treatment
*Response rate is defined as the percentage of subjects who were HBV DNA and HBeAg negative at 12-months follow up

REFERENCES

1. Mutchnick, M.G., Cummings, G.D., Hoofnagle, J.H., and D.A. Shafritz (1992) Thymosin: An innovative approach to the treatment of chronic hepatitis B, in Combination therapies Biological Response Modifiers in the Treatment of Cancer and Infectious Diseases, A.L Goldstein and E. Garaci, Editors. Plenum Publishing Corp: New York. p. 149-156

2. Mutchnick, M.G., Lindsay, K.L., Schiff, E.R., Cummings, G.D., and H.D. Appelman (1995) Thymosin alpha 1 treatment of chronic hepatitis B: a multicenter, randomized, placebo-controlled double blind study Gastroenterology 108(4): p. A1127

3. Lee, S.-D., D.-S. Chen, and Y.-F. Liaw (1997) Multicenter Study of Thymosin Alpha 1 in the Treatment of Chronic Hepatitis B. Data on file.

4. Chien, R.-N., Liaw Y.-F., Chen, T.-C, Yeh, C.-T., and I.-S. Sheen (1998) Efficacy of Thymosin α1 in Patients with Chronic Hepatitis B: A Randomized, Controlled TrialHepatology 27 (5) May 1998: p.1383-1387.

5. Niedzwiecki, D., Luo, D., Finn, D.S., Whiting, G.W., Connelly, J.E., Kumashiro, M., Allen, I.E. and S.D. Ross (1997) The efficacy of thymosin alpha 1 in chronic hepatitis B: a meta-analysis, Data on file.

qq2019

qq2019 发表于 2018-7-3 16:07
https://www.rxlist.com/zadaxin-drug.htm#indications_dosageChronic Hepatitis BZADAXIN thymosin alpha  ...

如果日仙达像干扰素一样有确切的疗效的话，

美国早就有用日仙达治疗乙肝了。

摸屁屁