高度升高的可溶性Tim-3水平与肝细胞癌风险增加以及慢性乙型

StephenW

Highly elevated soluble Tim-3 levels correlate with increased hepatocellular carcinoma risk and poor survival of hepatocellular carcinoma patients in chronic hepatitis B virus infection
         

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Authors Li F, Li N, Sang J, Fan X, Deng H, Zhang X, Han Q, Lv Y, Liu Z

Received 13 January 2018

Accepted for publication 5 March 2018

Published 1 May 2018 Volume 2018:10 Pages 941—951

DOI https://doi.org/10.2147/CMAR.S162478

Checked for plagiarism Yes

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Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 3

Editor who approved publication: Professor Luzhe Sun

Fang Li,1 Na Li,1 Jiao Sang,1 Xiude Fan,1 Huan Deng,1 Xiaoge Zhang,1 Qunying Han,1 Yi Lv,2,3 Zhengwen Liu1,3

1Department of Infectious Diseases, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China; 2Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China; 3Institute of Advanced Surgical Technology and Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi, China

Background and objective: Upregulated T-cell immunoglobulin and mucin domain containing molecule-3 (Tim-3) in hepatitis B virus (HBV)-specific CD8+ T-cells contributes to CD8+ T-cell exhaustion during chronic HBV infection. The membrane-bound Tim-3 can be cleaved from the cell surface by sheddase, yielding soluble Tim-3 (sTim-3). This study investigated serum sTim-3 levels in patients with chronic HBV infection of various liver diseases.
Methods: Serum sTim-3 levels were quantitatively determined in 288 patients with chronic HBV infection of various liver diseases. The sTim-3 levels were analyzed in relation to liver diseases including HBV-related hepatocellular carcinoma (HCC) and overall survival of HCC patients.
Results: Serum sTim-3 levels in the patients with chronic HBV infection were significantly elevated compared with healthy controls (P<0.001) and the levels from asymptomatic HBV carrier status, chronic hepatitis, liver cirrhosis to HCC were progressively increased. Serum sTim-3 levels were closely associated with the severity of liver function abnormalities. Importantly, serum sTim-3 levels were independently associated with HCC risk (OR, 4.310; 95% CI, 2.141–8.676, P<0.001) in comparison to non-HCC diseases in chronic HBV infection and significantly associated with the overall survival of HCC patients, with a level >3000 pg/mL being related to shorter overall survival than a level ≤3000 pg/mL (P=0.019).
Conclusion: Serum sTim-3 is involved in disease progression and HCC development in chronic HBV infection and its quantitative determination may be potentially used as a marker for monitoring the disease progression and predicting the HCC prognosis in chronic HBV infection.

Keywords: hepatitis B virus, soluble Tim-3, hepatocellular carcinoma, risk, survival

StephenW

高度升高的可溶性Tim-3水平与肝细胞癌风险增加以及慢性乙型肝炎病毒感染的肝细胞癌患者的存活不佳相关
         

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本刊中的类似文章文章列表Li F，Li N，Sang J，Fan X，Deng H，Zhang X，Han Q，Lv Y，Liu Z

收到2018年1月13日

接受公布2018年3月5日

发布日期2018年5月1日卷2018年：10页941-951

DOI https://doi.org/10.2147/CMAR.S162478

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编辑谁批准发表：鲁哲孙教授

方力1娜莉1焦相1樊秀德1桓登1张晓格1韩群英1易绿2,3刘文文1,3

1西安交通大学第一附属医院感染科，陕西西安; 2西安交通大学第一附属医院肝胆外科，陕西西安; 3西安交通大学先进外科技术与工程研究所，陕西西安

背景和目的：乙型肝炎病毒（HBV）特异性CD8 + T细胞中上调的T细胞免疫球蛋白和含黏蛋白结构域的分子-3（Tim-3）有助于慢性HBV感染期间CD8 + T细胞耗竭。膜结合的Tim-3可以通过脱落酶从细胞表面切割，产生可溶性Tim-3（sTim-3）。本研究调查了慢性HBV感染各种肝病患者血清sTim-3水平。
方法：对288例慢性HBV感染各种肝病患者血清sTim-3水平进行定量测定。分析sTim-3水平与包括HBV相关肝细胞癌（HCC）在内的肝脏疾病和HCC患者的总体存活率。
结果：慢性乙型肝炎患者血清sTim-3水平与健康对照组相比明显升高（P <0.001），无症状HBV携带者状态，慢性肝炎，肝硬化肝癌患者血清sTim-3水平逐渐升高。血清sTim-3水平与肝功能异常的严重程度密切相关。重要的是，与慢性HBV感染的非HCC疾病相比，血清sTim-3水平与HCC独立相关（OR为4.310; 95％CI为2.141-8.676，P <0.001），与HCC的总体生存率显着相关患者，其水平> 3000 pg / mL与总体生存时间短于≤3000 pg / mL相关（P = 0.019）。
结论：血清sTim-3参与了慢性HBV感染的疾病进展和HCC发展，其定量测定可能有望作为监测慢性HBV感染的疾病进展和预测HCC预后的指标。

关键词：乙型肝炎病毒，可溶性Tim-3，肝癌，风险，生存