科学家发明“免疫凝胶”，或可大幅降低术后癌症复发转移

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科学家发明“免疫凝胶”，或可大幅降低术后癌症复发转移风险http://m.x-mol.com/news/12031?webTitle=xmol.news.webTitle&titleArg1=%E3%80%8A%E7%A7%91%E5%AD%A6%E3%80%8B%E5%AD%90%E5%88%8A%EF%BC%9A%E6%9C%AF%E5%90%8E%E8%B4%B4%E4%B8%80%E7%89%87%EF%BC%8C%E5%A4%8D%E5%8F%91%E8%BD%AC%E7%A7%BB%E9%9D%A0%E8%BE%B9%E7%AB%99%EF%BC%81%E7%A7%91%E5%AD%A6%E5%AE%B6%E5%8F%91%E6%98%8E%E2%80%9C%E5%85%8D%E7%96%AB%E5%87%9D%E8%83%B6%E2%80%9D%EF%BC%8C%E6%88%96%E5%8F%AF%E5%A4%A7%E5%B9%85%E9%99%8D%E4%BD%8E%E6%9C%AF%E5%90%8E%E7%99%8C%E7%97%87%E5%A4%8D%E5%8F%91%E8%BD%AC%E7%A7%BB%E9%A3%8E%E9%99%A9&webKeywords=xmol.news.webKeywords&keywordArg1=%E5%85%8D%E7%96%AB%E5%87%9D%E8%83%B6%EF%BC%9B+%E7%99%8C%E7%97%87%E5%A4%8D%E5%8F%91&webDescription=xmol.news.webDescription&webDescriptionArg1=%E3%80%8A%E7%A7%91%E5%AD%A6%E3%80%8B%E5%AD%90%E5%88%8A%EF%BC%9A%E6%9C%AF%E5%90%8E%E8%B4%B4%E4%B8%80%E7%89%87%EF%BC%8C%E5%A4%8D%E5%8F%91%E8%BD%AC%E7%A7%BB%E9%9D%A0%E8%BE%B9%E7%AB%99%EF%BC%81%E7%A7%91%E5%AD%A6%E5%AE%B6%E5%8F%91%E6%98%8E%E2%80%9C%E5%85%8D%E7%96%AB%E5%87%9D%E8%83%B6%E2%80%9D%EF%BC%8C%E6%88%96%E5%8F%AF%E5%A4%A7%E5%B9%85%E9%99%8D%E4%BD%8E%E6%9C%AF%E5%90%8E%E7%99%8C%E7%97%87%E5%A4%8D%E5%8F%91%E8%BD%AC%E7%A7%BB%E9%A3%8E%E9%99%A9

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Sci Transl Med. 2018 Mar 21;10(433). pii: eaar1916. doi: 10.1126/scitranslmed.aar1916.
Extended release of perioperative immunotherapy prevents tumor recurrence and eliminates metastases.

Park CG1,2,3, Hartl CA1, Schmid D1,2, Carmona EM1,2, Kim HJ1,2, Goldberg MS4,2.
Author information
Abstract
Cancer immunotherapy can confer durable benefit, but the percentage of patients who respond to this approach remains modest. The ability to concentrate immunostimulatory compounds at the site of disease can overcome local immune tolerance and reduce systemic toxicity. Surgical resection of tumors may improve the efficacy of immunotherapy by removing the concentrated immunosuppressive microenvironment; however, it also removes tumor-specific leukocytes as well as tumor antigens that may be important to establishing antitumor immunity. Moreover, surgery produces a transient immunosuppressive state associated with wound healing that has been correlated with increased metastasis. Using multiple models of spontaneous metastasis, we show that extended release of agonists of innate immunity-including agonists of Toll-like receptor 7/8 (TLR7/8) or stimulator of interferon genes (STING)-from a biodegradable hydrogel placed in the tumor resection site cured a much higher percentage of animals than systemic or local administration of the same therapy in solution. Depletion and neutralization experiments confirmed that the observed prevention of local tumor recurrence and eradication of existing metastases require both the innate and adaptive arms of the immune system. The localized therapy increased the numbers of activated natural killer (NK) cells, dendritic cells, and T cells and induced production of large amounts of type I interferons, thereby converting an immunosuppressive post-resection microenvironment into an immunostimulatory one. The results suggest that the perioperative setting may prove to be a useful context for immunotherapy, particularly when the release of the therapy is extended locally.
PMID: 29563317 DOI: 10.1126/scitranslmed.aar1916

桦子

Sci Transl Med。 2018年3月21日; 10（433）。 pii：eaar1916。 doi：10.1126 / scitranslmed.aar1916。
围手术期免疫治疗的延长释放预防肿瘤复发并消除转移。

Park CG1,2,3，Hartl CA1，Schmid D1,2，Carmona EM1,2，Kim HJ1,2，Goldberg MS4,2。
作者信息
抽象
癌症免疫治疗可以赋予持久的益处，但对这种方法作出反应的患者百分比仍然不高。将免疫刺激性化合物集中在疾病部位的能力可以克服局部免疫耐受性并降低全身毒性。肿瘤的手术切除可以通过去除浓缩的免疫抑制微环境来提高免疫疗法的效力;然而，它也去除了肿瘤特异性白细胞以及可能对建立抗肿瘤免疫性重要的肿瘤抗原。此外，手术产生与创伤愈合相关的瞬时免疫抑制状态，其与增加的转移相关。使用多种自发转移模型，我们显示先天免疫激动剂（包括Toll样受体7/8（TLR7 / 8）激动剂或干扰素基因刺激剂（STING））从放置在肿瘤中的生物可降解水凝胶中延长释放切除部位治愈的动物百分比高于在溶液中全身或局部施用相同疗法的动物百分比。耗竭和中和实验证实，观察到的局部肿瘤复发的预防和根除现有的转移需要免疫系统的先天性和适应性臂。局部治疗增加了活化的自然杀伤（NK）细胞，树突细胞和T细胞的数量并诱导大量I型干扰素的产生，从而将免疫抑制性切除后微环境转化为免疫刺激性微环境。结果表明，围手术期设置可能被证明是免疫治疗的有用环境，特别是当局部延长治疗的释放时。
PMID：29563317 DOI：10.1126 / scitranslmed.aar1916

newchinabok

MP4 发表于 2018-4-11 19:35
Sci Transl Med. 2018 Mar 21;10(433). pii: eaar1916. doi: 10.1126/scitranslmed.aar1916.
Extended rele ...

驴，现在重要的是治乙肝，而不是治癌症，你发癌版好么？

MP4

newchinabok 发表于 2018-4-12 11:55
驴，现在重要的是治乙肝，而不是治癌症，你发癌版好么？

你才驴，你这垃圾水平谦虚点，无法认同你的观点，应该发什么发什么版什么重要比你清楚多了，不需要你指指点点。

newchinabok

回复 MP4 的帖子

你是蠢驴，还是倔驴呀

MP4

newchinabok 发表于 2018-4-12 12:07
回复 MP4 的帖子

你是蠢驴，还是倔驴呀

是你驴踢还没好，赶紧去治

疯一点好

我们这些乙肝患者就是希望能多点看到这些文章，请不要无事挑事端，各行各珍重。

newchinabok

回复 疯一点好 的帖子

大家身体有病，要给大家正能量，天天谈癌，对大家心理伤害还不够吗？，大家身在乙肝阴影中，还要大家身在肝癌阴影中，这样好么？你说我说的对吗？我天天发新药信息，就是给大家希望，认为可以治愈，摆脱疾病，对心理健康是不是有好的暗示了呢？如果你想看，mp4想发，可以去癌版嘛，也可以加微信好友私聊都行。为什么要把自己的负能量传递大家呢？

newchinabok

如果有脆弱的战友，天天发癌的文章吓人，好吗？不是不关心癌，也不能草木皆兵