中医肝损伤的临床特点和结局：系统评价

StephenW

Clinical characteristics and outcomes of traditional Chinese medicine-induced liver injury: a systematic review
Ran Wang, Xingshun Qi ORCID Icon, Eric M. Yoshida, Nahum Méndez-Sánchez, Rolf Teschke, Mingyu Sun, show all
Pages 425-434 | Received 08 Nov 2017, Accepted 10 Jan 2018, Accepted author version posted online: 11 Jan 2018, Published online: 18 Jan 2018

    Download citation https://doi.org/10.1080/17474124.2018.1427581



ABSTRACT

Backgrounds: Traditional Chinese medicine (TCM) is becoming increasingly popular and related adverse events are often ignored or underestimated.

Aims: This systematic review aimed to evaluate the clinical characteristics and outcomes of TCM-induced liver injury (TCM-ILI) and to estimate the proportion of TCM-ILI in all drug-induced liver injuries (DILI).

Methods: China National Knowledge Infrastructure, Wanfang, VIP, PubMed, and Embase databases were searched. Demographic, clinical, and survival data were extracted and pooled. Factors associated with worse outcomes were calculated. For the proportion meta-analyses, the data were pooled by using a random-effects model.

Results: Overall, 21,027 articles were retrieved, of which 625 were finally included. There was a predominance of female and older patients. The proportion of liver transplantation was 2.18% (7/321). The mortality was 4.67% (15/321). Male, higher aspartate aminotransferase and direct bilirubin, and lower albumin were significantly associated with an increased risk of death/liver transplantation in TCM-ILI patients. The proportion of TCM-ILI in all DILI was 25.71%. The proportion was gradually increased with year.

Conclusions: Our work summarises current knowledge regarding clinical presentation, disease course, and prognosis of TCM-ILI. TCM can result in hepatotoxicity, even death or necessitate life-saving liver transplantation. Governmental regulation of TCM products should be strictly established.
KEYWORDS: TCM, traditional Chinese medicine, TCM-ILI, TCM-induced liver injury, CNKI, China National Knowledge Infrastructure, DILI, drug-induced liver injury, RUCAM, Roussel Uclaf Causality Assessment Method, ALT, alanine aminotransferase, ULN, upper limit of normal, ALP, alkaline phosphatase, SD, standard deviation

StephenW

中医肝损伤的临床特点和结局：系统评价
Ran Wang，Xingshun Qi ORCID Icon，Eric M. Yoshida，NahumMéndez-Sánchez，Rolf Teschke，Mingyu Sun，展示所有
页425-434 |收到2017年11月8日，接受2018年1月10日，接受作者版本在线发布：2018年1月11日，在线发布：2018年1月18日

    下载引文https://doi.org/10.1080/17474124.2018.1427581



抽象

背景：中药（TCM）日益流行，相关的不良事件往往被忽视或低估。

目的：本系统综述旨在评估中医药所致肝损伤（TCM-ILI）的临床特征和预后，并评估所有药物性肝损伤（DILI）中TCM-ILI的比例。

方法：搜集国家知识基础设施，万方，VIP，PubMed和Embase数据库。提取人口统计学，临床和生存数据并合并。计算了与较差结果相关的因素。对于比例荟萃分析，数据通过使用随机效应模型进行汇总。

结果：总共检索了21,027篇文章，其中625篇最终被收录。女性和老年患者占优势。肝移植比例为2.18％（7/321）。死亡率为4.67％（15/321）。男性，高级天冬氨酸转氨酶和直接胆红素以及低白蛋白与中医ILI患者死亡/肝移植风险增加显着相关。所有DILI中TCM-ILI的比例为25.71％。这一比例随着年份逐渐增加。

结论：我们的工作总结了目前关于中医ILI临床表现，病程和预后的知识。中医药可导致肝毒性，甚至死亡或需要救命的肝移植。政府对中医药产品的监管要严格制定。
关键词：中医药，中医药，中医药ILI，中医药肝损伤，CNKI，中国知识基础设施，DILI，药物性肝损伤，RUCAM，Roussel Uclaf因果关系评估法，ALT，丙氨酸转氨酶，ULN，上限正常，ALP，碱性磷酸酶，SD，标准差

neilhbver

中医药，印度神油，印第安草药，雅利安草药...