由于主要危险因素导致的肝细胞癌病例的全球发病率

StephenW

Eur J Cancer Prev. 2018 Feb 27. doi: 10.1097/CEJ.0000000000000428. [Epub ahead of print]
Worldwide incidence of hepatocellular carcinoma cases attributable to major risk factors.Baecker A1, Liu X1,2, La Vecchia C3, Zhang ZF1,4,5.
Author information
1Department of Epidemiology, Fielding School of Public Health.2Department of Epidemiology, School of Public Health, Fudan University, Shanghai, People's Republic of China.3Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.4Healthy and At-Risk Populations Program, Jonsson Comprehensive Cancer Center.5Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California, USA.

AbstractTo facilitate regionally specific liver cancer prevention and control, this study estimates the fraction of hepatocellular carcinoma (HCC) cases attributable to five major liver cancer risk factors by geographic region. Prevalence estimates of major HCC risk factors, including chronic infection with hepatitis B and hepatitis C, alcohol drinking, tobacco smoking, obesity, and diabetes, were extracted for each country from the literature, along with recent incidence and risk estimate data, to calculate regionally specific population attributable fractions. Overall, 44% of HCC cases worldwide were attributable to chronic hepatitis B infection, with the majority of cases occurring in Asia. Hepatitis C was responsible for 21% of cases. Lifestyle risk factors such as alcohol drinking and obesity were responsible for a larger percentage of cases in North America and Western, Central, and Eastern Europe. In addition, strong sex disparities were observed when looking at lifestyle risk factors, particularly tobacco smoking, in Asia and Africa. Prominent risk factors for HCC vary depending on the region. Our findings provide useful data for developing regionally specific guidelines for liver cancer prevention and control worldwide.


PMID:29489473DOI:10.1097/CEJ.0000000000000428

StephenW

Eur J癌症上一页。 2018年2月27日。doi：10.1097 / CEJ.0000000000000428。 [电子版提前打印]
由于主要危险因素导致的肝细胞癌病例的全球发病率。
Baecker A1，Liu X1,2，La Vecchia C3，Zhang ZF1,4,5。
作者信息

1
    公共卫生菲尔丁流行病学系。
2
    中华人民共和国上海复旦大学公共卫生学院流行病学系。
3
    米兰大学临床科学和社区卫生系，意大利米兰。
4
    健康和风险人群项目，Jonsson综合癌症中心。
五
    美国加利福尼亚大学洛杉矶分校David Geffen医学院人类营养中心。

抽象

为了促进区域特异性肝癌的预防和控制，本研究根据地理区域估算了归因于五种主要肝癌风险因素的肝细胞癌（HCC）病例的比例。从文献中提取每个国家的主要HCC危险因素（包括慢性乙型肝炎和丙型肝炎感染，饮酒，吸烟，肥胖和糖尿病）的流行率估计值，以及最近的发病率和风险估计数据，以便在地区特定人群归因分数。总体而言，全球44％的HCC病例归因于慢性乙型肝炎感染，大部分病例发生在亚洲。丙型肝炎占21％的病例。北美和西欧，中欧和东欧的生活方式风险因素，例如酗酒和肥胖是造成较大比例的病例的原因。此外，在亚洲和非洲考察生活方式风险因素，特别是吸烟时，观察到强烈的性别差异。 HCC的突出风险因素因地区而异。我们的研究结果为制定全球肝癌预防和控制的区域性具体指南提供了有用的数据。

结论：
    29489473
DOI：
    10.1097 / CEJ.0000000000000428