慢性乙型肝炎患者不同感染阶段血清α-甲胎蛋白水平的评估

StephenW

Clin Lab. 2018 Jan 1; 64 (1): 43-49. Doi: 10.7754 / Clin. Lab. 2017.170526.
Evaluation of Serum α-Fetoprotein Levels During Different Infection Phases of CHB Patients.
Yang N, Feng J, Li ZR, Ming KH, Lei XX, Xu BL.
Abstract
BACKGROUND:

Chronic hepatitis B patients carry a high risk of developing hepatocellular carcinoma (HCC). Α-Fetoprotein (AFP) is one of the most commonly used and reliable biomarkers for HCC. However, the AFP level during different phases of CHB is not well understood. We aimed to identify the AFP levels during the different infection of of CHB patient and explore which phase is at high risk of developing HCC.
METHODS:

Immune tolerant HBeAgpositive phase (IT); b. Immune reactive HBeAg-positive phase (IR), c. Inactive carrier state (IC), d. HBeAg-negative activation phase (ENA). The risk of developing of HCC in different groups is assessed by the serum AFP levels. An electrochemiluminescence assay was used to analyze serum AFP levels.
RESULTS:

Mean AFP levels were different in each phase of CHB (p <0.001): IT (9.6 ng / mL), IR (33.7 ng / mL), IC (3.2 ng / mL), and ENA A significant correlation between serum ALT levels and HBV viral load was observed (r = 0.272, p <0.01).
CONCLUSIONS:

These findings suggest that high levels of AFP during HBeAg-negative activation phase (ENA) may be associated with a high risk of developing of HCC.

PMID:
    2947989

StephenW

临床实验室。 2018年1月1日; 64（1）：43-49。土井：10.7754 /临床。实验室。 2017.170526。
慢性乙型肝炎患者不同感染阶段血清α-甲胎蛋白水平的评估。
Yang N，Feng J，Li ZR，Ming KH，Lei XX，Xu BL。
抽象
背景：

慢性乙型肝炎患者发展为肝细胞癌（HCC）的高风险。 A-Fetoprotein（AFP）是HCC最常用和最可靠的生物标志物之一。然而，CHB不同阶段的法新社水平并不清楚。我们旨在确定慢性乙型肝炎患者不同感染期间的AFP水平，并探索哪个阶段发生HCC的高风险。
方法：

免疫耐受HBeAgpositive阶段（IT）;湾免疫反应性HBeAg阳性期（IR），c。无效载波状态（IC），d。 HBeAg阴性激活期（ENA）。血清AFP水平评估不同组别HCC发展的风险。电化学发光测定法用于分析血清AFP水平。
结果：

在CHB的各个阶段（p <0.001），平均AFP水平不同：IT（9.6ng / mL），IR（33.7ng / mL），IC（3.2ng / mL）和ENA血清ALT水平与观察到HBV病毒载量（r = 0.272，p <0.01）。
结论：

这些发现表明，在HBeAg阴性激活期（ENA）期间高水平的AFP可能与HCC发展的高风险相关。

结论：
2947989