慢性乙型肝炎患者不同感染阶段血清α-甲胎蛋白水平的评估

StephenW

Clin Lab. 2018 Jan 1;64(1):43-49. doi: 10.7754/Clin.Lab.2017.170526.
Evaluation of Serum α-Fetoprotein Levels During Different Infection Phases of CHB Patients.Yang N, Feng J, Li ZR, Ming KH, Lei XX, Xu BL.
AbstractBACKGROUND: Chronic hepatitis B patients carry a high risk of developing hepatocellular carcinoma (HCC). α-Fetoprotein (AFP) is one of the most commonly used and reliable biomarkers for HCC. However, the AFP level during different phases of CHB is not well understood. We aimed to identify the AFP levels during the different infection phases of CHB patient and explore which phase is at high risk of developing HCC.
METHODS: Three hundred and fifty-five CHB patients were divided into four groups: a. immune tolerant HBeAgpositive phase (IT); b. immune reactive HBeAg-positive phase (IR), c. inactive carrier state (IC), d. HBeAg-negative activation phase (ENA). The risk of development of HCC in different group is assessed by the serum AFP levels. An electrochemiluminescence assay was used to analyze serum AFP levels.
RESULTS: Mean AFP levels were different in each phase of CHB (p < 0.001): IT (9.6 ng/mL), IR (33.7 ng/mL), IC (3.2 ng/mL), and ENA (71.6 ng/mL). The ENA phase had the highest AFP level and IC phase has the lowest. There was no correlation between serum AFP level and HBV viral load. A significant correlation between serum ALT levels and HBV viral load was observed (r = 0.272, p < 0.01).
CONCLUSIONS: These findings suggest that high levels of AFP during HBeAg-negative activation phase (ENA) may be associated with a high risk of developing of HCC. Furthermore, higher burden of HBV viral load is associated with more severe liver damage.


PMID:29479896

StephenW

临床实验室。 2018年1月1日; 64（1）：43-49。 doi：10.7754 / Clin.Lab.2017.170526。
慢性乙型肝炎患者不同感染阶段血清α-甲胎蛋白水平的评估。
Yang N，Feng J，Li ZR，Ming KH，Lei XX，Xu BL。
抽象
背景：

慢性乙型肝炎患者发展为肝细胞癌（HCC）的高风险。 α-甲胎蛋白（AFP）是HCC最常用和最可靠的生物标志物之一。然而，CHB不同阶段的法新社水平并不清楚。我们旨在确定慢性乙型肝炎患者不同感染阶段的AFP水平，并探索哪个阶段发生HCC的高风险。
方法：

将350名慢性乙型肝炎患者分为四组：a。免疫耐受HBeAg阳性阶段（IT）;湾免疫反应性HBeAg阳性期（IR），c。无效载波状态（IC），d。 HBeAg阴性激活期（ENA）。血清AFP水平评估不同组别HCC发展的风险。电化学发光测定法用于分析血清AFP水平。
结果：

IT（9.6 ng / mL），IR（33.7 ng / mL），IC（3.2 ng / mL）和ENA（71.6 ng / mL）的平均AFP水平在CHB的各个阶段（p <0.001）都不同。 ENA阶段的AFP水平最高，IC阶段的水平最低。血清AFP水平与HBV病毒载量无相关性。观察到血清ALT水平和HBV病毒载量之间的显着相关性（r = 0.272，p <0.01）。
结论：

这些发现表明，在HBeAg阴性激活期（ENA）期间高水平的AFP可能与HCC发展的高风险相关。此外，更高的HBV病毒载量负担与更严重的肝损伤相关。

结论：
    29479896

jdcy

这个能看懂！