非酒精性脂肪肝患者的危险因素和代谢异常：非肥胖或肥胖

StephenW

Hepatobiliary Pancreat Dis Int. 2018 Feb;17(1):45-48. doi: 10.1016/j.hbpd.2018.01.007. Epub  2018 Jan 31.
Risk factors and metabolic abnormality of patients with non-alcoholic fatty liver disease: Either non-obese or obese Chinese population.Lee SW1, Lee TY2, Yang SS2, Tung CF2, Yeh HZ2, Chang CS2.
Author information

AbstractBACKGROUND: Non-alcoholic fatty liver disease (NAFLD) occurs not only in obese individuals but also in non-obese ones. The aim of this study was to focus on the association between NAFLD and metabolic events in a non-obese or obese Chinese population.
METHODS: Data collected from subjects registered at Taichung Veterans General Hospital from January to December 2009 were analyzed. The exclusion criteria were alcoholics, chronic hepatitis B or C. Patients included in analyses were assigned to four groups according to sonography of their liver (normal or NAFLD), and body mass index (BMI) levels (non-obese if BMI < 25 kg/m2 or obese if BMI ≥ 25 kg/m2).
RESULTS: There were 745, 208, 770 and 285 patients enrolled in four groups labeled non-obese normal liver (group A), non-obese NAFLD (group B), obese normal liver (group C) and obese NAFLD (group D), respectively. The highest ratio of metabolic syndrome existed in the group B (26.9%), followed by group A (11.7%), group D (10.9%) and finally the group C (5.2%). The positive association with NAFLD in non-obese individuals was significant in triglyceride (OR = 1.01; 95% CI: 1.01-1.02) and glucose (OR = 1.02; 95% CI: 1.01-1.03), while the positive association with NAFLD in obese subjects was only significant in triglyceride (OR = 1.01; 95% CI: 1.01-1.02). The positive association was most significant in all cases (adjusted OR = 2.41; 95% CI: 1.78-3.24), especially in non-obese individuals (OR = 2.81; 95% CI: 1.92-4.12).
CONCLUSIONS: Non-obese NAFLD subjects displayed a higher proportion of metabolic abnormality. Hyperlipidemia and hyperglycemia had the most positive strength association with NAFLD.

Copyright © 2018 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved.

KEYWORDS: Chinese population; Fatty liver; Non-alcoholic fatty liver disease; Obese

PMID:29428103DOI:10.1016/j.hbpd.2018.01.007

StephenW

肝胆胰胰腺疾病2018年2月; 17（1）：45-48。 doi：10.1016 / j.hbpd.2018.01.007。电子杂志2018年1月31日。
非酒精性脂肪肝患者的危险因素和代谢异常：非肥胖或肥胖的中国人群。
Lee SW1，Lee TY2，Yang SS2，Tung CF2，Yeh HZ2，Chang CS2。
作者信息
抽象
背景：

非酒精性脂肪肝病（NAFLD）不仅发生在肥胖个体中，而且发生在非肥胖个体中。本研究的目的是关注NAFLD与非肥胖或肥胖中国人群中代谢事件之间的关联。
方法：

分析了从2009年1月至12月在台中退伍军人医院登记的受试者收集的数据。排除标准为酗酒者，慢性乙型肝炎或丙型肝炎。纳入分析的患者根据其肝脏超声检查（正常或NAFLD）和体重指数（BMI）水平（如果BMI <25kg非肥胖/ m2或BMI≥25kg/ m2时肥胖）。
结果：

分别标记为非肥胖正常肝脏（A组），非肥胖NAFLD（B组），肥胖正常肝脏（C组）和肥胖NAFLD（D组）的745例，208例，770例和285例患者。 B组代谢综合征率最高（26.9％），其次是A组（11.7％），D组（10.9％），最后是C组（5.2％）。在非肥胖个体中NAFLD与甘油三酯（OR = 1.01; 95％CI：1.01-1.02）和葡萄糖（OR = 1.02; 95％CI：1.01-1.03）呈显着正相关，而与NAFLD呈正相关肥胖受试者仅在甘油三酯中显着（OR = 1.01; 95％CI：1.01-1.02）。在所有病例中，阳性关联最为显着（调整OR = 2.41; 95％CI：1.78-3.24），特别是在非肥胖个体中（OR = 2.81; 95％CI：1.92-4.12）。
结论：

非肥胖NAFLD受试者表现出更高比例的代谢异常。高脂血症和高血糖与NAFLD有最强的正相关性。

版权所有©2018浙江大学医学院附属第一医院。由Elsevier B.V.出版。保留所有权利。
关键词：

中国人口;脂肪肝;非酒精性脂肪肝病;肥胖

结论：
    29428103
DOI：
    10.1016 / j.hbpd.2018.01.007