不同剂量和时间表的乙肝疫苗在中国健康青年中的免疫原性

StephenW

Hum Vaccin Immunother. 2018 Feb 8:0. doi: 10.1080/21645515.2018.1438090. [Epub ahead of print]
Comparison of immunogenicity between hepatitis B vaccines with different dosages and schedules among healthy young adults in China: A 2-year follow-up study.Wang ZZ1,2, Gao YH1, Wang P3, Wei L3, Xie CP3, Yang ZX3, Lan J3, Fang ZL4, Zeng Y5, Yan L1, Liu XE1, Zhuang H1.
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AbstractImmunogenicity of hepatitis B vaccine between 20 μg with 3-dose schedule and 60 μg with 2-dose regimens was compared 2 years after primary immunization. A total of 353 healthy adults aged 18-25 years were enrolled in the study and randomly assigned (1: 1: 1) into 3 vaccine groups: A (20 μg, 0-1-6 month), B (60 μg, 0-1 month) and C (60 μg, 0-2 month). Serum samples were collected at 1 month after a series vaccination and 12 months, 24 months after the first-dose. The GMC level of anti-HBs antibody was measured using Chemiluminescent Microparticle ImmunoAssay (CMIA). There were 59, 45 and 55 vaccinees available to follow-up with 2year later in vaccine groups A, B and C, respectively. No significant differences existed in sex ratio, age and body mass index (BMI) among vaccinees at month 24 and the corresponding participants at baseline in each group (P > 0.05). The seroprotection rates in group A, B and C were 98.31%, 88.37% and 85.19%, respectively (P = 0.014), reflecting the fact that the rate of group A was significantly higher than that in group C (P = 0.026). Also, the GMC level of anti-HBs antibody in group A was significantly higher than those of other two groups (427.46 mIU/ml vs. 89.74 mIU/ml, 89.80 mIU/ml, respectively; all P < 0.01). This data suggested that the standard 20 μg (0-1-6 month) regimen of hepatitis B vaccine should be recommended as a priority on the premise of complete compliance in adults.


KEYWORDS: Follow-up study; Hepatitis B Vaccine; High dosage; Immunogenicity; Young adults

PMID:29420134DOI:10.1080/21645515.2018.1438090

StephenW

嗡嗡声Vaccin Immunother。 2018年2月8日：0。 doi：10.1080 / 21645515.2018.1438090。 [电子版提前打印]
不同剂量和时间表的乙肝疫苗在中国健康青年中的免疫原性比较：一项为期2年的随访研究。
王志忠1,2，高玉海1，王鹏3，魏麟3，谢红3，杨志祥3，兰3 3，方肇礼4，曾晔5，严立1，刘晓娥1，庄H1 1。
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在初次免疫2年后比较了20μg与3个剂量方案和60μg与2个剂量方案之间的乙型肝炎疫苗的免疫原性。共有353名年龄在18-25岁的健康成年人被纳入本研究，随机分配（1：1：1）到3个疫苗组中：A（20μg，0-1-6个月），B（60μg，0 -1个月）和C（60μg，0-2个月）。在一系列接种疫苗后1个月和第一次接种24个月后收集血清样品。使用化学发光微粒免疫分析（CMIA）测量抗-HBs抗体的GMC水平。 A，B和C组分别有59,45和55名接种者可以随访2年。各组间性别比例，年龄和体质量指数（BMI）在24个月及相应参与者基线水平均无显着性差异（P> 0.05）。 A组，B组和C组的血清保护率分别为98.31％，88.37％和85.19％（P = 0.014），反映A组明显高于C组（P = 0.026）。 A组抗-HBs抗体GMC水平显着高于其他两组（427.46 mIU / ml比89.74 mIU / ml，89.80 mIU / ml，均P <0.01）。这个数据表明，在成人完全依从的前提下，建议将20μg（0-1-6个月）的标准乙肝疫苗作为优先考虑事项。
关键词：

后续研究;乙型肝炎疫苗;高剂量;免疫原性;年轻人

结论：
    29420134
DOI：
    10.1080 / 21645515.2018.1438090