中国肝切除42753例：多中心回顾性调查。

StephenW

Sci China Life Sci. 2018 Feb 2. doi: 10.1007/s11427-017-9259-9. [Epub ahead of print]
42,573 cases of hepatectomy in China: a multicenter retrospective investigation.Zhang B1, Zhang B1, Zhang Z1, Huang Z1, Chen Y1, Chen M2, Bie P3, Peng B4, Wu L5, Wang Z6, Li B7, Fan J8, Qin L9, Chen P10, Liu J11, Tang Z12, Niu J13, Yin X14, Li D15, He S16, Jiang B17, Mao Y18, Zhou W19, Chen X20.
Author information
1Institute of Hepato-pancreato-bililary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.2Cancer Hospital of Sun Yat-sen University, Guangzhou, 510060, China.3Southwest Hospital, Chongqing, 400038, China.4The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.5Affiliated Hospital of Qingdao Medical College, Qingdao, 266071, China.6Xiangya Hospital, Changsha, 410008, China.7West China Hospital, Chengdu, 610041, China.8Zhongshan Hospital of Fudan University, Shanghai, 200032, China.9Huashan Hospital of Fudan University, Shanghai, 100044, China.10Daping Hospital, the Third Military Medical University, Chongqing, 400042, China.11Mengchao Hepatobiliary Hospital, Fuzhou, 350025, China.12The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.13Qilu Hospital of Shandong University, Jinan, 250012, China.14Hunan People's Hospital, Changsha, 410002, China.15Henan People's Hospital, Zhengzhou, 450003, China.16The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.17Taihe Hospital, Shiyan, 442000, China.18Union Hospital, Beijing, 100032, China. [email protected].19Eastern Hepatobiliary Surgery Hospital, Shanghai, 201805, China. [email protected].20Institute of Hepato-pancreato-bililary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. [email protected].

AbstractHepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma (HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients, 81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein (AFP) level, and other 35% had an AFP level lower than 400 ng mL-1. In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was (191.7±105.6) min, the blood loss was (546.0±562.8) mL, and blood transfusion was (543.0±1,035.2) mL. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules, tumor thrombosis and high AFP level were risk factors that affect postoperative survival.


KEYWORDS: China; hepatectomy; hepatocellular carcinoma

PMID:29417360DOI:10.1007/s11427-017-9259-9

StephenW

科学中国人寿科学。 2018年2月2日，doi：10.1007 / s11427-017-9259-9。 [电子版提前打印]
中国肝切除42753例：多中心回顾性调查。
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作者信息

1
华中科技大学同济医学院附属同济医院肝胆外科研究所，武汉430030
2
中山大学肿瘤医院，广州510060
3
重庆市西南医院，400038
4
中山大学附属第一医院，广州，510080
五
青岛医学院附属医院，青岛266071
6
湖南湘雅医院，410008
7
华西医院，成都610041
8
复旦大学附属中山医院，上海，200032
9
上海，复旦大学附属华山医院，上海，100044
10
第三军医大学大坪医院，重庆400042
11
孟超肝胆医院，福州350025
12
郑州大学第一附属医院，郑州450052
13
山东大学齐鲁医院，济南250012
14
湖南省人民医院，湖南长沙410002
15
河南省人民医院，郑州450003
16
广西医科大学附属第一医院，南宁，530021
17
太原医院，十堰，442000
18
北京协和医院，100032 [email protected]。
19
东方肝胆外科医院，上海，201805 [email protected]。
20
华中科技大学同济医学院附属同济医院肝胆外科研究所，武汉430030 [email protected]。

抽象

中国拥有最多的肝病人数和最多的肝切除病例。对112例医院进行了全国范围的多中心回顾性调查，重点对肝癌患者进行肝脏切除术（纳入4273例肝癌切除患者，选择18275例HCC患者肝脏切除术有效病例进行统计分析，HCC流行病学，分析肝切除情况，术后并发症及预后情况，18,275例HCC患者中，乙型肝炎病毒感染率为81％，丙型肝炎病毒感染率为10％，HCC患者中甲胎蛋白（AFP）水平为38％其他35％的患者AFP水平低于400 ng mL-1。在研究期间，97％的HCC肝切除患者接受开放手术治疗，23.81％的患者接受了血管排除技术，手术时间为（191.7±105.6） （546.0±562.8）mL，输血量为（543.0±1035.2）mL，HCC患者的中位生存期为631天，1年，3年和5年总生存率分别为73.2％ 28.8％和19.6％。肝硬化，多发结节，肿瘤血栓形成和高AFP水平是影响术后生存的危险因素。
关键词：

中国;肝切除;肝细胞癌

结论：
29417360
DOI：
10.1007 / s11427-017-9259-9