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GeoVax and CaroGen to Collaborate On Development of Therapeutic Hepatitis B Vaccine
February 07, 2018 09:00 ET | Source: GeoVax, Inc.
Targeting Chronic Hepatitis B Infections Affecting More Than 240 Million People Worldwide
ATLANTA, GA, Feb. 07, 2018 (GLOBE NEWSWIRE) -- GeoVax Labs, Inc. (OTCQB: GOVX), a biotechnology company developing human vaccines, announced today that it is collaborating with CaroGen Corporation on the development of a combination immunotherapy treatment for chronic hepatitis B virus (HBV) infection.
The project will include testing GeoVax’s MVA-VLP-HBV (Modified Vaccinia Ankara-Virus Like Particle-Hepatitis B Virus) vaccine candidate in combination with CaroGen’s HBV virus-like vesicles (VLVs) vaccine candidate in prophylactic and therapeutic animal models of HBV. Therapeutic experiments may be carried out in combination with anti-viral drugs, TLR agonists, or immune checkpoint inhibitors which are currently in use (or anticipated to be used in future) as part of the standard of care for treatment of this particularly difficult to treat disease. GeoVax’s vaccine candidate is based upon its novel MVA-VLP vector platform, which has been proven safe in multiple human clinical trials of the company’s HIV vaccine. CaroGen’s vaccine candidate employs a transformative VLV platform technology developed at Yale University School of Medicine and exclusively licensed by CaroGen for the development and commercialization of immunotherapies worldwide.
Farshad Guirakhoo, Ph.D., GeoVax’s Chief Scientific Officer, stated, “There is a clear medical need to treat chronic HBV infections, which affect hundreds of millions of people around the world, many of whom die due to complications of HBV including cirrhosis and cancer. Multiple preventive vaccines exist to protect against acquiring HBV infection, but they cannot help patients already diagnosed with the disease. Although HBV infection can be treated with drugs, the treatments cure just 5% of patients and only suppress the replication of the virus in others. Therefore, most people who start treatments must continue with them for life. Moreover, diagnosis and treatment options are very limited in resource/low income-constrained populations, which leads to many patients succumbing to the disease within months of diagnosis.”
Dr. Guirakhoo continued, “We are pleased to begin this collaboration with CaroGen, as it complements our existing collaboration with Georgia State University, increasing our chances of success. Our strategy is to use both vaccines as part of a combination strategy with current or future HBV treatments to induce functional antibodies as well as CD4+, CD8+ T cell responses to break tolerance to HBV antigens and clear the infection. Our ultimate goal is to significantly increase the current cure rate of chronic HBV infection while reducing the duration of drug therapy, overall treatment costs, side effects, and potential drug resistance.”
Valerian Nakaar, Ph.D., Vice President, Research & Development at CaroGen, commented, “There is a compelling mechanistic rationale for combining both platform technologies for the treatment of HBV. We are excited to initiate this collaboration because the success accruing from these studies will portend well for other hard-to-treat chronic infections.”
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发表于 2018-2-8 04:26
